Borax toxicity     

Brockman RP  Audette RJ  Gray M 《The Canadian veterinary journal. La revue veterinaire canadienne》1985,26(4):147

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Intrahepatic congenital portosystemic shunts in dogs: short‐ and long‐term outcome of suture attenuation          下载免费PDF全文

M. S. Tivers  V. J. Lipscomb  P. Bristow  D. J. Brockman 《The Journal of small animal practice》2018,59(4):201-210

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Double chambered right ventricle in 9 cats     

Koffas H  Fuentes VL  Boswood A  Connolly DJ  Brockman DJ  Bonagura JD  Meurs KM  Koplitz S  Baumwart R 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(1):76-80

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Survival times of and prognostic indicators for dogs with heart base masses: 25 cases (1986-1999)     

Vicari ED  Brown DC  Holt DE  Brockman DJ 《Journal of the American Veterinary Medical Association》2001,219(4):485-487

OBJECTIVE: To determine survival times of and prognostic indicators for dogs with heart base masses. DESIGN: Retrospective study. ANIMALS: 25 dogs. PROCEDURE: Medical records were reviewed to obtain information regarding signalment; initial complaint; results of physical examination, radiography, electrocardiography, and echocardiography; surgical findings; medical and surgical treatment; outcome; necropsy findings; survival time; and cause of death. RESULTS: Survival time ranged from 0 to 1,096 days (mean, 213 days; median, 57 days). None of the variables examined, including initial complaints and results of physical examination, radiography, electrocardiography, and echocardiography, were associated with survival time. However, dogs that underwent pericardectomy had a significantly longer mean survival time (mean +/- SD, 661 +/- 170 days) than did dogs that were treated medically (129 +/- 51 days). CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that dogs with heart base masses that undergo pericardectomy may survive longer than those that receive medical treatment alone.  相似文献   

Depression of hyperglycemic response to glucagon by parenteral lead administration in sheep.          下载免费PDF全文

R P Brockman 《Canadian journal of veterinary research》1978,42(1):43-45

The insulin and glucose responses to glucagon infusions (27 microgram/hr) were determined in sheep before and after parenteral lead treatment (6 mg/kg intravenously). Glucose production was measured by primed continuous infusion of [6-3H]glucose. Glucagon and insulin concentrations before and during glucagon infusions were not significantly different between lead treatment and control experiments. Lead administration did not affect the concentration or production of glucose in the preinfusion period. However, depressed hyperglycemia during glucagon infusion in lead treated experiments tended to be associated with decreased glucose production. The reduced glucogenic response to glucagon may be the result of reduced function of pyruvate carboxylase, a key hepatic gluconeogenic enzyme in sheep, from lead induced impairment of mitochondrial function.  相似文献   

Effects of glucagon and insulin on lipolysis and ketogenesis in sheep.          下载免费PDF全文

R P Brockman 《Canadian journal of veterinary research》1976,40(2):166-170

The hepatic and portal productions of acetoacetate and beta-hydroxybutyrate and lipolysis were studied in normal and insulin-controlled alloxan-diabetic sheep. Since hyperinsulinemia is associated with glucagon administration, the latter group of sheep were used to maintain constant plasma insulin levels. After control values were obtained glucagon was infused intraportally at 90 mug/hr for two hours. The ketone body production by portal drained viscera was not significantly affected by glucagon. In alloxanized sheep, glucagon significantly (P less than 0.01) increased net hepatic production of acetoacetate (from -0.54 +/- 0.08 to 0.46 +/- 0.07 g/hr). Lipolysis also increased. However, in the normal sheep, hyperinsulinemia prevented any stimulatory effect of glucagon on hepatic ketogenesis and lipolysis. Therefore, while glucagon appears capable of stimulating ketogenesis andlipolysis, these effects are readily suppressed by insulin.  相似文献   

Concentration of copper in livers of Saskatchewan cattle at slaughter.   总被引：2，自引：1，他引：1       下载免费PDF全文

R P Brockman 《The Canadian veterinary journal. La revue veterinaire canadienne》1977,18(6):168-170

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Surgical and nonsurgical management of and selected risk factors for spontaneous pneumothorax in dogs: 64 cases (1986-1999)     

Puerto DA  Brockman DJ  Lindquist C  Drobatz K 《Journal of the American Veterinary Medical Association》2002,220(11):1670-1674

OBJECTIVE: To compare results of surgical versus nonsurgical treatment of spontaneous pneumothorax in dogs. DESIGN: Retrospective study. ANIMALS: 64 dogs with pneumothorax without any history of antecedent trauma. PROCEDURE: Information on signalment, thoracic radiographic findings, treatment, histologic findings, and outcome was obtained from the medical records. Signalment of affected dogs was compared with signalment of a control population of 260 dogs examined by the emergency service for reasons other than pneumothorax during the study period. RESULTS: Siberian Huskies were overrepresented in the case population, compared with the control population of dogs examined by the emergency service for other reasons. Twenty-eight dogs were treated without surgery (ie, thoracocentesis or tube thoracostomy with or without cage rest), and 36 were treated with surgery. Information regarding final outcome was available for 33 dogs treated with surgery (median follow-up time, 485 days) and 15 dogs treated without surgery (median follow-up time, 366 days). Dogs that underwent surgery had significantly lower recurrence (1/30) and mortality (4/33) rates, compared with dogs treated without surgery (6/12 and 8/15, respectively). A definitive diagnosis was obtained for 38 dogs, including 34 of 36 dogs undergoing surgery; 26 had bullous emphysema and 4 had neoplasia. Two dogs developed spontaneous pneumothorax secondary to migration of plant foreign bodies. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that recurrence and mortality rates for dogs with spontaneous pneumothorax managed surgically were significantly lower than rates for dogs managed by nonsurgical means alone. Early surgical intervention is recommended for definitive diagnosis and treatment of dogs with spontaneous pneumothorax.  相似文献   

Complications and long-term outcomes of the ligation of congenital portosystemic shunts in 49 cats     

Lipscomb VJ  Jones HJ  Brockman DJ 《The Veterinary record》2007,160(14):465-470

Only two of 49 cats undergoing surgical ligation of congenital extra- and intrahepatic portosystemic shunts died perioperatively, a mortality rate comparable with the mortality rates of dogs undergoing surgical attenuation of congenital portosystemic shunts and cats in which the shunts are attenuated with an ameroid ring constrictor. Thirty (83 per cent) of the 36 cats for which long-term information was available were still alive at a median follow-up period of 47 months (range six to 105 months); the outcome was excellent (no clinical signs) in 20 of them (median follow-up 37 months, range six to 105 months) and good (minimal clinical signs) in seven (median follow-up 39 months, range 10 to 73 months) and none of these 27 cats was on any long-term medication or special diet. The only major cause of morbidity was the development of neurological signs in 18 (37 per cent) of the cats. These included seizures and a wide variety of other neurological signs, and their development and persistence was not affected by the presence of preoperative seizures, the type of shunt, the degree of shunt attenuation or the age of the cat. The serum concentrations of ammonia and preprandial bile acids were normal or significantly below normal in the cats with neurological signs. Liver histopathology was similar in the cats with and without neurological signs. Ten (56 per cent) of the 18 cats that developed neurological signs recovered normal neurological function long term.  相似文献   

"Coulomb Staircase" at Room Temperature in a Self-Assembled Molecular Nanostructure     

RP Andres  T Bein  M Dorogi  S Feng  JI Henderson  CP Kubiak  W Mahoney  RG Osifchin  R Reifenberger 《Science (New York, N.Y.)》1996,272(5266):1323-1325

Double-ended aryl dithiols [alpha,alpha'-xylyldithiol (XYL) and 4,4'-biphenyldithiol] formed self-assembled monolayers (SAMs) on gold(111) substrates and were used to tether nanometer-sized gold clusters deposited from a cluster beam. An ultrahigh-vacuum scanning tunneling microscope was used to image these nanostructures and to measure their current-voltage characteristics as a function of the separation between the probe tip and the metal cluster. At room temperature, when the tip was positioned over a cluster bonded to the XYL SAM, the current-voltage data showed "Coulomb staircase" behavior. These data are in good agreement with semiclassical predictions for correlated single-electron tunneling and permit estimation of the electrical resistance of a single XYL molecule (approximately18 ± 12 megohms).  相似文献