The failure of selenium supplementation to prevent copper-induced liver damage in Fischer 344 rats.     

E M Aburto  A Cribb  I C Fuentealba  B O Ikede  F S Kibenge    F Markham 《Canadian journal of veterinary research》2001,65(2):104-110

This study evaluates the ability of selenium (Se) supplementation to prevent experimental copper (Cu)-induced hepatocellular damage. Weanling male Fischer 344 rats were randomly assigned to groups of 15, 3 groups (A,B,C) were fed Cu-loaded diets (containing 2000 microg/g copper, added as CuSO4) and different levels of Se (added as Na2SeO3 x 5H2O) as follows: A) Cu-loaded/Se adequate diet (0.4 microg/g Se, fed basis); B) Cu-loaded/Se-supplemented diet (2 microg/g Se); and C) Cu-loaded/Se-deficient diet (< 0.2 microg/g). Three additional groups (D,E,F) were fed diets containing adequate levels of Cu (14 microg/g Cu, fed basis) and different levels of Se as follows: D) Cu-adequate/Se-adequate diet; E) Cu-adequate/Se-supplemented diet (2 microg/g Se); and F) Cu-adequate/Se-deficient (< 0.2 microg/g) diet. After 4, 8, and 12 weeks on the experimental diets, liver samples were processed for histology, histochemistry, metal analysis, glutathione peroxidase (GSH-Px) measurement, and quantification of malondialdehyde (MDA). Morphologic changes characteristic of Cu-associated hepatitis, without an increase in hepatic MDA levels, were seen in all Cu-loaded rats in each sampling. Similar changes occurred in rats fed Se-adequate, Se-supplemented and Se-deficient diets. This study demonstrates that Fischer 344 rats fed 2000 microg/g Cu develop morphologic changes due to Cu toxicity without evidence of lipid peroxidation. Furthermore, Se supplementation does not result in protection against Cu-induced liver injury.  相似文献   

Platynosomum concinnum infection in cats in Nigeria     

B O Ikede  G J Losos  T T Isoun 《The Veterinary record》1971,89(24):635-638

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Pathological changes in cattle infected with Trypanosoma brucei   总被引：1，自引：0，他引：1  

B O Ikede  G J Losos 《Veterinary pathology》1972,9(4):272-277

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Mitotic instability in Aspergillus nidulans caused by the fungicides iprodione,procymidone and vinclozolin     

Spyros G. Georgopoulos  Michael Sarris  Basil N. Ziogas 《Pest management science》1979,10(5):389-392

The fungicides iprodione, procymidone and vinclozolin were found to increase greatly the frequency of mitotic recombination in diploid colonies of Aspergillus niduluns. Although generally more potent, these fungicides do not appear to differ in their activity from members of a previously suggested ?aromatic hydrocarbon group’? with which they should be classified in this context.  相似文献   

Bovine Lymphosarcoma: The Effect of Inoculations on Newborn Calves     

Basil C. Hatziolos 《Zoonoses and public health》1968,15(5):564-580

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Many Australian veterinarians have recently temporarily departed Australia for the United Kingdom     

Brock B  Mahar F  Wilson S 《Australian veterinary journal》2003,81(1-2):23-24

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CAVM commentary draws negative reactions     

Tangredi BP 《Journal of the American Veterinary Medical Association》2003,223(4):434; author reply 434, 436

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A non-Mendelian inheritance of resistance to strobilurin fungicides in Ustilago maydis     

Ziogas BN  Markoglou AN  Tzima A 《Pest management science》2002,58(9):908-916

Mutants of Ustilago maydis (DC) Corda with high resistance to azoxystrobin (RF 164 to 4714, based on EC50 values), an inhibitor of mitochondrial electron transport at the cytochrome bc1 complex, were isolated in a mutation frequency of 2.3 x 10(-7) after nitrosoguanidine mutagenesis and selection on media containing 1 microgram ml-1 azoxystrobin in addition to 0.5 mM salicylhydroxamate (SHAM), a specific inhibitor of cyanide-resistant (alternative) respiration. Oxygen uptake in whole cells was strongly inhibited in the wild-type strains by azoxystrobin (1.5 micrograms ml-1) in addition to SHAM (1 mM), but not in the mutant isolates. Genetic analysis with nine such mutant isolates resulted in progeny phenotypes which did not follow Mendelian segregation, but satisfied the criteria of non-Mendelian (cytoplasmic) heredity. In crosses between three mutant isolates with the compatible wild-type strains, the sensitivity was inherited by progeny maternally from the wild-type parent strain (criterion of uniparental inheritance). In crosses between wild-type strains and remaining mutant isolates, a continuous distribution of sensitivity in the progeny was found (criterion of vegetative segregation). The third criterion of cytoplasmic resistance (criterion of intracellular selection) was fulfilled by experiments on the stability of resistance phenotypes. With two exceptions, a reduction of resistance was observed in the mutant strains when they were grown on inhibitor-free medium. Recovery of the high resistance level was observed after they were returned to the selection medium. Cross-resistance studies with other fungicides, which also inhibit electron transport through complex III of respiratory chain, showed that mutations for resistance to azoxystrobin were also responsible for reduced sensitivity to kresoxim-methyl (RF 18 to 1199) and to antimycin-A (RF 20 to 305), which act at the Qo and Qi sites of the cytochrome bc1 complex, respectively. Studies of the fitness of azoxystrobin-resistant isolates showed that these mutations appeared to be pleiotropic, having significant adverse effects on growth in liquid culture and pathogenicity on young corn plants.  相似文献   

Some factors affecting the storage of fresh breadfruit     

John Marriott  Cynthia Perkins  Basil O. Been 《Scientia Horticulturae》1979,10(2):177-181

Breadfruit (Artocarpus altilis (Park) Fosberg) is a highly perishable tropical fruit which can be packed in sealed polyethylene bags and stored under refrigeration. The storage period between harvesting and softening was greater for fruit harvested partially mature than fully mature and for fruit which were harvested by picking or catching rather than traditional procedures. In 4 storage trials and a single shipping trial, the majority of partially mature fruits harvested by picking were still firm after 15 days although a significant proportion had commenced softening.  相似文献   

Congenital dyserythropoiesis and dyskeratosis in a polled Hereford calf.          下载免费PDF全文

S A Burton  B O Ikede  J Lofstedt  G P Keefe    L M Miller 《The Canadian veterinary journal. La revue veterinaire canadienne》1994,35(8):519-520

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