Laryngeal mask airway and transient hypercapnic hyperpnea for video‐endoscopic assessment of unilateral laryngeal paralysis in dogs          下载免费PDF全文

Daniel M. Sakai MV  DACVAA  Manuel Martin‐Flores MV  DACVAA  Amanda K. Jones PhD  Galina M. Hayes BVSc  PhD  DACVECC  DACVS‐SA  Marina J. McConkey DVM  DACVS‐SA  Jonathan Cheetham VetMB  PhD  DACVS‐LA 《Veterinary surgery : VS》2018,47(4):543-548

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Reduction and recovery of N-acetylglucosamine-1-phosphate transferase activity in the liver of sheep and rats after a single subcutaneous dose of tunicamycin     

PL STEWART  C MAY CSIRO  MV JAGO 《Australian veterinary journal》1998,76(4):287-288

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Correlation Between Liver Volume,Portal Vascular Anatomy,and Hepatic Perfusion in Dogs With Congenital Portosystemic Shunt Before and After Placement of Ameroid Constrictors     

Leticia Daniel MV  Michele A. Steffey DVM  Diplomate ACVS  Philipp D. Mayhew BVM&S  Diplomate ACVS  Kelli N. Mayhew VMD  Diplomate ACVS  William T. N. Culp VMD  Diplomate ACVS  Geraldine B. Hunt BVSc  PhD  FACVSc 《Veterinary surgery : VS》2014,43(8):926-934

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A common mechanism of chromosomal translocation in T- and B-cell neoplasia   总被引：29，自引：0，他引：29  

L R Finger  R C Harvey  R C Moore  L C Showe  C M Croce 《Science (New York, N.Y.)》1986,234(4779):982-985

The chromosomal breakpoint involved in the t(8;14)(q24;q11) chromosome translocation in the SKW-3 cell line, which directly involves the 3' flanking region of the c-myc gene, was cloned and sequenced. The breakpoint on chromosome 8 mapped to a position 3 kb 3' of c-myc while the chromosome 14 breakpoint occurred 36 kb 5' of the gene for the constant region of the alpha chain of the T-cell receptor (TCR). The translocation resulted in a precise rearrangement of sequences on chromosome 8 and what appears to be a functional J alpha segment on chromosome 14. Signal sequences for V-J joining occurred at the breakpoint positions on both chromosomes 14 and 8, suggesting that the translocation occurs during TCR gene rearrangement and that it is catalyzed by the enzymatic systems involved in V-J joining reactions. The involvement of c-myc in the translocation and the association of joining signals at the breakpoints provides a parallel to the situation observed in the translocations involving c-myc and the immunoglobulin loci in B-cell neoplasms and suggests that common mechanisms of translocation and oncogene deregulation are involved in B- and T-cell malignancies.  相似文献   

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining   总被引：97，自引：0，他引：97  

Y Tsujimoto  J Gorham  J Cossman  E Jaffe  C M Croce 《Science (New York, N.Y.)》1985,229(4720):1390-1393

In this study, the joining sequences between chromosomes 14 and 18 on the 14q+ chromosomes of a patient with pre-B-cell leukemia and four patients with follicular lymphoma carrying a t(14;18) chromosome translocation were analyzed. In each case, the involved segment of chromosome 18 has recombined with the immunoglobulin heavy-chain joining segment (JH) on chromosome 14. The sites of the recombination on chromosome 14 are located close to the 5' end of the involved JH segment, where the diversity (D) regions are rearranged with the JH segments in the production of active heavy-chain genes. As extraneous nucleotides (N regions) were observed at joining sites and specific signal-like sequences were detected on chromosome 18 in close proximity to the breakpoints, it is concluded that the t(14;18) chromosome translocation is the result of a mistake during the process of VDJ joining at the pre-B-cell stage of differentiation. The putative recombinase joins separated DNA segments on two different chromosomes instead of joining separated segments on the same chromosome, causing a t(14;18) chromosome translocation in the involved B cells.  相似文献   

Repression of rearranged mu gene and translocated c-myc in mouse 3T3 cells X Burkitt lymphoma cell hybrids   总被引：18，自引：0，他引：18  

K Nishikura  A ar-Rushdi  J Erikson  E DeJesus  D Dugan  C M Croce 《Science (New York, N.Y.)》1984,224(4647):399-402

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Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene   总被引：34，自引：0，他引：34  

R Dalla-Favera  R C Gallo  A Giallongo  C M Croce 《Science (New York, N.Y.)》1982,218(4573):686-688

Nonrandom chromosome rearrangements of chromosome 22 have been identified in different human malignancies. As a result of Southern blot hybridization of a c-sis probe to DNA's from mouse-human somatic cell hybrids, the human homolog (c-sis) of the transforming gene of simian sarcoma virus was assigned to chromosome 22. Hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the region q11-qter of chromosome 22 to chromosome 17 were also analyzed. These studies demonstrate that the human c-sis gene is on region 22q11 greater than qter.  相似文献   

Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells   总被引：15，自引：0，他引：15  

M Isobe  J Erikson  B S Emanuel  P C Nowell  C M Croce 《Science (New York, N.Y.)》1985,228(4699):580-582

The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage.  相似文献   

Oestrogen,Progesterone and Oxytocin Receptors and COX‐2 Expression in Endometrial Biopsy Samples from the Induction of Ovulation to Luteolysis in Llamas (Lama glama)     

CP Bianchi  A Meikle  MA Alvarez  MA Benavente  MV Cavilla  E Rodríguez  MA Aba 《Reproduction in domestic animals》2013,48(4):681-690

Endometrial expression of oestrogen (ERα), progesterone (PR) and oxytocin receptor (OR) and cyclooxygenase‐2 (COX‐2) was evaluated from the induction of ovulation to luteolysis in llamas. Ovarian activity was daily assessed by ultrasonography in five females. Ovulation was induced immediately after the detection of an ovulatory follicle by a GnRH injection (Day 0). Endometrial samples were obtained by transcervical biopsies from the left and right horns on day 0 and days 4, 8, 10 and 12 post‐GnRH. Blood samples were collected daily for progesterone and estradiol‐17β determinations by RIA. An immunohistochemical technique was used to study receptors population and COX‐2 expression which were then evaluated by two independent observers. The expression of ERα and PR was highest on day 0 in the luminal epithelium and stroma in association with high plasma estradiol‐17β concentrations. Thereafter, a decrease in ERα population was registered on day 4 and a new increase of its expression was observed between days 8 and 12 in those cell types. Conversely, PR population was gradually down‐regulated until its lowest expression was reached on day 10 post‐GnRH in the luminal epithelium. Content of OR was similar throughout the study in all cell types. The expression of COX‐2 was highest from day 8 to 12 post‐GnRH in the luminal epithelium, in relation to the time of maximal PGF_2α release. Both steroid receptors populations and COX‐2 expression were similar between horns. Meanwhile, OR expression was higher in the right than in the left uterine horn. In summary, this study showed that the loss of endometrium sensitivity to progesterone by days 8–10 post‐induction of ovulation and the concomitant increase of COX‐2 expression could play a key role in the mechanism of luteolysis and somehow be related to the short corpus luteum lifespan of llamas.  相似文献   

Evaluation of low-molecular-weight heparin for the prevention of equine laminitis after colic surgery     

Geoffroy de la Rebière de Pouyade  DVM  MSc  ; Sigrid Grulke  DVM  PhD  DECVS  ; Johann Detilleux  DVM  MSc  PhD  DECVPH  ; Alexandra Salciccia  DVM  MSc  ; Denis R. Verwilghen  DVM  MSc  ; Isabelle Caudron  DVM  PhD  DECVS  ; Monika Gangl  MV  MSc  DECVS    Didier D.A. Serteyn  DVM  PhD  DECVA 《Journal of Veterinary Emergency and Critical Care》2009,19(1):113-119

Objectives – The aim of this study is to describe the prevalence of postoperative laminitis in colic cases and to determine if low-molecular-weight heparin (LMWH) is effective in preventing this complication.
Design – Retrospective clinical study.
Animals – Client-owned horses.
Interventions – SC administration of enoxaparin during the postoperative period.
Measurements and Main Results – Medical records of 360 horses undergoing surgery for colic and surviving at least 3 days were evaluated. Fifty-six horses admitted before 1995 did not receive LMWH (control group) and 304 admitted after 1995 received LMWH as a prophylaxis for laminitis (treatment group). Three grades of severity were defined for laminitis. Prevalence and severity of laminitis were compared between the 2 groups. Several parameters recorded on admission (sex, age, breed, site and nature of the disease, heart rate, PCV, gravity score, and shock score) and the administration of LMWH were tested as risk factors in the development of laminitis in a logistic regression procedure. Prevalence and grade of laminitis were significantly lower in the treatment group. Only the absence of LMWH was recognized as a significant risk factor in the logistic regression model.
Conclusions – The administration of LMWH appears to be effective in the prophylaxis of laminitis following colic surgery and may be useful in the postoperative management of these horses.  相似文献