Pilot study of the effect of acemannan in cats infected with feline immunodeficiency virus.   总被引：7，自引：0，他引：7  

K M Yates  L J Rosenberg  C K Harris  D C Bronstad  G K King  G A Biehle  B Walker  C R Ford  J E Hall  I R Tizard 《Veterinary immunology and immunopathology》1992,35(1-2):177-189

Acemannan, a complex carbohydrate shown to stimulate interleukin-1, tumor necrosis factor alpha and prostaglandin E2 production by macrophages, has also demonstrated antiviral activity in vitro against human immunodeficiency virus, Newcastle disease virus and influenza virus. A pilot study was undertaken to determine acemannan's effect in 49 feline immunodeficiency virus (FIV) infected cats with clinical signs of disease (Stage 3, 4 or 5), 23 of which had severe lymphopenia. Cats received acemannan either by intravenous (Group 1) or subcutaneous (Group 2) injection once weekly for 12 weeks, or by daily oral (Group 3) administration for 12 weeks. Upon entry into the study, cats were randomly assigned to one of the three groups. Laboratory analyses were performed at the beginning of the study and at Weeks 6 and 12. Cats were allowed to continue with a predetermined maintenance regimen of acemannan after completing the 12-week study. Thirteen cats died during the course of treatment. Upon necropsy, the most frequent histopathologic findings were neoplastic, kidney and pancreatic disease. Friedman's two-way ANOVA test showed no significant differences in efficacy among groups administered acemannan by the different routes. Therefore, groups were combined and a signed-ranks test was used to determine changes over time. A significant increase was seen in lymphocyte counts (P < 0.001). Neutrophil counts decreased significantly (P = 0.007), as did incidence of sepsis (P = 0.008). When cats entering with lymphopenia were analyzed separately, a much greater increase in lymphocyte counts was noted (235%) compared with non-lymphopenic cats (42%). A survival rate of 75% was found for all three groups. Thirty-six of 49 animals are alive 5-19 months post-entry. These results suggest that acemannan therapy may be of significant benefit in FIV-infected cats exhibiting clinical signs of disease.  相似文献   

The duration of lot-feeding of sheep before sea transport     

RT NORRIS  RB RICHARDS  GJ NORMAN 《Australian veterinary journal》1992,69(1):8-10

Adult wethers (n = 750) were lot-fed for 13 days, 8 days or 3 days before a simulated voyage lasting 18 days to examine whether the period of lot-feeding affected the proportion of sheep that ate pelleted feed and their body weight change during simulated shipping. There was no significant difference in the proportion of non-feeders between treatment groups on days 7 and 14 of the voyage. Body weights were not significantly different between the treatment groups on days 14 and 18 of the voyage. Overall body weight loss, from the farm to the end of simulated shipping, was 4.08 kg (+/- 0.28, s.e.m.), 4.58 kg (+/- 0.28) and 4.51 kg (+/- 0.28) in sheep lot-fed for 13 days, 8 days and 3 days, respectively, and was not significantly different between treatments. It was concluded that lot-feeding for 13 days conferred no advantage in body weight or numbers of non-feeders compared with shorter periods in this study.  相似文献   

The effect of moxidectin against benzimidazole- and levamisole-resistant nematodes of sheep in Western Australia     

RB BESIER  J. LYON  PJ KIERAN 《Australian veterinary journal》1993,70(11):422-423

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Iodine content of commercially-prepared cat foods     

Johnson LA  Ford HC  Tarttelin MF  Feek CM 《New Zealand veterinary journal》1992,40(1):18-20

Twenty-eight varieties of commercially-available cat food (23 canned, 5 dried) were analysed for iodine. The iodine concentration varied from less than 0.37 micromol/kg to 41.8 pmol/kg, wet weight (less than 1.48 micromol/kg to 167 micromol/kg, dry weight). Excessive or insufficient iodine intake or wide swings in iodine intake over prolonged periods may contribute to thyroid disorders in cats.  相似文献   

Equine rhinopneumonitis vaccine: immunogenicity and safety in adult horses, including pregnant mares.     

C W Purdy  S J Ford  R C Porter 《American journal of veterinary research》1978,39(3):377-383

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Equine rhinopneumonitis vaccine: immunogenicity and safety in foals.     

C W Purdy  R C Porter  S J Ford 《American journal of veterinary research》1978,39(5):745-752

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Bovine ovarian and pituitary responses to PMS and GnRH administered during metestrus.     

S P Ford  F Stormshak 《Journal of animal science》1978,46(6):1701-1706

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Right forelimb lameness in an 8-year-old Rottweiler     

D TYRRELL  C BECK  C LENGHAUS  RB LAVELLE 《Australian veterinary journal》2005,83(3):140-148

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Antifungals and their use in veterinary ophthalmology.     

Marnie M Ford 《Veterinary Clinics of North America: Small Animal Practice》2004,34(3):669-691

Many variables affect the outcome of keratomycosis and systemic fungal infections in animals. These include pathogenicity of the fungal organism(toxins, trophisms, and evasion of host response); previous treatment with topical or systemic corticosteroids, which can have a dramatic negative impact on host defense mechanisms: concurrent systemic illness or immunocompromise: severity/extent of infection; and degree of pain (ie,increased reflex tearing dilutes topical medication) [14]. Experimental work suggests that antibiotics may occasionally exacerbate fungal infections [142],and some researchers advocate that concurrent antibiotic therapy is contraindicated in horses with yeast infections and septate fungal infections unless bacterial infection is also suspected [14]. Nevertheless, given that normal conjunctival flora often include bacteria and fungi and because care of keratomycoses often includes mixed bacterial and fungal infections, the possible dynamics (natural influences and local competition) between ocular surface microorganisms merit further investigation. There are many unanswered questions regarding the accuracy of in vitro susceptibilities and corneal concentration capabilities for antifungal topical medications [14].Inherent host resistance or other immune interactions between the patient and fungus are perhaps the most important determinants of the outcome but are currently difficult to measure or assess except by subjective clinical observation [14].  相似文献   

The Response to Epsom Salt Sprays of Mature Apple Trees of Three Varieties on Two Contrasting Rootstocks     

Elsie M. Ford 《The Journal of Horticultural Science and Biotechnology》2013,88(4):505-517

Mature trees of Beauty of Bath, Tydeman’s Late Orange and Laxton’s Superb on M.VII rootstock, growing under commercial-type conditions, were severely deficient in magnesium as shown by leaf analysis and typical symptoms. Five sprays yearly of 2% Epsom salt (MgSO₄.7H₂ O) raised the concentration of magnesium in the leaves and largely eliminated symptoms: the concentrations of calcium and, to a lesser extent, of potassium in leaves were reduced. Over six years, there was little effect of Epsom salt on growth as measured, but crop weight was increased by 19–39% according to variety: this was largely, but not entirely, due to increase in fruit set. The proportion of fruit that dropped was decreased for Beauty of Bath and for Tydeman’s Late Orange sprayed with Epsom salt and the weight per 100 fruits of the late varieties Tydeman’s Late Orange and Laxton’s Superb was increased. Untreated trees on M.II rootstock, in contrast to those on M.VII, showed almost no foliar symptoms of magnesium deficiency, made more growth and produced larger crops; the concentrations of magnesium and calcium in the leaves were higher whereas potassium was usually lower. Epsom salt sprays did not increase growth or cropping; indeed, there was a tendency for sprays to reduce the crop weight of Beauty of Bath on M.II, indicating that they should not be used indiscriminately.

Epsom salt foliar sprays increased the “available” magnesium in the soil to a level considered to be medium—high; this effect was mainly shown in the top 6 in. of soil and gradually diminished to the 18–24 in. zone. Nevertheless, in the year following the termination of treatments, the proportion of foliage affected in Laxton’s Superb on M.VII, previously sprayed with Epsom salt, was almost as great as that of untreated trees and the concentration of magnesium in the leaves was as low. It appeared that magnesium in the soil did not reach the leaves.

The increase in “available” magnesium due to sprays was greater in soil carrying trees on M.II than M.VII, a result probably due to the extra quantity of spray required for these larger trees.  相似文献