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Michael Muleme Robert Barigye Margaret L. Khaitsa Eugene Berry Anthony W. Wamono Chrisostom Ayebazibwe 《Tropical animal health and production》2012,45(1):35-43
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. In Uganda, FMD outbreaks are mainly controlled by ring vaccination and restriction of animal movements. Vaccination stimulates immunity and prevents animals from developing clinical signs which include lameness, inappetence, and decreased production. Ring vaccination and restriction of animal movements have, however, not successfully controlled FMD in Uganda and outbreaks reoccur annually. The objective of this study was to review the use of FMD virus (FMDV) vaccines and assess the effectiveness of vaccination programs for controlling FMD in Uganda (2001–2010), using retrospective data. FMD vaccine distribution patterns in Uganda (2001–2010) matched occurrence of outbreaks with districts reporting the highest number of outbreaks also receiving the largest quantity of vaccines. This was possibly due to “fire brigade” response of vaccinating animals after outbreaks have been reported. On average, only 10.3 % of cattle within districts that reported outbreaks during the study period were vaccinated. The average minimum time between onset of outbreaks and vaccination was 7.5 weeks, while the annual cost of FMDV vaccines used ranged from US $58,000 to 1,088,820. Between 2001 and 2010, serotyping of FMD virus was done in only 9/121 FMD outbreaks, and there is no evidence that vaccine matching or vaccine potency tests have been done in Uganda. The probability of FMDV vaccine and outbreak mismatch, the delayed response to outbreaks through vaccination, and the high costs associated with importation of FMDV vaccines could be reduced if virus serotyping and subtyping as well as vaccine matching were regularly done, and the results were considered for vaccine manufacture. 相似文献
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Pam Dachung Luka Chrisostom Ayebazibwe David Shamaki Frank Norbert Mwiine Joseph Erume 《Journal of veterinary science (Suw?n-si, Korea)》2012,13(3):323-325
Peste des petits ruminants (PPR) diagnosis from suspected samples from sheep and goats was carried out. Buffy coat, tissues, and oculo-nasal swabs were analyzed using nucleoprotein (NP3/NP4) and fusion protein (F1/F2) gene primers, respectively. Analysis of the sample types and primer set revealed that buffy coat are the best type of samples for PPR diagnosis and the use of two set of primers will increase the number of positives. 相似文献
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Patterns,risk factors and characteristics of reported and perceived foot-and-mouth disease (FMD) in Uganda 总被引：1，自引：1，他引：0
Ayebazibwe Chrisostom Tjørnehøj Kirsten Mwiine Frank N. Muwanika Vincent B. Ademun Okurut Anna Rose Siegismund Hans R. Alexandersen Soren 《Tropical animal health and production》2010,42(7):1547-1559
Patterns of outbreaks of foot-and-mouth disease (FMD) in Uganda were elucidated from spatial and temporal retrospective data
retrieved from monthly reports from District Veterinary Officers (DVOs) to the central administration for the years spanning
2001–2008. An assessment of perceived FMD occurrence, risk factors and the associated characteristics was made based on semi-structured
questionnaires administered to the DVOs. During this period, a total of 311 FMD outbreaks were reported in 56 (70%) out of
Uganda’s 80 districts. The number of reported FMD outbreaks changed over time and by geographical regions. Occurrence of FMD
was significantly associated with the dry season months (p = 0.0346), the time when animals movements are more frequent. The average number of FMD outbreaks was higher for some sub-counties
adjacent to national parks than for other sub-counties, whilst proximity to international border only seemed to play a role
at the southern border. DVOs believed that the major risk factor for FMD outbreaks was animal movements (odds ratio OR 50.8,
confidence interval CI 17.8–144.6) and that most outbreaks were caused by introduction of sick animals. 相似文献
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