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Adetola R Ajadi DVM MVSC Timothy A Olusa DVM MVSC Olusiji F Smith† BSc MSc PhD Eyitayo S Ajibola‡ DVM MSc Olusola E Adeleye‡ DVM MSc Olubukola T Adenubi‡ DVM MSc & Folashade A Makinde§ DVM 《Veterinary anaesthesia and analgesia》2009,36(6):562-566
ObjectiveTo evaluate the influence of premedication with tramadol on xylazine–ketamine anaesthesia in young pigs.Study designProspective, randomized, blinded cross-over study.AnimalsTen young Niger hybrid pigs: mean weight 6.1 ± 0.6 kg.MethodsPigs were anaesthetized twice. Xylazine (2.5 mg kg?1), ketamine (25 mg kg?1) and atropine (0.04 mg kg?1) were administered by intramuscular (IM) injection, 5 minutes after either tramadol (5 mg kg?1)) (treatment XKT) or saline (treatment XKS). Time to loss of righting reflex (TLRR), duration of antinociception, duration of recumbency (DR) and recovery times (RCT) were recorded. Quality of induction of anaesthesia including ease of endotracheal intubation was assessed using a subjective ordinal rating score of 1 (worst) to 4 (best). Heart, pulse and respiratory rates, arterial oxygen saturations and rectal temperatures were determined over 60 minutes. Antinociception was assessed by the pigs’ response to artery forceps applied at the interdigital space. Data were compared with Student's t-test, Mann–Whitney's test or analysis of variance (anova) for repeated measures as appropriate and are presented as mean ± standard deviation.ResultsThe quality of anaesthetic induction was significantly better and duration of antinociception significantly longer (p < 0.05) in treatment XKT (3.1 ± 0.7 score; 43.7 ± 15.5 minutes) than in treatment XKS (2.8 ± 0.6 score; 32.0 ± 13.3 minutes). TLRR, DR and RCT did not differ significantly (p > 0.05) between treatment XKT (2.1 ± 0.8, 65.8 ± 17.0 and 13.2 ± 6.7 minutes) and treatment XKS (2.1 ± 1.3, 58.0 ± 14.8 and 10.3 ± 5.6 minutes). Physiological measurements did not differ between the treatments.Conclusion and clinical relevanceTramadol improved the quality of anaesthetic induction and increased the duration of antinociception in xylazine–ketamine anaesthetized young pigs without increasing duration of anaesthesia, nor causing additional depression of the physiological parameters measured. 相似文献
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Folashade Olaifa Joseph Olusegun Ayo Suleiman Folorunsho Ambali Peter Ibrahim Rekwot Ndazo Salka Minka 《Tropical animal health and production》2013,45(2):473-477
The aim of the experiment was to evaluate the effect of 4-h load carrying (packing) on donkeys administered with ascorbic acid (AA) during the harmattan season. Six donkeys administered orally with ascorbic acid (200 mg/kg) and subjected to packing served as experimental animals, while six others given only distilled water served as control animals. The rectal temperature (RT) of each donkey and dry-bulb temperature (DBT) and relative humidity (RH) of the research pen were recorded at 0600 hours pre-packing; while post-packing, the values were obtained at 1430, 1600 and 1800 hours. The DBT values (ranges) recorded before, during and after packing were 13.7?±?1.3 °C (11–15 °C), 28.4?±?1.0 °C (22.7–30.3 °C) and 30.6?±?3.0 °C (19.8–45 °C), respectively. The highest temperature–humidity index (THI) of 83.4?±?6.9 was obtained at 1430 hours after packing, and the value decreased to 64.2?±?5.8 at 1800 hours. The thermal environmental conditions were outside the thermoneutral zone for the donkeys. The RT values recorded immediately after packing did not differ (P?>?0.05) in experimental and control donkeys; but at 1600 and 1800 hours, values obtained in control donkeys (38.48?±?0.12 and 38.12?±?0.12 °C, respectively) were significantly higher (P?<?0.05) than those recorded in experimental donkeys (38.16?±?0.14 and 37.85?±?0.14 °C, respectively). In conclusion, administration of ascorbic acid reduced the rise in RT due to packing and may be of value in the amelioration of adverse effects of heat stress associated with work in donkeys. 相似文献
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Folashade OLAIFA Joseph Olusegun AYO Suleiman Folorunsho AMBALI Peter Ibrahim REKWOT 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(2):133-138
Experiments were performed to investigate the effect of ascorbic acid (AA) in reducing hemato-biochemical changes in pack donkeys during the cold-dry (harmattan) season. Six experimental donkeys administered orally AA (200 mg/kg) and six control donkeys not administered ascorbic acid were subjected to packing. Blood samples were collected from all donkeys for hematological and biochemical analyses. In the control donkeys, packed cell volume (PCV), erythrocyte count and hemoglobin concentration (Hb) decreased significantly (P<0.05) at the end of packing. In the experimental donkeys, there was no significant difference between the pre- and post-packing values of PCV, erythrocyte count and Hb. In the control donkeys, the neutrophil and neutrophil:lymphocyte ratio increased significantly (P<0.05) post packing, but in the experimental donkeys, the pre- and post-packing values were not significantly different. The eosinophil count
increased significantly (P<0.05) in experimental and control donkeys post packing. In conclusion, packing exerted significant adverse effects on the hematological parameters ameliorated by AA administration. AA may modulate neutrophilia and induce a considerable alteration of erythroid markers in donkeys subjected to packing during the harmattan season. 相似文献
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Olaifa Folashade Helen Ayo Joseph Olusegun Aluwong Tangang Rekwot Peter Ibrahim Zakari Friday Ocheja 《Tropical animal health and production》2019,51(2):389-394
Tropical Animal Health and Production - The aim of the study was to determine some ergonomic parameters of donkeys administered with Pycnogenol® (PYC) and subjected to packing during the... 相似文献
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