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1.
Davood Kolbehdari Gerald B. Jansen Ian McMillan L.R. Schaeffer 《Livestock Science》2006,105(1-3):137-143
The aim of this study was to develop the linear haplotype sharing transmission disequilibrium test (LHS-TDT) method and combine this method with the simple regression method to estimate the precision of QTL positions in granddaughter designs. This precision was determined by Monte Carlo simulation in granddaughter designs. A single bi-allelic QTL at the midpoint of a linkage group and 26 markers with 1 cM intervals and with two alleles each were simulated. Three linear models, (i.e. the simple regression model, the linear haplotype sharing TDT method and the combination of these two models) were compared. The mean of absolute differences (A) between the estimated and true QTL position of each method was considered for six different scenarios consisting of combinations of a number of markers and the most frequent haplotypes. The mean of A, using the simple regression method, was 4.38 centimorgan (cM). The means of A using the LHS-TDT method were less than the simple regression method in all scenarios and ranged from 1.86 to 3.82 cM depending on the scenario. The mean of A using the combined method was more than the LHS-TDT method and less than the simple regression method. The means of A using the combined method ranged from 2.32 to 4.36 cM. Therefore, for populations similar to those population simulated in this study, the LHS-TDT was better than the simple regression method and the combined method for precision of estimated QTL position in granddaughter designs. 相似文献
2.
Journal of Plant Diseases and Protection - The present study aimed to evaluate the effects of Zataria multiflora essential oil at different concentrations (0, 100, 200, 300 and 500 ppm) on the... 相似文献
3.
Sara Sadat Aghabozorg Afjeh Behzad Boshehri Safar Hamednia Asmaolhosna Asmaolhosna Parisa Mashayekhi Mir Davood Omrani 《Iranian Biomedical Journal》2021,25(3):220
Background:Methadone therapy is a major protocol in opioid addiction cases in many health care systems. Population-based studies have shown that in addicted people, the genetic profile affects their response to methadone therapy. Therefore, this study designed to examine the frequency of two SNPs of the CYP2B6 gene (rs3745274 and rs3211371) in addicted cases in two methadone-responders and methadone non-responders groups. Methods:A total of 199 opioid-addicted individuals and 117 unaffected control subjects were genotyped for rs3745274 and rs3211371 polymorphisms of the CYP2B6 gene using the tetra-primer ARMS-PCR. Results:Results of this study revealed the significant association of rs3745274 GG (p < 0.001; OR = 0.027; 95% CI = 0.14-0.49) and GT (p < 0.001; OR = 4.04; 95% CI = 2.26-7.21) genotypes with the risk of addiction in methadone-responders. Also, a significant association between rs3745274 GG (p < 0.001; OR = 0.28; 95% CI = 0.15-0.51) and GT (p < 0.001; OR = 5.1; 95% CI = 2.8-5.28) genotypes and addiction relapse was found in methadone non-responders. Conclusion:Based on our findings, we can conclude that rs3745274 variant of CYP2B6 gene could serve as a potential biomarker, to evaluate the prognosis of addicted people fate under treatment with methadone. Key Words: Addiction, Biomarker, Methadone, Single-nucleotide polymorphism 相似文献
4.
Marques E Grant JR Wang Z Kolbehdari D Stothard P Plastow G Moore SS 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2011,128(4):305-313
The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel after accounting for the effect of DGAT1. Linkage disequilibrium information and sire heterozygosity were used to select markers for linkage analysis on bovine chromosome 14 for milk production traits in 321 Holstein animals. Results show putative milk peaks at 42 and 61 cM, both at p<0.10, a fat yield peak at 42 and 63 cM, both at p<0.05; a protein yield peak at 42 (p<0.01) and 84 cM (p<0.05); fat per cent peaks at 3 (p<0.01) and 29 cM (p<0.05), and a protein per cent peak at 4 cM (p<0.05). Once quantitative trait loci positions were established, allele substitution effects for all markers were evaluated using the same statistical model. Overlaying information between quantitative trait loci (QTL) and allele effect analysis enabled the identification (p<0.01) of 20 SNPs under the milk yield QTL, 2 under both of the fat yield peaks, 8 and 9 under the protein yield peaks, 2 and 6 for the fat per cent peaks and 5 for the protein per cent peak. One SNP in particular, ss61514555:A>C, showed association with 3 of the 5 traits: milk (p=1.59E-04), fat (p=6.88E-05) and protein yields (p=5.76E-05). Overall, combining information from linkage disequilibrium, sire heterozygosity and genetic knowledge of traits enabled the characterization of additional markers with significant associations with milk production traits. 相似文献
5.
Davood Barari Tari Jahanfar Daneshian 《Communications in Soil Science and Plant Analysis》2017,48(2):201-213
This paper considers the implications of ORYZA2000 model in simulating physiological traits of rice at different nitrogen concentrations. The experiment was conducted over the course of the growing season in 2012 and 2013 in Rice Research Institute, Deputy of Mazandaran, Iran. The variety used was Shiroudi as a high yielding variety. The considered factors were the amount of nitrogen at four levels (40, 80, 120, 160 kg N ha?1 and control) and nitrogen splitting in four levels. We compared simulated and measured grain yield, biomass, grain nitrogen, total plant nitrogen uptake, and leaf area index (LAI) by Student’s t-test of means and by absolute and normalized root mean square errors (RMSE). Results showed that grain yield was simulated with an RMSE of 411–423 kg ha?1 and a normalized RMSE of 6%. RMSE was 671–910 kg ha?1 for biomass on harvesting date. RMSE were 7–11 for grain nitrogen, and 10–13 for total plant nitrogen uptake. LAI was simulated with a normalized RMSE of 17–23%. Generally the model simulated LAI, an exceeded measured value for different nitrogen treatments. The most obvious finding that emerged from this study was that ORYZA2000 model can be applied as a supportive research tool for selecting the most appropriate strategies for rice yield improvement at various nitrogen fertilization concentrations. 相似文献
6.
In order to determine proper selection criteria for tuber yield in potato clones obtained from true potato seed (TPS) and
to evaluate relationships between tuber yield and its components, an investigation was conducted using the five check cultivars
Agria, Marfona, Draga, Agata, and Arinda, and 120 potato clones obtained from TPS. The study was conducted in an augmented
randomized complete block design with three replications. Yield and its components were recorded. Correlation coefficient
analysis showed that tuber yield had significant positive associations with number of tubers per plant, average weight per
tuber (tuber size), plant height, diameter of main stem, and number of main and secondary stems per plant, whereas its correlation
with tuber dry-matter concentration was significantly negative. Number of tubers per plant, tuber size, and plant height had
significant standardized partial regression coefficients with very small tolerance and large variance inflation factor (VIF)
values. These were considered as the first-order variables in sequential path analysis. 相似文献
7.
Mohammad Hossein Ansari Davood Hashemabadi Behzad Kaviani 《Communications in Soil Science and Plant Analysis》2017,48(18):2103-2118
The effect of cattle manure and sulfur fertilizer on seed yield and oil composition of pumpkin (Cucurbita pepo var. Styriaca) under inoculated with Thiobacillus thiooxidans was investigated in a factorial study based on a randomized complete block design. Experimental factors consisted of cattle manure (M) (M0: 0, M1: 10; and M2: 20 t ha?1), sulfur (S) (S0: 0, S1: 250; and S2: 500 kg ha?1) and T. thiooxidans (B): inoculated (B1) and non-inoculated (B0). Results demonstrated that the application of T. thiooxidans, cattle manure, and S fertilizer decreased the soil pH. The largest number of seed per fruit (367), highest fruit yield (70.57 t ha?1), seed iron (Fe) content (16.26 mg 100 g?1), and seed yield (111 kg ha?1) was obtained when 20 t ha?1 manure was applied in combination with 500 kg ha?1 S inoculated with T. thiooxidans. In this condition, the content of S, Fe, phosphorus (P), and nitrogen (N) in plant shoots was increased by 44.8%, 22.58%, 33.89%, and 10.38%, respectively, compared to the control. Moreover, the highest content of seed protein was observed in 10 t ha?1 manure and 500 kg ha?1 S fertilizer inoculated with T. thiooxidans. When 250 kg ha?1 S fertilizer was applied, 20 t ha?1 manure decreased seed P content sharply. At the rate of 500 kg ha?1 S fertilizer, the highest content of seed P was obtained from 20 t ha?1 manure. Totally, 20 t ha?1 cattle manure, along with 500 kg ha?1 S fertilizer as well as T. thiooxidans inoculation, improved oil and seed yield of medicinal pumpkin. 相似文献
8.
Jiriaei Fatemeh Kazemi-Bonchenari Mehdi Moradi Mohammad Hossein Mirmohammadi Davood 《Tropical animal health and production》2020,52(2):829-837
Tropical Animal Health and Production - The effects of feeding corn steep liquor (CSL; 420 g/kg crude protein, DM basis) along with different cereal grains on performance, digestibility,... 相似文献
9.
D. Kolbehdari G.B. Jansen L.R. Schaeffer & B.O. Allen 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2006,123(3):191-197
The performance of several transmission disequilibrium tests (TDT) for detection of quantitative trait loci (QTL) in data structures typical of outbred livestock populations were investigated. Factorial mating designs were simulated with 10 sires mated to either 50 or 200 dams, each family having five or eight full sibs. A single marker and QTL, both bi‐allelic, were simulated using a disequilibrium coefficient based on complete initial disequilibrium and 50 generations of recombination [i.e. D = D0(1 ? θ)50], where θ is the recombination fraction between marker and QTL. The QTL explained either 10% (small QTL) or 30% (large QTL) of the genetic variance for a trait with heritability of 0.3. Methods were: TDT for QTL (Q‐TDT; both parents known), 1‐TDT (only one parent known) and sibling‐based TDT (S‐TDT; neither parent known, but sibs available). All were found to be effective tests for association and linkage between the QTL and a tightly linked marker (θ < 0.02) in these designs. For a large QTL, θ = 0.01, and five full sibs per family, the empirical power for Q‐TDT, 1‐TDT and S‐TDT was 0.966, 0.602 and 0.974, respectively, in a large population, versus 0.700, 0.414 and 0.654, respectively, in a small population. For a small QTL effect, θ = 0.01, large population the empirical power of these tests were 0.709, 0.287 and 0.634. The power of Q‐TDT, 1‐TDT and S‐TDT was satisfactory for large populations, for QTL with large effects and for five full sibs per family. The 1‐TDT based on a linear model was more powerful than the normal 1‐TDT. The empirical power for Q‐TDT and 1‐TDT with a linear model was 0.978 and 0.995 respectively. TDT based on analogous linear models, incorporating the polygenic covariance structure, provided only small increases in power compared with the usual TDT for QTL. 相似文献
10.
Marashifard Masoud Karimi Aliabad Zahra Malek Hosseini Seyed Ali Asghar Darban-Sarokhalil Davood Mirzaii Mehdi Khoramrooz Seyed Sajjad 《Tropical animal health and production》2019,51(3):575-580
The aims of the present study were to investigate the prevalence of some virulence genes and also determine the antimicrobial resistance pattern of E. coli isolated from bovine with subclinical mastitis. The milk of 502 cows was collected from 8 dairy herds in the southwest of Iran. Conventional biochemical tests were used for identification of E. coli at the species level. Antimicrobial susceptibility patterns of E. coli isolates were determined by disc agar diffusion method and polymerase chain reaction (PCR) was used for detection of seven virulence genes including f17A, afaE-8, afaD-8, eaeA, cnf1, cnf2, and iucD. Seventy (13.94%) isolates of E. coli were identified in 502 milk samples. The highest rate of resistance was observed against tetracycline (18.6%), while none of the isolates were resistant to streptomycin. Eight (11.5%) out of 70 E. coli isolates carried at least one of the virulence genes. The afaD-8 was the most prevalent gene detected in 5 (7.1%) isolates. The afaE-8, iucD, and eaeA were detected in 3, 3, and 2 isolates respectively. Low prevalence of virulence factors may be indicating that most of the E. coli isolates originated from the commensal flora of cows and enter to the udders via environment contamination with feces.
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