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GWENDOLYN L. CARROLL MS DVM Diplomate ACVA R. NEIL HOOPER DVM Diplomate ACVS MARGARET R. SLATER DVM PhD SANDEE M. HARTSFIELD DVM MS Diplomate ACVA NORA S. MATTHEWS DVM Diplomate ACVA 《Veterinary surgery : VS》1998,27(1):75-82
Objective—To determine the safety and efficacy of propofol, after detomidine-butorphanol premedication, for induction and anesthetic maintenance for carotid artery translocation and castration or ovariectomy in goats. Study Design—Case series. Animals—Nine 4-month-old Spanish goats (17.1 ± 2.6 kg) were used to evaluate propofol anesthesia for carotid artery translocation and castration or ovariectomy. Methods—Goats were premedicated with detomidine (10 μg/kg intramuscularly [IM]) and butorphanol (0.1 mg/kg IM) and induced with an initial bolus of propofol (3 to 4 mg/kg intravenously [IV]). If necessary for intubation, additional propofol was given in 5-mg (IV) increments. Propofol infusion (0.3 mg/kg/min IV) was used to maintain anesthesia, and oxygen was insufflated (5 L/min). The infusion rate was adjusted to maintain an acceptable anesthetic plane as determined by movement, muscle relaxation, ocular signs, response to surgery, and cardiopulmonary responses. Systolic (SAP), mean (MAP) and diastolic (DAP) arterial pressures, heart rate (HR), ECG, respiratory rate (RR), Spo2, and rectal temperature (T) were recorded every 5 minutes postinduction; arterial blood gas samples were collected every 15 minutes. Normally distributed data are represented as mean ± SD; other data are medians (range). Results—Propofol (4.3 ± 0.9 mg/kg IV) produced smooth, rapid (15.2 ± 6 sec) sternal recumbency. Propofol infusion (0.52 ± 0.11 mg/kg/min IV) maintained anesthesia. Mean anesthesia time was 83 ± 15 minutes. Muscle relaxation was good; eye signs indicated surgical anesthesia; two goats moved before surgery began; one goat moved twice during laparotomy. Means are reported over the course of the data collection period. Means during the anesthesia for pHa (arterial PH), Paco2, Pao2, HCO3, and BE (base excess) ranged from 7.233 ± 0.067 to 7.319 ± 0.026, 54.1 ± 4.6 to 65.3 ± 12.0 mm Hg, 133.1 ± 45.4 to 183.8 ± 75.1 mm Hg, 26.9 ± 2.6 to 28.2 ± 2.1 mEq/L, and -0.8 ± 2.9 to 1.4 ± 2.2 mEq/L. Means over time for MAP were 53 ± 12 to 85 ± 21 mm Hg. Mean HR varied over time from 81 ± 6 to 91 ± 11 beats/minute; mean RR, from 9 ± 8 to 15 ± 5 breaths/minute; Spo2, from 97 ± 3% to 98 ± 3%; mean T, from 36.0 ± 0.6±C to 39.1 ± 0.7±C. Over time, Spo2 and Sao2 did not change significantly; HR, RR, T, and Paco2 decreased significantly; SAP, DAP, MAP, pHa, Pao2, and BE increased significantly. HCO3 concentrations increased significantly, peaking at 45 minutes. Recoveries were smooth and rapid; the time from the end of propofol infusion to extubation was 7.3 ± 3 minutes, to sternal was 9.2 ± 5 minutes, and to standing was 17.7 ± 4 minutes. Median number of attempts to stand was two (range of one to four). Postoperative pain was mild to moderate. Conclusions—Detomidine-butorphanol-propofol provided good anesthesia for carotid artery translocation and neutering in goats. Clinical Relevance—Detomidine-butorphanol-propofol anesthesia with oxygen insufflation may be safely used for surgical intervention in healthy goats. 相似文献
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The effect of herbage allowance on intake and performance of ewes suckling twin lambs 总被引：2，自引：0，他引：2
The effect of herbage allowance on the herbage intake and performance of ewes and their twin lambs at pasture was investigated. Daily herbage allowances of 40,80.120 and 160 g organic matter (OM) kg-1 ewe live weight, based on herbage mass measured to ground level, were offered during the first 12 weeks of lactation.
The sheep were grazed rotationally around four paddocks of a perennial ryegrass pasture for 7-day periods and herbage mass, extended tiller length and digestibility of the herbage consumed by the animals were estimated. Herbage intake by the ewes was estimated during weeks two to twelve and live weights were recorded weekly: during the last two weeks of the experiment grazing behaviour of one ewe on each treatment was recorded continuously.
Herbage intakes by the ewes (164, 1–81, 2–42 and 268 ± 0153 kg d-1 ) and live weight gains of the lambs (202, 245, 274 and 300 ± 7–3 g d-1 ) increased with increasing herbage allowances. Herbage intakes by the ewes and growth rates of their lambs increased up to a herbage allowance which was over five times the amount of herbage eaten by the ewes.
As the animals reduced herbage mass and sward height, biting rates by the ewes during grazing increased by 4 (± 0·08) bites min-1 cm-1 and masticating rates decreased. Mastications reached a maximum of 90 (± 3·5) min-1 at a sward surface height of 9 cm. 相似文献
The sheep were grazed rotationally around four paddocks of a perennial ryegrass pasture for 7-day periods and herbage mass, extended tiller length and digestibility of the herbage consumed by the animals were estimated. Herbage intake by the ewes was estimated during weeks two to twelve and live weights were recorded weekly: during the last two weeks of the experiment grazing behaviour of one ewe on each treatment was recorded continuously.
Herbage intakes by the ewes (164, 1–81, 2–42 and 268 ± 0153 kg d
As the animals reduced herbage mass and sward height, biting rates by the ewes during grazing increased by 4 (± 0·08) bites min
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Exogenous paraoxonase‐1 during oocyte maturation improves bovine embryo development in vitro 
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下载免费PDF全文 JAA Rincón EM Madeira FT Campos B Mion JF Silva VA Absalón‐Medina WR Butler MN Corrêa LMC Pegoraro A Schneider 《Reproduction in domestic animals》2016,51(5):827-830
Paraoxonase‐1 (PON1) is an enzyme found in serum and follicular fluid that protects cell membrane and circulating lipids against oxidative damage. The aims of this study were to measure the direct effects of recombinant PON1 (rPON1) on bovine oocyte maturation at the molecular level (gene expression) and to measure the carry‐over effects of PON1 on pre‐implantation embryo development in vitro. COCs were submitted to IVM with the addition of 0.0, 0.02, 0.04 and 0.08 mg ml?1 of rPON1, corresponding to an average PON1 arylesterase enzyme activity of 2.2 ± 0.4, 15.5 ± 1.5, 30.2 ± 3.0 and 57.9 ± 5.0 U ml?1, respectively. The results indicated that addition of rPON1 during IVM improved embryo development in a dose‐dependent manner as D7 embryo development was 22.2%, 29.4%, 32.2% and 37.0% for the treatment groups, respectively (p = 0.02). In conclusion, addition of PON1 enzyme during IVM exerted dose‐related positive effects on embryo development rates to blastocysts. 相似文献