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David A. Detweiler David S. Biller DVM James J. Hoskinson DVM Kenneth R. Harkin DVM 《Veterinary radiology & ultrasound》2001,42(2):108-112
Canine dysautonomia is an idiopathic condition resulting in loss of autonomic nervous system function. Recently, the prevalence of dogs diagnosed with dysautonomia in the mid-western United States has increased. In this study the medical records and radiographic findings in 24 dogs with dysautonomia were reviewed. A diagnosis of dysautonomia was made in 17 (71%) of the dogs in this study by postmortem examination, the remaining 7 (29%) dogs were diagnosed pharmacologically. The radiographic findings supportive of dysautonomia include aspiration pneumonia, megaesophagus, or a distended stomach, small bowel, or urinary bladder. In some instances, the disease radiographically mimicked other disorders of the gastrointestinal tract, including mechanical obstruction. 相似文献
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P. Thomas D. Breckenridge-Miller C. Detweiler 《Fish physiology and biochemistry》1997,17(1-6):109-116
The binding characteristics of 17,20,21-trihydroxy-4-pregnen-3-one (20-S) to plasma membranes prepared from the testes and sperm of spotted seatrout (Cynoscion nebulosus) were investigated using a filtration method to retain the bound 20-S. A single class of high affinity (Kd = 17.9 nM), low capacity (Bmax = 0.072 nM g-1 testes) binding sites was identified by saturation and Scatchard analyses on testicular membranes of spermiating spotted seatrout. A corresponding receptor (Kd = 22.17 nM, Bmax = 0.00261 nM ml-1 milt) was also detected in spermatozoan membrane preparations. The rates of 20-S association and dissociation were rapid, both had Thalfs of less than 1 min. Competition studies indicated that the receptor was highly specific for 20-S. 17,20-dihydroxy-4-pregnen-3-one, which had the highest affinity of the other steroids tested, had a relative binding affinity (RBA) of 14.3%. Progesterone, 11-deoxycortisol and testosterone competed with an order of magnitude less affinity (RBA's of 7.4, 1.8 and 1.1%, respectively). Estradiol displayed low affinity for the receptor (RBA = 0.4%) and cortisol did not cause any displacement at 1000-fold excess concentration. Specific 20-S receptor binding was detected in plasma membranes from testes of both spermiating and non-spermiating seatrout and on spermatozoa. Prolonged incubation of testicular fragments from a spermiating fish with gonadotropin (15 IU ml-1 human chorionic gonadotropin) or forskolin (10 µM) caused a 2–3 fold increase in membrane receptor binding. Previous studies have shown that gonadotropin-induced upregulation of the 20-S plasma membrane receptor in seatrout ovaries is required for the oocytes to become responsive to 20-S and undergo final maturation. The existence of a 20-S membrane receptor on sperm and its upregulation in the testes by gonadotropin raises the possibility that final maturation of spermatozoa in male seatrout may be regulated by a similar mechanism. 相似文献
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Malignant hyperthermia in a Greyhound 总被引：6，自引：0，他引：6
R J Bagshaw R H Cox D H Knight D K Detweiler 《Journal of the American Veterinary Medical Association》1978,172(1):61-62
A rapid rise in rectal temperature (to 45 C) in a young male Greyhound was attributed to the use of halothane and succinylcholine. Circulatory failure and death occurred within approximately 90 minutes of the onset of the hyperthermia. 相似文献
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Helal A Puchala R Detweiler GD Gipson TA Sahlu T Goetsch AL 《Journal of animal science》2011,89(12):4175-4187
Sixteen Boer goat doelings, 16 Spanish doelings, and 8 Angora doelings and 8 wethers, 283, 316, and 330 d of age initially (SEM = 5.0), respectively, were used to evaluate effects of nutrient restriction on heat energy (HE). During the first and second 10-wk phases, 8 animals of each breed were fed a 50% concentrate pelletized diet at a level adequate for maintenance and moderate energy accretion (CONT). Other animals were fed approximately 50% of these amounts in phase 1 relative to initial BW, followed by the greater level of feeding in phase 2 based on initial or actual BW when greater (REST). Average daily gain was 43, -20, 16, -78, 8, and -48 g in phase 1 (SEM = 5.0) and 26, 44, 50, 65, 27, and 32 g in phase 2 (SEM = 3.5) for Angora-CONT, Angora-REST, Boer-CONT, Boer-REST, Spanish-CONT, and Spanish-REST, respectively. Total HE was greater for CONT vs. REST in both phases (P < 0.001), greater in phase 1 for Angora than for Boer (P < 0.01) and Spanish (P < 0.01), and greatest (P < 0.01) in phase 2 among breeds for Angora [481, 347, 430, 356, 424, and 338 kJ/kg of BW(0.75) per day in phase 1 (SEM = 11.1), and 494, 479, 445, 397, 444, and 406 kJ/kg of BW(0.75) per day in phase 2 (SEM = 11.3) for Angora-CONT, Angora-REST, Boer-CONT, Boer-REST, Spanish-CONT, and Spanish-REST, respectively]. Equations describing the temporal pattern of HE (kJ/kg of BW(0.75) per day), expressed as a percentage of the wk-0 value and corrected for corresponding breed × week CONT means, in phase 1 were 95.8 ± 2.43 - (8.18 ± 1.144 × week) + (0.655 ± 0.1098 × week(2)) for Angora (R(2) = 0.58), 95.3 ± 2.63 - (4.34 ± 1.237 × wk) + (0.271 ± 0.1187 × wk(2)) for Boer (R(2) = 0.41), and 97.4 ± 2.21 - (4.69 ± 1.068 × wk) + (0.282 ± 0.1021 × wk(2)) for Spanish (R(2) = 0.53). Phase 2 equations were 78.9 ± 2.22 + (8.74 ± 1.036 × wk) - (0.608 ± 0.0095 × wk(2)) for Angora (R(2) = 0.60), 77.5 ± 2.10 + (3.30 ± 0.978 × wk) - (0.153 ± 0.0942 × wk(2)) for Boer (R(2) = 0.39), and 80.6 ± 2.50 + (4.50 ± 1.165 × wk) - (0.208 ± 0.1122 × wk(2)) for Spanish (R(2) = 0.43). These equations indicate that changes in HE in response to nutrient restriction and realimentation were more rapid and of greater magnitude in Angora vs. Boer and Spanish. The temporal pattern of decline in HE by Boer and Spanish during restriction was similar, but the subsequent rise with realimentation was slower and smaller for Boer. In conclusion, most appropriate methods of predicting change in the maintenance energy requirement during and after periods of limited feed intake may differ among breeds of goats. 相似文献
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Abstract— —In addition to physiological murmurs as found in association with fever and anemia, a number of organic murmurs resulting from cardiac lesions frequently occur in dogs. These include the pansystolic regurgitant murmur of mitral and tricuspid insufficiency and interventricular septal defect, the ejection systolic murmur of aortic and pulmonic stenosis and the continuous murmur of patent ductus arteriosus. The arterial diastolic murmur of aortic insufficiency occurs less frequently; that of pulmonic insufficiency is even less often encountered. The passive atrioventricular diastolic murmurs and atriosystolic murmurs of relative or absolute mitral or tricuspid stenosis are extremely rare. The most frequently heard abnormal transients in the dog are the ventricular diastolic gallop, the systolic click, and the presystolic atrial gallop. Splitting of the second heart sound is a fairly common finding in areas where heartworm heart disease is prevalent. Paradoxical splitting of S2 is only occasionally observed. Résumé— —En surcoit des souffles physiologiques comme constatés en association à la fiévre et l'anémie, de nombreux souffles organiques résultant de lésions cardiaquessurvenant fréquemment chez le chien. Ceux-ci comprennent le souffle pansystolique régurgitant d'insuffisance mitrale et tricuspide et de défaut de la cloison interventriculaire, le souffle d'éjection systolique de retricissement aortique et pulmonaire et le souffle continuel patent du canal arteriosus. Le souffle arteriel diastolique de l'insuffisance aortique se présente moins fréquemment; celui de l'insuffisance pulmonaire survient encour moins souvent. Les souffles passifs atrioventriculaires diastoliques et les souffles atriosystoliques de retrecissement relatifs ou obsolus mitral ou tricuspide sont extrêmement rares. Les transitions anormalies les plus souvent survenues chez le chien sont le galop ventriculaire diastolique, le clic systolique, et le galop artériel presystolique. La séparation du son du second coeur et assez commune dans les régions ou les maladies cardiaques prévalent. La séparation paradoxale de S est occasionnellement observée. Zusammenfassung— —Ausser physiologischen Geraeuschen in Verbindung mit Fieber und Anaemic treten eine Anzahl von organischen Geraeuschen als Resultat von Herzstoerungen haeufig bei Hunden auf. Diese umfassen das pansystolische rueckfliessende Geraeusch der mitralen und trik-uspidalen Insuffizienz und des interventrikularen Septum-Defekts, das Ejektions-systolische Geraeusch der Aorten- und Pulmonal-Stenose und das Dauer-Geraeusch des offenen Duktus arteriosus. Das arterielle diastolische Geraeusch der Aorten-Insuffizienz tritt weniger haeufig auf, das der Pulmonal-Insuffizienz noch seltener. Die passiven atrioventrikulaeren diastolischen Geraeusche und atrio-systolischen Geraeusche der relativen oder absoluten mitralen oder trikuspidalen Stenose sind ausserordentlich selten. Die am haeufigsten gehoerten anormalen vorueber-gehenden Geraeusche beim Hund sind der ventrikulaere diastolische Galopp-Rhythmus, das systolische Einschnappen und der praesystolische atriale Galopp-Rhythmus. Spaltung des zweiten Herztones ist eine ziemlich haeufiger Befund in Gegenden, wo die Herzwurm-Krankheit haeufig ist. Paradoxe Spaltung des zweiten Tones wird nur gelegentlich beobachtet. 相似文献
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Anne H Lee Katelyn B Detweiler Tisha A Harper Kim E Knap Maria R C de Godoy Kelly S Swanson 《Journal of animal science》2021,99(8)
Osteoarthritis (OA) affects about 90% of dogs > 5 yr of age in the United States, resulting in reduced range of motion, difficulty climbing and jumping, reduced physical activity, and lower quality of life. Our objective was to use activity monitors to measure physical activity and identify how activity counts correlate with age, body weight (BW), body condition score (BCS), serum inflammatory markers, veterinarian pain assessment, and owner perception of pain in free-living dogs with OA. The University of Illinois Institutional Animal Care and Use Committee approved the study and owner consent was received prior to experimentation. Fifty-six client-owned dogs (mean age = 7.8 yr; mean BCS = 6.1) with clinical signs and veterinary diagnosis of OA wore HeyRex activity collars continuously over a 49-d period. Blood samples were collected on day 0 and 49, and dog owners completed canine brief pain inventory (CBPI) and Liverpool osteoarthritis in dogs (LOAD) surveys on day 0, 21, 35, and 49. All data were analyzed using SAS 9.3 using repeated measures and R Studio 1.0.136 was used to generate Pearson correlation coefficients between data outcomes. Average activity throughout the study demonstrated greater activity levels on weekends. It also showed that 24-h activity spiked twice daily, once in the morning and another in the afternoon. Serum C-reactive protein concentration was lower (P < 0.01) at day 49 compared to day 0. Survey data indicated lower (P < 0.05) overall pain intensity and severity score on day 21, 35 and 49 compared to day 0. BW was correlated with average activity counts (P = 0.02; r = −0.12) and run activity (P = 0.10; r = −0.24). Weekend average activity counts were correlated with owner pain intensity scores (P = 0.0813; r = −0.2311), but weekday average activity count was not. Age was not correlated with total activity count, sleep activity, or run activity, but it was correlated with scratch (P = 0.03; r = −0.10), alert (P = 0.03; r = −0.13), and walk (P = 0.09; r = −0.23) activities. Total activity counts and activity type (sleep, scratch, alert, walk, and run) were not correlated with pain scored by veterinarians, pain intensity or severity scored by owners, or baseline BCS. Even though the lack of controls and/or information on the individual living conditions of dogs resulted in a high level of variability in this study, our data suggest that the use of activity monitors have the potential to aid in the management of OA and other conditions affecting activity (e.g., allergy; anxiety). 相似文献
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Detweiler DA Johnson LR Kass PH Wisner ER 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(5):1080-1084
BACKGROUND: Sinonasal disease is common in cats; chronic inflammatory disease and neoplasia are diagnosed most frequently. Radiographic and computed tomographic (CT) findings in nasal disease have been reported, although involvement of other cranial structures has not been fully described to our knowledge. HYPOTHESIS: We hypothesized that neoplastic or inflammatory obstruction of the auditory tube associated with sinonasal disease could result in CT evidence of effusive bulla disease in affected cats. ANIMALS: 46 cats with sinonasal disease, 18 control cats. METHODS: CT images acquired in cats with (n = 46) and without (n = 18) sinonasal disease were reviewed for evidence of concurrent bulla effusion. CT findings of soft tissue or fluid opacity within the tympanic bulla or thickening of the bone of the bullae were considered evidence of effusive bulla disease. RESULTS: The prevalence of bulla effusion in cats with sinonasal disease was 28% (13/46) and was significantly higher than that observed in cats without sinonasal disease (1/18, P = .043). CT findings that were found in association with effusive bulla disease included imaging features of sinusitis and nasopharyngeal disease. The most common neoplasm associated with bulla effusion was nasopharyngeal lymphoma. Bulla effusion was not observed in any cat with nasal carcinoma. CONCLUSIONS AND CLINICAL IMPORTANCE: Findings of this study suggest that auditory canal dysfunction may play a larger role in feline sinonasal disease than was previously recognized. The implications of these findings for management of cats with chronic inflammatory or neoplastic sinonasal disease require further investigation. 相似文献
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