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BJOERN MENGER MD PETER M. VOGT MD Prof.Dr.med ILSE D. JACOBSEN PhD Dr.med.vet CHRISTINA ALLMELING JOERN W. KUHBIER cand. med. FRANK MUTSCHMANN Dr.med.vet KERSTIN REIMERS PhD Dr.rer.nat 《Veterinary surgery : VS》2010,39(2):232-233
Objective— This case report describes the surgical removal of an intra‐abdominal tumor from a Mexican axolotl (Ambystoma mexicanum). The animal was admitted with left abdominal swelling that had increased over 4 months. Methods— Surgical removal was performed under general anesthesia with MS222 under an operating microscope. Exploratory laparotomy was performed through 2.5 dorsocranial skin incision in the left flank, followed by subcutaneous dissection. Results— The tumor involved the spleen, was adjacent to the descending colon, and supplied by vessels from the spleen, stomach, and colon. The mass was removed by clamping and transecting the spleen and the peritoneum was closed with a continuous suture pattern, while abdominal muscles and skin were closed in layers. After a total duration time of anesthesia of 90 minutes the animal was kept in prophylactic antibiotic baths. Tissue sections revealed characteristics of both lymphangiosarcoma and lymphosarcoma with an appearance typical for a malignant tumor. Conclusions— Abdominal surgery was performed in an axolotl and the surgical wound healed without complication. 相似文献
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AMY K. LEBLANC BJOERN JAKOBY DAVID W. TOWNSEND GREGORY B. DANIEL 《Veterinary radiology & ultrasound》2008,49(2):182-188
Positron emission tomography (PET) has found widespread application for staging and monitoring neoplastic diseases in humans. PET is becoming more available in veterinary medicine, therefore biodistribution of 2-deoxy-2-[18 F]fluoro- d -glucose (18 FDG) in normal dogs is needed for lesion interpretation in disease states. A large field-of-view (FOV) PET scanner with a 70 cm bore diameter and a 53-cm FOV was used in this study to acquire dynamic 18 FDG uptake data from parenchymal organs in seven normal dogs. A 2-h, dynamic list-mode acquisition was initiated simultaneously with intravenous 18 FDG injection. Regions of interest (ROIs) were manually drawn over liver, spleen, left and right renal cortices, left ventricular free wall, and thymus. Standardized uptake values (SUVs) of these organs were calculated for 24 5-min frames over the 2-h acquisition. This SUV data from parenchymal organs of normal dogs compares favorably with those of normal humans and will be used in ongoing canine studies using PET to evaluate various diseases. 相似文献
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AMY K. LEBLANC BJOERN W. JAKOBY DAVID W. TOWNSEND GREGORY B. DANIEL 《Veterinary radiology & ultrasound》2009,50(2):215-223
Positron Emission Tomography (PET) using the glucose analog 2-deoxy-2-[18 F]fluoro- d -glucose (18 FDG) is a common imaging modality for diagnosis and management of many human malignancies. We evaluated 18 FDG-PET in dogs with either multicentric lymphoma (LSA) or cutaneous mast cell tumor (MCT). A prototype large field-of-view PET scanner was used to collect whole-body images in nine dogs with LSA or MCT. Both tumors were characterized by avidity for 18 FDG. In dogs with LSA, 18 FDG-PET correctly identified involvement of superficial and internal lymph nodes, liver, and spleen. Repeated PET scans after induction chemotherapy demonstrated resolution of abnormal 18 FDG uptake within these sites. In dogs with MCT, 18 FDG-PET correctly identified MCT metastasis to regional lymph nodes in all dogs in which this was suspected or confirmed with cytology or biopsy before the PET scan. In two dogs, additional sites of mast cell disease were identified with 18 FDG-PET that were undetected on physical examination and/or regional lymph node cytology. 18 FDG-PET holds promise as a whole-body staging method for canine LSA and MCT. 相似文献
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AMY K. LEBLANC JON S. WALL FEDERICA MORANDI STEPHEN J. KENNEl ALAN STUCKEY BJOERN JAKOBY DAVID W. TOWNSEND GREGORY B. DANIEL 《Veterinary radiology & ultrasound》2009,50(4):436-441
Positron emission tomography (PET) with 2-deoxy-2-[18 F]fluoro- d -glucose (18 FDG) is an important imaging modality for diagnosis and staging of human neoplastic disease. The purpose of this study is to describe the normal 18 FDG uptake in adult cats. Six adult healthy female cats were used. Cats were sedated and then injected intravenously with 74.0±13.0 (mean±SD) MBq of 18 FDG. General anesthesia was induced and cats were placed in ventral recumbancy on the PET scanner's bed. Static images using multiple bed positions were acquired approximately 60–90 min after injection. A transmission scan was acquired at each bed position utilizing a 57 Co point source to perform attenuation and scatter correction. Regions of interest (ROIs) were drawn over the liver, right and left renal cortices, left ventricular wall, and wall of ascending and descending colonic segments. Standardized uptake values (SUV) were calculated using an established formula. Kidneys and intestinal tract had relatively intense uptake of 18 FDG; liver activity was intermediate; the spleen was not identified in any of the cats. Cardiac activity was variable but intense activity was noted in the left ventricular myocardium in most cats. No appreciable lung uptake was noted. Mean±SD SUV values were calculated. This study established the normal pattern of uptake of 18 FDG in adult cats and provided baseline data for comparison with future studies evaluating a variety of neoplastic and nonneoplastic diseases. 相似文献
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