Clinical equine dysautonomia and autonomic neuron damage.     

D L Doxey  D M Pogson  E M Milne  J S Gilmour  H K Chisholm 《Research in veterinary science》1992,53(1):106-109

Damage to the neurons of selected autonomic ganglia was quantified in relation to the severity of the clinical signs shown in acute, subacute and chronic cases of dysautonomia (grass sickness). No connection between the clinical severity of acute or subacute dysautonomia and the amount of neuronal damage in the superior cervical, stellate and coeliaco-mesenteric ganglia could be demonstrated. However, a higher proportion of normal neurons were found in chronic cases. Jejunal submucosal neuronal damage was correlated with clinical severity but further work is required to confirm this finding and to establish how widespread the alimentary neuronal lesions are in dysautonomia of different severities.  相似文献   

Small intestine and small colon neuropathy in equine dysautonomia (grass sickness)     

D. L. Doxey  E. M. Milne  M. P. Woodman  J. S. Gilmour  H. K. Chisholm 《Veterinary research communications》1995,19(6):529-543

The number of neurons in the coeliacomesenteric ganglia and the myenteric and submucosal plexuses of the jejunum, ileum and small colon, and the pathological changes induced in them, were studied in various types of equine dysautonomia. In all forms of dysautonomia, severe and extensive neuron loss and damage occurred in the ileum. In acute and subacute dysautonomia, jejunal neuron loss and damage were severe, but in chronic cases significantly less loss or damage occurred. The damage followed the same pattern in the small colon but it was always less obvious than in the jejunum. The distribution of the damage was uniform within a segment of the intestine. In fatal cases of dysautonomia, the clinical severity and duration of illness seems, in most instances, to be related to the amount of neuronal disruption occurring in the jejunum. Severe disruption results in acute/subacute dysautonomia, while milder damage leads to the chronic form.No case of dysautonomia was encountered in which enteric neuron loss and damage occurred without significant neuronal disruption also occurring in the coeliacomesenteric ganglia.Ileal neuronal damage and loss are not invariably worse than that in the jejunum, and the possible reasons for this, together with the relationship between neuronal damage and possible causes of dysautonomia, are discussed.Abbreviations H&E haematoxylin and eosin Deceased. Formerly of the Moredun Research Institute, 408 Gilmerton Road, Edinburgh, EH17 7JH, UK  相似文献   

Feline eosinophilic keratitis          下载免费PDF全文

Chisholm WH 《The Canadian veterinary journal. La revue veterinaire canadienne》1989,30(5):438

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Massive mammary enlargement in a cat   总被引：1，自引：1，他引：0       下载免费PDF全文

Chisholm H 《The Canadian veterinary journal. La revue veterinaire canadienne》1993,34(5):315

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兽药使用环节存在的问题及对策     

陈奕春  陈银伟  占伟慧  应振火 《中国兽药杂志》2005,39(10):47-47

经过对兽药生产厂家和经营企业几年的整治,尤其是新<兽药管理条例>和<兽药标签和说明书管理办法>出台后,又经过GMP认证,兽药生产经营市场秩序和经营行为得到了一定的规范.但兽药使用环节中却存在诸多的问题,如:违法使用人用药品;违法使用禁用兽药;不执行休药期规定;未建立台帐等等.这些问题的存在,直接导致了动物产品的安全性问题.对此,笔者分析了兽药使用环节存在问题的原因,并对解决这些问题提出了个人观点.  相似文献   

Dendromonocotyle colorni sp. n. (Monogenea: Monocotylidae) from the skin of Himantura uarnak (Dasyatididae) from Israel and a new host record for D. octodiscus from the Bahamas     

Chisholm LA  Whittington ID  Kearn GC 《Folia parasitologica》2001,48(1):15-20

Dendromonocotyle colorni sp. n. (Monogenea: Monocotylidae) is described from the dorsal skin surface of two specimens of Himantura uarnak (Forssk?l) kept at the Eilat Underwater Observatory in Israel. Dendromonocotyle colorni is distinguished from the other eight species in the genus by the morphology of the terminal papillar sclerite on the haptor, the distal portion of the male copulatory organ and the morphology of the vagina. The development of the male copulatory organ is detailed for D. colorni and the adaptations of species of Dendromonocotyle to life on the dorsal skin surface of rays are discussed. Dendromonocotyle octodiscus Hargis, 1955 was identified from the dorsal skin surface of the southern stingray Dasyatis americana Hildebrand et Schroeder off Bimini, Bahamas and represents a new host record.  相似文献   

正交试验法优化普抗合剂制备工艺     

张媛  杜洪建  盛柳青  包卫华 《中国兽药杂志》2007,41(12):36-37

以干浸膏得率和黄芩苷提取率为考核指标,采用正交试验法对普抗合剂水提取醇沉淀制备工艺进行考察.普抗合剂最佳制备工艺方案为加水量10倍,提取2次,每次1 h,55%的乙醇沉淀杂质 .该工艺科学合理,适合于大规模工业生产.  相似文献   

High-performance solid Acid fuel cells through humidity stabilization     

Boysen DA  Uda T  Chisholm CR  Haile SM 《Science (New York, N.Y.)》2004,303(5654):68-70

Although they hold the promise of clean energy, state-of-the-art fuel cells based on polymer electrolyte membrane fuel cells are inoperable above 100 degrees C, require cumbersome humidification systems, and suffer from fuel permeation. These difficulties all arise from the hydrated nature of the electrolyte. In contrast, "solid acids" exhibit anhydrous proton transport and high-temperature stability. We demonstrate continuous, stable power generation for both H2/O2 and direct methanol fuel cells operated at approximately 250 degrees C using a humidity-stabilized solid acid CsH2PO4 electrolyte.  相似文献   

Long base line interferometry: a new technique   总被引：1，自引：0，他引：1  

Broten NW  Legg TH  Locke JL  McLeish CW  Richards RS  Chisholm RM  Gush HP  Yen JL  Galt JA 《Science (New York, N.Y.)》1967,156(3782):1592-1593

The technique of using magnetic-tape recorders and atomic frequency standards to operate two widely separated radio telescopes as a phase-coherent interferometer when the stations have no radio-frequency connecting link has been successfully tested at the National Research Council of Canada's Algonquin Radio Observatory.  相似文献   

Ecosystem experiments   总被引：1，自引：0，他引：1  

Carpenter SR  Chisholm SW  Krebs CJ  Schindler DW  Wright RF 《Science (New York, N.Y.)》1995,269(5222):324-327

Experimental manipulations of entire ecosystems have been conducted in lakes, catchments, streams, and open terrestrial and marine environments. Experiments have addressed applied problems of ecosystem management and complex responses of communities and ecosystems to perturbations. In the course of some experiments, environmental indicators and models have been developed and tested. Surprising results with implications for ecological understanding and management are common.  相似文献