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The severity of the erosive and ulcerative lesions of the squamous gastric mucosa in 10 standardbred racehorses in training was classified according to a standard scoring system. Each horse was then treated orally for 30 days with 50 g/100 kg bodyweight daily of a pectin-lecithin complex mixed into the feed. At the end of the period of treatment, the gastric lesions were re-evaluated gastroscopically and the scores were compared with those assigned at the previous evaluation. In three of the horses the gastric ulcerations had healed completely, and in six others the lesions had improved significantly. 相似文献
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Veronica Redaelli Domenico Bergero Enrica Zucca Francesco Ferrucci Leonardo Nanni Costa Lorenzo Crosta Fabio Luzi 《Journal of Equine Veterinary Science》2014
This review of the use of thermographic technique in equines introduces the principles upon which infrared radiation and thermoregulatory physiology are based and describes the instrumentation used and its practical use. The advantage of this imaging technique is that it is a noninvasive thermographic examination, both from an operational (the animal and the operator) and health (no penetrating radiation is used) standpoint. Advantages and disadvantages of this technique, equine applications, and physiological assessments are discussed. 相似文献
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Diana Binanti Giovanni Stancari Eleonora Fantinato Enrica Zucca Davide Danilo Zani Giuseppe Sironi Francesco Ferrucci Pietro Riccaboni 《Journal of Equine Veterinary Science》2013
A case of pulmonary carcinoma in a 23-year-old Quarterhorse mare is described. On physical examination, depression, poor body condition, tachypnea, bilateral serosanguineous nasal discharge and a wide area of reduced breath sounds in association with the right hemithorax were detected. Laboratory evaluation showed leukocytosis with neutrophilia and lymphopenia, hyperfibrinogenemia, hyperprotidemia, hypoalbuminemia, increased beta 2 and gamma globulin fractions, hypoxemia, and normocapnia. Radiography and thoracic ultrasonography revealed a large rounded mass extending from the 9th to the 14th right intercostal space, where neither bronchial nor vascular structures were detectable. Endoscopy showed a large amount of serosanguineous fluid within the tracheal lumen and a mass of reddish soft tissue completely obliterating the right caudal lobar bronchus. Histopathology of the endobronchial mass and of the transthoracic ultrasound-guided biopsy samples was consistent with a primary pulmonary epithelial tumor. Due to worsening of the clinical condition, the mare was euthanized. Postmortem examination confirmed the presence of a large 30-cm mass located in the right caudal pulmonary lobe, characterized by epithelial cells arranged in papillary projections and alveolar structures, findings consistent with bronchioloalveolar carcinoma. 相似文献
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Antioxidant activity of hyaluronic acid investigated by means of chemiluminescence of equine neutrophil bursts and electron paramagnetic resonance spectroscopy 
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下载免费PDF全文 P. C. Braga M. Dal Sasso N. Lattuada V. Greco V. Sibilia E. Zucca L. Stucchi E. Ferro F. Ferrucci 《Journal of veterinary pharmacology and therapeutics》2015,38(1):48-54
Activated neutrophils (PMNs), the ROS/RNS released by PMNs and the derived inflammatory processes are involved in the pathogenesis and progression of human inflammatory airway diseases. Similar diseases are also present in horses which suffer from recurrent airway obstruction (RAO), exercise‐induced pulmonary haemorrhage (EIPH) and inflammatory airway diseases (IAD). Hyaluronic acid (HA) plays numerous roles in modulating inflammatory processes. The aim of this study was to examine whether a preparation of HA (MW 900 000 Da) interferes with ROS/RNS during the course of equine PMN respiratory bursts, and to establish the lowest concentration at which it still has antioxidant activity by means of luminol‐amplified chemiluminescence (LACL). Electron paramagnetic resonance (EPR) spectroscopy was also used to investigate the direct antiradical activity of HA. The hydroxyl radical was significantly scavenged in a concentration‐dependent manner at HA concentrations ranging from 2.5 to 0.16 mg/mL. Superoxide anion, Tempol radical and the ABTS? + were significantly inhibited at concentrations ranging from 2.5 to 0.62 mg/mL. The LACL of stimulated equine neutrophils showed that HA induced a statistically significant concentration–effect reduction from 5 mg/mL to 1.25 mg/mL. These findings were confirmed also when l ‐Arg was added to investigate the inhibition of the resulting peroxynitrite anion. Our findings indicate that, in addition to the human use, HA can also be used to antagonize the oxidative stress generated by free radicals in horses peripheral blood mononuclear cells (PBMCs). In order to achieve therapeutic concentrations, a direct aerosol administration to horses with horse respiratory diseases can be considered, as this route of application is also recommended in human medicine. 相似文献
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F. Ferrucci E. Zucca C. Croci V. Di Fabio P. A. Martino E. Ferro 《Equine Veterinary Education》2008,20(10):526-531
Seventeen racehorses were referred with a history of poor performance, recurrent fever, coughing and/or nasal discharge. All patients underwent a thorough diagnostic procedure, including physical examination, complete blood count, plasma fibrinogen estimation, arterial blood gas analysis, thoracic radiology and ultrasonography, endoscopy, tracheal aspiration with cytological and cultural evaluation, including sensitivity test. According to these procedures, bacterial pneumonia was diagnosed in 14 horses and bacterial pleuropneumonia in 3 horses. Streptococcus spp. were isolated in 11 cases (61.2%), Rhodococcus equi in 3 cases (16.6%), Klebsiella pneumoniae in 3 cases (16.6%) and Pseudomonas aeruginosa in one case (5.6%). 相似文献
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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity 总被引：2，自引：0，他引：2
Frayling TM Timpson NJ Weedon MN Zeggini E Freathy RM Lindgren CM Perry JR Elliott KS Lango H Rayner NW Shields B Harries LW Barrett JC Ellard S Groves CJ Knight B Patch AM Ness AR Ebrahim S Lawlor DA Ring SM Ben-Shlomo Y Jarvelin MR Sovio U Bennett AJ Melzer D Ferrucci L Loos RJ Barroso I Wareham NJ Karpe F Owen KR Cardon LR Walker M Hitman GA Palmer CN Doney AS Morris AD Smith GD Hattersley AT McCarthy MI 《Science (New York, N.Y.)》2007,316(5826):889-894
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass. 相似文献
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Ribeiro AP Silva ML Araújo RL Ferrucci DL Mineo T Thiesen R Bandarra MB Laus JL 《Veterinary ophthalmology》2012,15(3):153-163
Purpose To study the effects of topical administration of 1% morphine on corneal analgesia in rabbits submitted to lamellar keratectomy and to assess the expression of matrix metalloproteinase‐1, metalloproteinase‐2, metalloproteinase‐9 (MMPs), type IV collagen, and interleukin‐10 (IL‐10) during the treatment. Methods Morphine group (MG) received 50 μL of topical 1% morphine four times daily, while the control group received saline instead. Corneal touch threshold (CTT) and the wound area were assessed until corneal healing. Corneal samples were processed for routine histology, immunohistochemistry, zymography, and ELISA. Results Following keratectomy, CTT increased significantly from 6 to 96 h time points. Mean corneal re‐epithelization rate and scores of leukocyte infiltration did not differ significantly between treatment groups. Immunolabeling pattern for MMP‐1, MMP‐9, and type IV collagen was similar in both treatment groups. In the MG, zymography indicated significantly higher levels of active MMP‐2 on days 6 and 12; and in the latent MMP‐9, on days 3 and 6, and in the active MMP‐9, on day 6. Latent MMP‐2 and MMP‐9, and active MMP‐9 decreased to values close to those of healthy corneas on day 12, but levels of active MMP‐2 remained significantly elevated in the MG. IL‐10 levels measured on days 1–6 were reduced as compared to those of healthy corneal tissue and returned to levels close to those of healthy corneas on day 12. Conclusion Topical morphine promoted corneal analgesia for up to 4 days and did not delay corneal re‐epithelization. The re‐establishment of MMPs and IL‐10 to levels close to baseline values at the end of the study and the expression of type IV collagen in both groups reinforce that, with caution, 1% morphine can be used after lamellar keratectomy in rabbits. 相似文献
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Conservative treatment of acquired oesophageal strictures by endoscopic‐guided balloon dilation in two horses 下载免费PDF全文
下载免费PDF全文 L. Stucchi E. Zucca G. Stancari B. Conturba S. Roncon E. Ferro M. Gualtieri F. Ferrucci 《Equine Veterinary Education》2017,29(5):259-265
Oesophageal stricture is an uncommon condition in horses that results in an obstructive syndrome with regurgitation of food and possible aspiration pneumonia. Currently, in both human and small animal practice, one of the preferred treatment options for oesophageal strictures consists of pneumatic or hydrostatic balloon dilation. The aim of this article is to report 2 cases of severe oesophageal stricture in the horse, successfully treated with endoscopic‐guided hydrostatic balloon dilation. 相似文献