Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy     

Mariarosaria Conte  Elisabetta Fontana  Angela Nebbioso  Lucia Altucci 《Marine drugs》2021,19(1)

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Relationship between serum cortisol levels and some physiological parameters following reining training session in horse          下载免费PDF全文

Stefania Casella  Irene Vazzana  Elisabetta Giudice  Francesco Fazio  Giuseppe Piccione 《Animal Science Journal》2016,87(5):729-735

The changes of cortisol, red blood cells (RBC), hemoglobin (Hb), hematocrit (Hct), heart rate (HR), respiratory rate (RR) and rectal temperature (RT) were evaluated after a reining training session in eight Quarter Horses. All parameters were measured before exercise (T0), immediately after exercise (T1), 1 h after exercise (T2), 2 h after exercise (T3) and 24 h after exercise (T4). One‐way analysis of variance (ANOVA) for repeated measures, followed Bonferroni's post hoc test, showed a significant effect of the reining training session (P < 0.0001) on cortisol, RBC, Hb, Hct, HR, RR and RT. Simple linear regression analysis showed the positive correlation (P < 0.05) between cortisol changes and variations of studied parameters in T1, T3 and T4. Exercise‐induced cortisol concentrations reflect the physiological response of reining training, suggesting that the changes observed are useful to assess the performance in reining horses and their reining training adaptability.  相似文献   

Pasteurized tumoral autograft and adjuvant chemotherapy for the treatment of canine distal radial osteosarcoma: 13 cases     

Morello E  Vasconi E  Martano M  Peirone B  Buracco P 《Veterinary surgery : VS》2003,32(6):539-544

OBJECTIVE: To report outcome in 13 dogs with distal radial osteosarcoma, without evidence of metastasis, treated by a combination of adjuvant chemotherapy and a pasteurized autograft limb-sparing procedure. STUDY DESIGN: Prospective clinical study. ANIMALS: Thirteen dogs with distal radial osteosarcoma. METHODS: Limb-sparing procedure was performed using an autograft from the excised tumoral segment, pasteurized at 65 degrees C for 40 minutes. Adjuvant chemotherapy (cisplatin or cisplatin and doxorubicin) was administered in all dogs. RESULTS: Mean and median survival times were 531 and 324 days, respectively (range, 180 to 1,868 days). Overall survival was 100% at 6 months, 50% at 12 months, 44% at 18 months, and 22% at 24 months. Lung metastasis occurred in 5 (38%) dogs. Observed complications were local recurrence (2 dogs, 15%), allograft infection (4 dogs, 31%), and implant failure (3 dogs, 23%). Limb function was good in 12 dogs (92%) and fair in 1 dog. CONCLUSIONS: Pasteurized bone autograft derived from the tumoral bone segment was an effective alternative to cortical bone allograft for limb sparing in canine distal radial osteosarcoma, in terms of feasibility, pattern of healing, complications, and survival. CLINICAL RELEVANCE: Use of a pasteurized bone autograft eliminates the need for a canine bone allograft bank and has the added advantage of good fit to the recipient site.  相似文献   

Pasteurized tumoral autograft as a novel procedure for limb sparing in the dog: A clinical report     

Buracco P  Morello E  Martano M  Vasconi ME 《Veterinary surgery : VS》2002,31(6):525-532

OBJECTIVE: To evaluate use of a pasteurized tumoral autograft prepared from the resected primary bone neoplasm for limb sparing in a dog with distal radial osteosarcoma (OSA). STUDY DESIGN: Clinical case report. ANIMALS: A 9-year-old male Maremma shepherd dog. METHODS: After right distal radial OSA removal, the tumoral autograft was pasteurized. The excised bone segment was placed in a sterile watertight box containing sterile saline solution preheated to 65 degrees C in a water bath. The box was kept immersed in the water bath at 65 degrees C for 40 minutes to kill the tumor cells. The autograft was then fixed in the host with a plate and screws based on standard AO/ASIF technique for carpal arthrodesis. Three doses of cisplatin (70 mg/m(2) intravenously) were administered, 3 weeks apart; the initial dose was administered the day after surgery. RESULTS: The autograft was incorporated in a manner comparable to an allograft, and after 708 days, the metallic implants were removed. A 1-month activity restriction as well as spoon splint to protect the leg from a full loading were used thereafter. Limb function was fair to good, and the dog remains disease free after 56 months. CONCLUSIONS: A pasteurized autograft consisting of the resected primary bone neoplasm is a valid alternative to a cortical bone allograft for limb sparing in dogs with appendicular OSA in terms of feasibility and pattern of healing. CLINICAL RELEVANCE: This procedure can be an alternative method of limb sparing when difficulties are encountered in establishing and maintaining a canine bone allograft bank.  相似文献   

Antioxidant systems and lymphocyte proliferation in the horse,sheep and dog     

Chiaradia E  Gaiti A  Scaringi L  Cornacchione P  Marconi P  Avellini L 《Veterinary research》2002,33(6):661-668

To better define the species-specific antioxidant systems and to ascertain the influence of the intracellular redox status on the immune system of different animal species, we determined lymphocyte glutathione peroxidase (GSHPx) activity, plasmatic glutathione levels (GSH) and the effect of H2O2 on the responsiveness of lymphocytes to proliferative stimuli. Among the three species considered, sheep presented the lowest plasmatic GSH and the highest lymphocyte GSHPx activity. On the contrary, dogs showed an inverted pattern (high GSH - low GSHPx). Horses displayed intermediate values for both parameters analysed. The effect of H2O2 on the proliferative capacity of lymphocytes was the same for all three species; the 200 microM dose in particular was strongly inhibiting. Each species, however, showed different rates of inhibition: sheep exhibited the highest sensitivity to the antiproliferative effect of H2O2. Our results confirmed that high H2O2 concentrations (200 microM) are noxious for the cellular functions of all animals; however this effect is mediated by a rigorously species-specific relationship between the intracellular reactive oxygen species (ROS) and the molecular systems involved in cell proliferation.  相似文献   

Co-occurrence of papillomas related to Equus caballus papillomavirus type 2 and cutaneous habronemiasis     

G. Vichi  I. Porcellato  L. Mechelli  G. Fantauzzo  E. Razzuoli  P. Modesto  S. Mecocci  C. Brachelente 《Equine Veterinary Education》2022,34(5):e193-e197

The present report describes a case of cutaneous papillomatosis related to equine papillomavirus type 2 (EcPV2) with concomitant cutaneous habronemiasis. A 2-year-old female Pura Raza Española horse was referred for a dermatological evaluation because of the onset of cutaneous multifocal, nodular lesions on the face characterised by a warty and partially ulcerated overlying epidermis. Multiple biopsies were taken from these lesions, and cutaneous viral papillomas with a concomitant severe focal eosinophilic dermatitis with intralesional Habronematidae nematode larvae were diagnosed. Immunohistochemistry revealed papillomaviral capsid protein L1 in the epidermal proliferative lesion, confirming the presence of a productive infection. Rt-qPCR confirmed the presence of EcPV type 2. To the authors’ knowledge, this is the first report of EcPV2-related papillomas with concurrent habronemiasis.  相似文献   

Deadly Outbreak of Iron Storage Disease (ISD) in Italian Birds of the Family Turdidae     

Silvia PAVONE  Sonia SALAMIDA  Ivan PECORELLI  Elisabetta ROSSI  Elisabetta MANUALI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(9):1209-1212

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Clinical chemistry parameters of piglets at weaning are modulated by an oral,low-dose interferon-α treatment     

Razzuoli  E.  Dotti  S.  Archetti  I. L.  Amadori  M. 《Veterinary research communications》2010,34(1):189-192

Clinical chemistry parameters were investigated in piglets weaned at 22 and 28 days. The effects of an oral, low-dose interferon (IFN)-α treatment at weaning were evaluated as well. The trial was carried out on 59 piglets from the same farm, allocated to three groups: the first and the second groups were weaned at 28 and 22 days of age, respectively; the third group was weaned at 22 days and orally treated at weaning with IFN-α at a low dose (1 IU human lymphoblastoid IFN-α /kg body weight in drinking water) for 10 consecutive days. The results of the field trial confirmed that weaning is one of the main stressing events for pigs at intensive farms. In particular, these findings are based on a dramatic increase in serum haptoglobin levels after weaning in the three groups under study. Results also indicated that early weaning at 22 days implies higher environmental adaptation. In such animals, an oral, low-dose IFN-α treatment gave rise to a peculiar, negative, acute-phase response (reduced levels of serum albumin) and to significantly lower α-globulin concentrations in sera. Taken together, IFN-α was shown to modulate inflammatory responses to early weaning stress.

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Application of hexanal,E-2-hexenal,and hexyl acetate to improve the safety of fresh-sliced apples     

Lanciotti R  Belletti N  Patrignani F  Gianotti A  Gardini F  Guerzoni ME 《Journal of agricultural and food chemistry》2003,51(10):2958-2963

The aims of this work were to evaluate the effects of different concentrations of hexanal, (E)-2-hexenal, hexyl acetate, and their mixtures on the fate of pathogenic species such as Escherichia coli, Salmonella enteritidis, and Listeria monocytogenes inoculated in model systems as well as the antimicrobial activity against the target species of the chosen molecules when added to the packaging atmosphere of inoculated fresh-sliced apples. The result obtained in this work pointed out the potential use of compounds such as hexanal, (E)-2-hexenal, and hexyl acetate for both the extension of shelf life and an improvement of hygienic safety of "minimally processed foods". In fact, hexanal, (E)-2-hexenal, and hexyl acetate had a significant inhibitory effect against pathogen microorganisms frequently isolated from raw materials (E. coli, S. enteritidis, and L. monocytogenes) when inoculated in both model and real systems. In this last condition, these compounds, at the levels used (150, 150, and 20 ppm for hexanal, hexyl acetate, and (E)-2-hexenal, respectively), displayed a bactericide effect on L. monocytogenes and they exhibited significant extensions of lag phase of E. coli and S. enteritidis inoculated at levels of 10(4)-10(5) CFU/g.  相似文献   

Fair game for chimpanzees     

Visalberghi E  Anderson J 《Science (New York, N.Y.)》2008,319(5861):282-284

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