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FEDERICA MORANDI ROBERT C. COLE RITA L. ECHANDI GREGORY B. DANIEL 《Veterinary radiology & ultrasound》2007,48(3):286-291
Transsplenic portal scintigraphy using sodium pertechnetate is superior to per-rectal portal scintigraphy due to improved visualization of the portal vasculature with decreased patient and personnel exposure. The purpose of this study was to describe the use of 99mTc-mebrofenin, the radiopharmaceutical of choice for the evaluation of hepatic function, in place of pertechnetate for transsplenic portal scintigraphy in normal dogs. Sixteen juvenile dogs underwent transsplenic portal scintigraphy using 37-130 MBq 99mTc-mebrofenin in a 0.2-0.5 ml volume. After the initial dynamic acquisition obtained at 4 frames/s in right lateral recumbency, static right lateral, and ventral views were obtained at 5, 10, 15, 20, 25, 30, 40, 50, and 60 min. A nuclear angiogram of the splenic and portal veins was visible in all dogs, followed by rapid distribution of the radiopharmaceutical in the liver. Hepatic morphology was more easily defined than with pertechnetate. Transit time could not be calculated due to the high hepatic extraction of 99mTc-mebrofenin. Mean +/- SD shunt fraction was 0.8 +/- 0.8%. Time to peak liver activity was 3.1 +/- 1.1 min, and hepatic excretion T1/2 was 19.4 +/- 6.3 min. No visible blood pool and cardiac activity was seen after 5 min. The mean +/- SD time to visualization of defined biliary activity was 8.8 +/- 2.9 min. Absorption from the spleen was significantly higher than that reported for pertechnetate (87.9 +/- 8.2%, vs. 52.5 +/- 19.1%). 99mTc-mebrofenin can be used in place of pertechnetate for transsplenic portal scintigraphy, with the advantage of combining quantitative parameters of liver function with the already known advantage of transsplenic portal scintigraphy. 相似文献
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PASCALINE PEY MASSIMO VIGNOLI HENDRIK HAERS LUC DUCHATEAU FEDERICA ROSSI JIMMY H. SAUNDERS 《Veterinary radiology & ultrasound》2011,52(5):560-567
Contrast‐enhanced ultrasonography is useful in differentiating adrenal gland adenomas from nonadenomatous lesions in human patients. The purposes of this study were to evaluate the feasibility and to describe contrast‐enhanced ultrasonography of the normal canine adrenal gland. Six healthy female Beagles were injected with an intravenous bolus of a lipid‐shelled contrast agent (SonoVue®). The aorta enhanced immediately followed by the renal artery and then the adrenal gland. Adrenal gland enhancement was uniform, centrifugal, and rapid from the medulla to the cortex. When maximum enhancement was reached, a gradual homogeneous decrease in echogenicity of the adrenal gland began and simultaneously enhancement of the phrenicoabdominal vessels was observed. While enhancement kept decreasing in the adrenal parenchyma, the renal vein, caudal vena cava, and phrenicoabdominal vein were characterized by persistent enhancement until the end of the study. A second contrast enhancement was observed, corresponding to the refilling time. Objective measurements were performed storing the images for off‐line image analysis using Image J (ImageJ©). The shape of the time–intensity curve reflecting adrenal perfusion was similar in all dogs. Ratios of the values of the cortex and the medulla to the values of the renal artery were characterized by significant differences from initial upslope to the peak allowing differentiation between the cortex and the medulla for both adrenal glands only in this time period. Contrast‐enhanced ultrasonography of the adrenal glands is feasible in dogs and the optimal time for adrenal imaging is between 5 and 90 s after injection. 相似文献
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FEDERICA ROSSI SILVIA RABBA MASSIMO VIGNOLI HENDRIK HAERS ROSSELLA TERRAGNI JIMMY H. SAUNDERS 《Veterinary radiology & ultrasound》2010,51(2):173-177
Four dogs with an accessory spleen are described. The accessory spleens appeared as a round‐to‐triangular structure located in the perisplenic area. They were homogeneous and isoechoic with the adjacent spleen. Contrast‐enhanced ultrasound was performed using a second generation microbubble contrast medium (sulfur hexafluoride). The type and timing of enhancement of the accessory spleen was similar to that of the parent spleen. Contrast‐enhanced ultrasound is a noninvasive modality useful in distinguishing an accessory spleen from a mass of another origin. 相似文献
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RITA L. ECHANDI FEDERICA MORANDI SHELLEY J. NEWMAN AMY HOLFORD 《Veterinary radiology & ultrasound》2007,48(3):243-245
A 12-year-old neutered female Pembroke Welsh Corgi had a 2-month history of a progressive, productive cough nonresponsive to therapy. Mild pleural effusion, right middle lung lobe collapse, and multiple subpleural nodular lesions were detected in thoracic radiographs and computed tomography (CT) images. Histopathologic diagnosis of the pleural nodules was mesothelioma. Mesothelioma should be considered in patients where pleural masses are detected in radiographs or CT images. 相似文献
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FEDERICA MORANDI JAMIE L. MAYS SHELLEY J. NEWMAN WILLIAM H. ADAMS 《Veterinary radiology & ultrasound》2007,48(3):246-249
A 10-year-old neutered female Pug was evaluated for a left adrenal mass detected previously by ultrasonography. Using computed tomography, a fat-attenuating, rim-enhancing left adrenal mass and a homogeneous, soft-tissue attenuating, intensely enhancing right adrenal mass were found. A left adrenalectomy and right adrenal biopsy were performed and the final diagnosis was bilateral adrenal adenomas and myelolipomas. Myelolipomas are rare, benign, endocrinologically inactive tumors composed of well-differentiated adipose tissue and a variable amount of hematopoietic cells of both lymphatic and myeloid lineages, which may account for the different appearance on tomographic images. 相似文献
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GABRIELA SEILER FEDERICA ROSSI MASSIMO VIGNOLI RACHEL CIANCIOLO TIFFANY SCANLON URS GIGER 《Veterinary radiology & ultrasound》2007,48(6):544-549
Computed tomography (CT) features of four immature to young adult dogs with osteomyelitis of the skull are described. Trauma or bite wounds were the cause of infection and Staphylococcus aureus was the most common pathogen. CT features were a combination of soft tissue thickening, bone lysis, and bone proliferation. Bone lysis was extensive in some dogs with a moth-eaten appearance and involved the calvarium, base of the skull, the frontal sinuses, and the temporomandibular joint. In other dogs it was more focal with thinning of the bone rather than complete lysis. Bone proliferation also varied in appearance from irregular palisading or spiculated to expansion and septation of the frontal bone. Sequestrum formation was seen in one dog. Widespread infection in one dog involved the tympanic bullae and the temporomandibular joint. Lysis of the calvarium resulted in bacterial meningitis in two dogs. One dog was euthanized and three were treated with surgical curettage of the affected bone and antibiotic therapy which resulted in resolution of the clinical signs in one dog whereas two dogs had recurrent disease. CT was very helpful for characterizing extent and localization of the infection. Despite the aggressive CT features, osteomyelitis should be considered especially in young animals with a history of trauma or bite wounds. The pathophysiology of skull bone infections is discussed. 相似文献
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DAVIDE D. ZANI DVM PhD LAURA ROMANÒ DVM MASSIMILIANO SCANDELLA DVM PhD MARCO RONDENA DVM PhD PIETRO RICCABONI DVM PhD NICOLA MORANDI DVM MAURO DI GIANCAMILLO DVM ANGELO G. BELLOLI DVM DAVIDE PRAVETTONI DVM PhD 《Veterinary surgery : VS》2008,37(8):801-808
Objective— To report clinical signs, diagnostic and surgical or necropsy findings, and outcome in 2 calves with spinal epidural abscess (SEA). Study Design— Clinical report. Animals— Calves (n=2). Methods— Calves had neurologic examination, analysis and antimicrobial culture of cerebrospinal fluid (CSF), vertebral column radiographs, myelography, and in 1 calf, magnetic resonance imaging (MRI). A definitive diagnosis of SEA was confirmed by necropsy in 1 calf and during surgery and histologic examination of vertebral canal tissue in 1 calf. Results— Clinical signs were difficulty in rising, ataxia, fever, apparent spinal pain, hypoesthesia, and paresis/plegia which appeared 15 days before admission. Calf 1 had pelvic limb weakness and difficulty standing and calf 2 had severe ataxia involving both thoracic and pelvic limbs. Extradural spinal cord compression was identified by myelography. SEA suspected in calf 1 with discospondylitis was confirmed at necropsy whereas calf 2 had MRI identification of the lesion and was successfully decompressed by laminectomy and SEA excision. Both calves had peripheral neutrophilia and calf 2 had neutrophilic pleocytosis in CSF. Bacteria were not isolated from CSF, from the surgical site or during necropsy. Calf 2 improved neurologically and had a good long‐term outcome. Conclusion— Good outcome in a calf with SEA was obtained after adequate surgical decompression and antibiotic administration. Clinical Relevance— SEA should be included in the list of possible causes of fever, apparent spinal pain, and signs of myelopathy in calves. 相似文献
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DAVIDE D. ZANI DONATELLA DE ZANI NICOLA MORANDI MARIANNA BIGGI ANGELO G. BELLOLI PIETRO RICCABONI MARCO RONDENA MAURO DI GIANCAMILLO DAVIDE PRAVETTONI 《Veterinary radiology & ultrasound》2010,51(1):57-60
The features of a calf with a split cord malformation are described. Clinically, there was severe cervicothoracic kyphoscoliosis and an interscapular dermal sinus associated with cerebrospinal fluid drainage. Using magnetic resonance imaging, complete duplication of the spinal cord at the cervical intumescence was detected. There was associated syringohydromyelia, multiple cervicothoracic vertebral malformations resulting in kyphoscoliosis and rachischisis, herniation of the cerebellar vermis, meningoencephalocele, and calvarial defects. 相似文献
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SILKE HECHT INDIA F. LANE GREGORY B. DANIEL FEDERICA MORANDI DOROTHY E. SHARP 《Veterinary radiology & ultrasound》2008,49(6):589-594
The purpose of this study was to develop a protocol for diuretic renal scintigraphy (renography) in cats and describe normal findings. 99mTc‐DTPA renal scintigraphy was performed twice in 10 healthy cats. Furosemide or saline were injected 4.5 min after radiopharmaceutical administration for the diuretic or control scan, respectively. A dynamic acquisition was performed for 8 min. The following parameters were evaluated: (1) global and individual glomerular filtration rate (GFR); (2) shape of the time–activity curve (TAC); (3) time of peak (TOP); (4) individual kidney excretion half‐time (T1/2) of the radiopharmaceutical; (5) percentage of maximum activity measured at the end of the study. Global GFR in the control studies (2.79±0.83 ml/min/kg, mean±SD) did not differ significantly from the diuretic scans (2.34±0.51 ml/min/kg). The shape of most (16/20) TAC of diuretic renograms was similar to those of control renograms. The TOP of the diuretic renogram curves was 3.06±0.58 min, and did not differ from that of the control scans (3.01±0.61 min). T1/2 of the diuretic renograms was significantly shorter (5.15±0.83 min) than that of the control renograms (6.31±1.50 min). A significantly lower percentage of maximum activity was present at the end of the study in diuretic renograms (median: 47.25%; range: 33.60–59.60%) compared with control renograms (63.40%; 30.00–69.40%). Diuretic renal scintigraphy is a noninvasive and fast procedure to perform in cats. The applicability of this technique needs to be investigated in patients with significantly impaired renal function and obstructive uropathies. 相似文献