Cyclic AMP-induced repair of zebrafish spinal circuits     

Bhatt DH  Otto SJ  Depoister B  Fetcho JR 《Science (New York, N.Y.)》2004,305(5681):254-258

Neurons in the human central nervous system (CNS) are unable to regenerate, as a result of both an inhibitory environment and their inherent inability to regrow. In contrast, the CNS environment in fish is permissive for growth, yet some neurons still cannot regenerate. Fish thus offer an opportunity to study molecules that might surmount the intrinsic limitations they share with mammals, without the complication of an inhibitory environment. We show by in vivo imaging in zebrafish that post-injury application of cyclic adenosine monophosphate can transform severed CNS neurons into ones that regenerate and restore function, thus overcoming intrinsic limitations to regeneration in a vertebrate.  相似文献   

Comparative diagnostic evaluation of OMP31 gene based TaqMan® real-time PCR assay with visual LAMP assay and indirect ELISA for caprine brucellosis     

Saini  Suman  Gupta  V. K.  Gururaj  K.  Singh  D. D.  Pawaiya  R. V. S.  Gangwar  N. K.  Mishra  A. K.  Dwivedi  Deepak  Andani  Dimple  Kumar  Ashok  Goswami  T. K. 《Tropical animal health and production》2017,49(6):1253-1264

Tropical Animal Health and Production - Brucellosis is one of the leading causes of abortion in domestic animals that imposes costs on both economy and society. The disease is highly zoonotic and...  相似文献   

Detection of the presence of Coxiella burnetii in a case of goat abortion: a first report from India     

Rajagunalan  S.  Gururaj  K.  Lakshmikantan  U.  Murugan  M.  Ganesan  A.  Sundar  A.  Sureshkannan  S.  Andani  Dimple  Pawaiya  Rajveer Singh 《Tropical animal health and production》2019,51(4):983-986

Abortion is a major cause of economic loss to the goat industry. Coxiella burnetii the causative agent of Q fever is an important zoonotic agent known to be prevalent worldwide. In the present investigation, we detected the presence of Coxiella burnetii by the modified Ziehl Neelsen method of staining and its DNA by trans-PCR assay in the placenta obtained from the aborted goat. We also ruled out other common causes of abortion in this case. Based on a literature survey, this is the first report on the direct detection of Coxiella burnetii from an aborted goat to be reported from India.

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