排序方式： 共有24条查询结果，搜索用时 250 毫秒
1.
Satoshi KAMBAYASHI Masaya IGASE Kosuke KOBAYASHI Ayana KIMURA Takako SHIMOKAWA MIYAMA Kenji BABA Shunsuke NOGUCHI Takuya MIZUNO Masaru OKUDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1405-1412
Hypoxic conditions in various cancers are believed to relate with their
malignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a major
regulator of the response to low oxygen. In this study, we examined HIF-1α expression in
canine lymphoma using cell lines and clinical samples and found that these cells expressed
HIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol,
suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using
NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor.
Our results suggest that HIF-1α contributes to the proliferation and/or survival of canine
lymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat canine
lymphoma. 相似文献
2.
Tatsuro Suzuki Takahiro Noda Toshikazu Morishita Koji Ishiguro Shiori Otsuka Jotaro Aii Ayana Nakano Kenjiro Katsu Katsuhiro Matsui Ryoma Takeshima Noriaki Aoki Takashi Hara Takahiro Hara Rie Satoh 《Plant Breeding》2023,142(5):711-720
The concentration of amylose, which is synthesised using granule-bound starch synthase, affects the physical properties of food. However, no studies have focused on starch properties and physical characteristics of low-amylose buckwheat. Here, we hypothesised that low-amylose buckwheat would be useful to produce new buckwheat products because low-amylose characteristics change the texture of buckwheat food. In this study, we bred relatively low-amylose buckwheat compared to wild type and investigated the causative genes of the traits, starch properties and physical properties of noodles. In the GBSSa mutant, the amylose concentration was lower than that in the wild type. Compared with the wild type, the mutant exhibited the following traits: Amylose concentration decreased by approximately 2%, setback in the Rapid Visco Analyzer decreased by 30 points and the physical characteristics of noodles in the sensory analysis were soft and sticky. These results suggest that this trait may be useful for changing the texture of foods. In addition, the mutant is promising for producing new foods with physical characteristics that are different from those of the wild type. 相似文献
3.
Asrat Asfaw Gebremedhen Woldegiorgis Semagn A. Kolech Gedif Mulugeta Dinka Mulugeta Abigail Ngugi 《Acta Agriculturae Scandinavica, Section B - Plant Soil Science》2018,68(7):596-607
Micronutrient deficiencies in diets, including iron (Fe) and zinc (Zn), are an important public health problem across population in Ethiopia. Potato is a modest source of dietary nutrients. The purpose of this study was to assess the mineral (Fe & Zn) composition of potato germplasm in Ethiopia and grower's willingness to try new potato types. The Fe and Zn contents were assessed in peeled tubers of popular farmer varieties, and newly introduced Andean diploid group Phureja accessions and improved tetraploid clones grown in multi-location trials. Grower's preferences for the new potato types was assessed using a participatory approach. Significant variations in mineral and tuber yield traits exist among the germplasm assessed and broad-sense heritability appears to be high for most traits measured, suggesting that progress through breeding can be made among these materials. However, the slightly negative correlation of tuber yield with Fe and Zn content and user appreciation traits found in this study suggests that progress in improving crops for yield and enhanced Fe and Zn concentrations with end-user acceptable quality will be challenging. The results from this study provide baseline information on Fe and Zn composition of many popular farmer varieties in Ethiopia and end-user preference criteria for evaluating new potato varieties that would help to orient the biofortification breeding to the conditions and preference of farmers. 相似文献
4.
5.
A total of 415 sorghum (Sorghum bicolor (L.) Moench) accessions representing different regions of Ethiopia, Eritrea and a group of introduced lines were evaluated
for 15 quantitative characters to determine the extent and geographical pattern of morphological variation. The extent of
variation was highly pronounced for agronomically important characters for sorghum. These characters included plant height,
days for 50% flowering, peduncle exsertion, panicle length and width, number and length of primary branches per panicle and
thousand seed weight. Significant regional variation was also observed for most of the characters. The results implied that
environmental factors such as altitude, rainfall, temperature and growing period are important in regional variation. Mean
for plant height and for days for 50% flowering showed clinal variation along the gradients of rainfall pattern and growing
period in Ethiopia. Moreover, there were significant positive correlation coefficients between most of the characters. This
included the correlation between agronomic characters of primary interest in sorghum breeding such as plant height and days
for 50% flowering and also between various characters and the altitude of the collection sites. The implications of the results
in plant breeding, germplasm collection and conservation as well as the probable sources of the wide range of variation are
discussed.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
6.
Dinka Grubišić Ljerka Oštrec Tanja Gotlin Čuljak Sylvia Blümel 《Journal of pest science》2007,80(1):21-27
Potato cyst nematodes (PCN) Globodera rostochiensis (Wollenweber, 1923) Behrens, 1975 and Globodera pallida (Stone, 1973) Behrens, 1975 are the most troublesome pests of potatoes worldwide. Since 1968 there have been no investigations
of the presence of PCN in ware potato lands in Croatia although these pests were recognised as an A1 plant-health quarantine
species. After the first discovery of G. rostochiensis in the locality of Belica (Medjimurska County) in 2001, intensive monitoring of the distribution of PCN in Croatia started.
In 2001 G. rostochiensis was detected in 55% of soil samples taken in ware potato lands. In 2002 G. rostochiensis was detected in 4.1% of soil samples and in 0.08% of soil samples in mixed populations with G. pallida. The pathotype Ro1 was found in all tested populations and Ro1 and Pa 2/3 were detected in populations from localities Vidovec,
Ivanovec and Sivice. In 2003 G. rostochiensis was detected in 1.03% of soil samples, and also in 12.8% of soil samples collected in 2004. In 2003 cysts of G. rostochiensis were detected in several seed potato fields. These results indicate the urgent need for the application of further control
measures to determine the presence and distribution of PCN in ware and seed potato lands in Croatia, in order to prevent the
spread of PCN to non-infested areas. Integrated management strategies, neglected until 2001, have now been implemented and
will prevent the build-up of infestation and replace the previous practices of monoculture, the use of short rotations and
growing susceptible cultivars. 相似文献
7.
Alenka Tofant Marija Vu
emilo
eljko Pavi
i&#x; Dinka Mili&#x; 《Livestock Science》2006,102(3):243-247
Hydrogen peroxide is used more and more as the water and wastewater as well as slurry disinfectant. Its advantages over other oxidants are nontoxic, harmless, and environmentally acceptable by products. The basic task in the disinfection of slurry is to destroy or remove infectious microorganisms so that the slurry cannot transmit disease producing agents, when disposed on the land or into waters.
In the present study the effect of hydrogen peroxide disinfectant with catalytic action of metal ions, silver and ferrous, was investigated in the hygienization process of pig and cattle slurry.
In order to determine the optimal concentration of disinfectant, the effect of a range of final concentrations of hydrogen peroxide alone and with metal ions was investigated. Organoleptic, physicochemical and bacteriologic parameters were analyzed for wastewater quality assessment in accordance with standard methods.
The results illustrated an improvement of organoleptic properties: color and odor, the oxidation of organic matter across reduction of BOD5 and ammonium content of the treated slurries as well as a decrease of aerobic mesophilic bacteria and total coliform bacteria numbers.
This investigation indicated that the disinfection of slurry with the oxidative compounds with hydrogen peroxide basis and catalytic action of silver and ferrous ions can be recommended for its bactericidal and oxidative effect. 相似文献
8.
Dinka Vujanič-Varga V. Ognjanov Jelica Balaž Ksenija Macet Marija Krstič 《Euphytica》1994,77(1-2):155-159
Summary During the period 1988–90, several germplasm collecting trips were made to all republics of former Yugoslavia. A total of
56 old apple cultivars, many of which are represented in up to 5 types, 38 old pear cultivars and 367 genotypes of vineyard
peaches were collected. The availability of so much genetic and genotypic wealth made it possible to start apple disease resistance
breeding and peach cultivar and rootstock breeding programmes. 相似文献
9.
This study reconstructed 21 years of household cattle population data in key resource (tula wells) and non-key resource (pond-water) rangelands in southern Ethiopia, as well as 15 years of government cattle breed conservation ranch data, to analyze the relationship between long-term rainfall and cattle population dynamics. For the key-and-non-key resource rangelands, we assessed the reproductive life of cows and the number of calves. For both the communal and ranch systems, we analyzed impacts of multiple droughts on calving rates and herd die-offs. Relationships between pre-drought and post-drought cattle populations were used to evaluate evidence of density-dependence. Breeding females in the key resource tula well rangelands had a longer reproductive life than in the pond-water rangelands, and they produced more calves per reproductive life. Average calving rates were 55% for the communal and 52% for the ranch. Greater reductions in calving rates during droughts implied reduced herd growth potential. Breeding females and immature animals were influenced to a much greater degree by inter-annual rainfall variability than were mature males. The data showed a downward spiral for the total cattle holdings over a 21-year period, with a decline of 54%. The evidence of density-dependence was relatively important at the local land use level as compared with the regional level. Cattle population below carrying capacity under ranch management did not reduce herd die-offs, suggesting that rainfall variability, not density, had greater influence on cattle population dynamics. Long-term trends of cattle populations in the communal and ranch systems synchronized with mean deviations of rainfall. Our results indicate that rainfall variability under the different management systems strongly influenced the dynamics of cattle population, calving rates and mortality. The claim that ranching could be a superior model for range management in Borana over the communal system was not confirmed. The decline in cattle population in southern Ethiopia indicates a need for improved drought management policy. The evidence that droughts were more harmful to breeding females and immature animals than to mature males suggested that drought management needs to focus on herd recruitment potential. For the herders in southern Ethiopia, drought management involved herd mobility and accumulation of herds during periods of favourable rainfall. In the future, the importance of government ranch could be in breed conservation for the maintenance of the Borana cattle breed through distribution of bulls during the drought recovery phase. 相似文献
10.