排序方式： 共有6条查询结果，搜索用时 15 毫秒
1
1.
ALISON P. BOOK JANEAN FIDEL TAMARA WILLS JEFFREY BRYAN RANCE SELLON JOHN MATTOON 《Veterinary radiology & ultrasound》2011,52(5):548-554
Cytologic sampling of the ultrasonographically normal spleen and liver is not implemented routinely in the clinical staging of canine cutaneous mast cell tumors and normal ultrasound findings are often accepted as sufficient evidence for ruling out splenic or liver metastasis. Our objective was to define the specificity and sensitivity of ultrasound findings for diagnosis of mast cell infiltration when verified with cytologic evaluation, and to define the prognostic role of cytologic evaluation of liver and splenic aspirates. Dogs with a diagnosis of clinically aggressive grade II, or grade III mast cell tumor treated with a combination vinblastine/CCNU chemotherapy protocol, were selected retrospectively based on availability of cytologic evaluation of spleen plus or minus liver for staging. Out of 19 dogs, 10 dogs had a grade II tumor and nine a grade III tumor. Seven dogs had mast cell infiltration of the spleen, liver, or both. The sensitivity of ultrasound for detecting mast cell infiltration was 43% for the spleen and 0% for the liver. Dogs with positive cytologic evidence of mast cell infiltration to spleen, liver, or both had significantly shorter survival (100 vs. 291 days) than dogs without evidence of mast cell infiltration (P<0.0001). Routine splenic aspiration should be performed regardless of ultrasonographic appearance in dogs with a clinically aggressive mast cell tumor. 相似文献
2.
JANEAN L. FIDEL RANCE K. SELLON ROBERT K. HOUSTON BETSY A. WHEELER 《Veterinary radiology & ultrasound》2007,48(5):482-485
Nine cats with oral squamous cell carcinoma were treated with an accelerated radiation protocol (14 fractions of 3.5 Gy in 9 days). Radiation was administered twice daily with a 6hour break between treatments. Median overall survival was 86 +/- 110 days. Median survival for cats with a partial response (n=6) was 60 +/- 7 days, while median survival for cats with a complete response (n=3) was 298 +/- 187 days (P = 0.0639). The accelerated protocol was well tolerated and toxicity in the early and late period was manageable in all cats. Further modification of the protocol is warranted to extend survival. 相似文献
3.
IGNACIO A. GÓMEZ DE SEGURA DVM PhD RAFAEL DE ROSSI DVM MS MARTIN SANTOS DVM JAVIER LÓPEZ SAN-ROMAN DVM PhD FRANCISCO J. TENDILLO DVM PhD Diplomate ECVA 《Veterinary surgery : VS》1998,27(4):384-391
Objective—To determine the analgesic, sedative, and cardiopulmonary effects of epidural ketamine in the horse. Animal Population—Six healthy horses (three males and three females) weighing between 350 and 450 kg. Methods—Three doses of ketamine were selected (0.5, 1, and 2 mg/kg). Two months before the beginning of experiments, the carotid artery was exteriorized, and 1 week before experiments began, an epidural catheter was placed percutaneously in all animals with the tip located 12 cm cranially in the midsacrum. One week later, either saline (control) or one of three doses of ketamine was injected epidurally. Each animal received each ketamine dose and saline in random order at 1-week intervals. Ketamine was diluted in saline 0.9% before the experiment, and the volume used was adjusted to horse size and correlated to clinically used volumes. All the animals received a standard noxious stimulus consisting of needle insertion into the skin and deep muscle using a 3-point scale for scoring the response. A second scale was used to score the degree of sedation. The response to a noxious stimulus, the degree of sedation, and arterial blood pressure were assessed at previously determined intervals: before drug and 2, 5, 10, and 15 minutes and every 15 minutes to 210 minutes after ketamine or saline administration. Arterial blood samples were drawn for blood gas analysis before drug and at 15, 30, 60, and 90 minutes. Results—All the tested doses of ketamine were effective in producing analgesia of the tail, perineum, and upper hindlimb. Total tail and perineal analgesia times were similar depending on dosage (30 minutes for 0.5 and 1.0 mg/kg and 75 minutes for 2.0 mg/kg). A sedative effect of ketamine was also observed in a dose-response manner with a peak effect between 15 and 30 minutes postadministration. No cardiopulmonary effects were observed with any dose of ketamine. Conclusions—Results indicate that epidurally administered ketamine in the horse produces local spinal and central nervous system effects with analgesia and sedation but minimal cardiopulmonary effects. Clinical Relevance—Further studies are required to determine whether the analgesia is sufficient for surgery. 相似文献
4.
DORA GUTIÉRREZ SANDRA MENDOZA VALENTINA SERRANO MOUSTAPHA BAH RICARDO PELZ PATRICIA BALDERAS FIDEL LEÓN 《Weed Biology and Management》2008,8(4):291-296
Many wild weeds are used in Mexico as fodder. Due to their economic value, this investigation was undertaken to determine the chemical composition of 14 species. The mineral, crude protein, fiber, and total phenolic content, as well as the antioxidant activity, was determined. There was a significant variation in the mineral content among the 14 weeds, which all had calcium and potassium as the predominant elements. According to the results, some of the weeds might represent possible mineral deficiency sources, making the supplementation of certain minerals advisable. Although five of the species contained a low concentration of magnesium, the overall mineral ratios of the forage weeds were at safe levels, preventing grazing animals suffering from grass tetany, in contrast to the excessive calcium : phosphorus ratios that can affect their normal growth and bone development. The crude fiber and protein content in most of the weeds fell into the recommended range for the maintenance of cattle. The phenolic content of the studied weed extracts was higher than that reported for several Mediterranean forage species. These phenolic profiles correlate well with the radical scavenging activities of the extracts. 相似文献
5.
SIMONA MAYER-STANKEOVÁ JANEAN FIDEL MELANIE C. WERGIN BEAT HAUSER REA SUMOVÁ GUDRUN GOITEIN EROS PEDRONI ANTHONY J. LOMAX UWE SCHNEIDER HANS BLATTMANN BARBARA KASER-HOTZ 《Veterinary radiology & ultrasound》2009,50(3):314-318
Thirty dogs with spontaneous tumors were irradiated with proton therapy using a novel spot scanning technique to evaluate the safety and efficacy of the system, and to study the acute and late radiation reactions. Nasal tumors, soft tissue sarcomas, and miscellaneous tumors of the head were treated with a median total dose of 52.5 Gy given in 3.5 Gy fractions. Acute effects, late effects, tumor response, and outcome were analyzed. No unexpected radiation reactions were seen, however two dogs did develop in-field osteosarcoma, and one dog developed in-field bone necrosis. Complete response to therapy was seen in 40% (12/30), partial response in 47% (14/30), and no response in 13% (4/30). Median survival for all dogs was 385 days (range of 14–4583 days). Dogs with nasal cavity tumors had a median survival of 385 days (range of 131–1851 days) and dogs with soft tissue sarcomas had a median survival time of 612 days (range of 65–4588 days). Treatment outcome was similar to historical controls. This new proton spot scanning technique proved to be safe and reliable. 相似文献
6.
MÁRIO M. D. GINJA ANTÓNIO J. FERREIRA SANDRA S. JESUS PEDRO MELO-PINTO JOSÉ BULAS-CRUZ MARIA A. ORDEN FIDEL SAN-ROMAN MARIA P. LLORENS-PENA JOSÉ M. GONZALO-ORDEN 《Veterinary radiology & ultrasound》2009,50(2):135-143
The purpose of the study was to use two palpation methods (Bardens and Ortolani), a radiographic distraction view, three computed tomography (CT) measurements (dorsolateral subluxation score, the lateral center-edge angle, and acetabular ventroversion angle) and two magnetic resonance (MR) imaging hip studies (synovial fluid and acetabular depth indices) in the early monitoring of hip morphology and laxity in 7–9 week old puppies; and in a follow-up study to compare their accuracy in predicting later hip laxity and dysplasia. The MR imaging study was performed with the dog in dorsal recumbency and the CT study with the animal in a weight-bearing position. There was no association between clinical laxity with later hip laxity or dysplasia. The dorsolateral subluxation score and the lateral center-edge angle were characterized by a weak negative correlation with later radiographic passive hip laxity (−0.26< r <−0.38, P <0.05) but its association with hip dysplasia was not significant. There was an association between early radiographic passive hip laxity and synovial fluid index with later passive hip laxity (0.41< r <0.55, P <0.05) and this was significantly different in dysplastic vs. nondysplastic hips ( P <0.05). There was no association between the remaining variables and later hip laxity or dysplasia. The overlapping ranges of early passive hip laxity and synovial fluid index for hip dysplasia grades and the moderate correlations with the later passive hip laxity make the results of these variables unreliable for use in predicting hip laxity and dysplasia susceptibility. 相似文献
1