Expression of the KIT protein (CD117) in primary cutaneous mast cell tumors of the dog.     

Rosario Preziosi  Maria Morini  Giuseppe Sarli 《Journal of veterinary diagnostic investigation》2004,16(6):554-561

Thirty-one canine cutaneous masses, diagnosed as mast cell tumors (MCT) by histopathologic analysis, were used to evaluate the immunohistochemical pattern of expression of KIT protein (CD117), a type III tyrosine kinase protein involved in mast cell growth and differentiation. Lesions were graded as I (well differentiated), II (intermediate differentiation), or III (poorly differentiated) according to the following morphologic features: invasiveness, cellularity and cellular morphology, mitotic index, and stromal reaction. Immunohistochemical KIT expression was compared with histologic grade and some histomorphologic features (cell differentiation and nuclear grade) evaluated separately. A possible predictive role of biologic behavior in MCTs for KIT expression was also investigated. Immunohistochemical analysis revealed three different patterns of KIT expression: a cytoplasmic diffuse pattern, a membranous pattern with immunostaining located on the cell surface, and a cytoplasmic perinuclear pattern, where KIT expression was detected in the cytoplasm of the neoplastic mast cells, close to the nucleus. Statistical analysis showed a close relationship between different KIT immunohistochemical patterns and histologic grade (P < 0.00000), cell differentiation (P < 0.00000), and nuclear grade (P < 0.0024). According to Kaplan-Meier-estimated survival curves compared by survival analysis, KIT expression was significantly associated with survival time (P = 0.037) but not cancer-free interval (P = 0.50). Similar to other well-known histomorphological features, KIT expression is a useful parameter of malignancy in cutaneous MCTs. KIT expression also predicted the biological behavior of the tumors in this study.  相似文献   

Detection of Cyprinid Herpesvirus 1 DNA in cutaneous squamous cell carcinoma of koi carp (Cyprinus carpio)          下载免费PDF全文

Rubina Sirri  Sara Ciulli  Tim Barbé  Enrico Volpe  Maurizio Lazzari  Valeria Franceschini  Francesca Errani  Giuseppe Sarli  Luciana Mandrioli 《Veterinary dermatology》2018,29(1):60-e24

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Relationship between serum cortisol levels and some physiological parameters following reining training session in horse          下载免费PDF全文

Stefania Casella  Irene Vazzana  Elisabetta Giudice  Francesco Fazio  Giuseppe Piccione 《Animal Science Journal》2016,87(5):729-735

The changes of cortisol, red blood cells (RBC), hemoglobin (Hb), hematocrit (Hct), heart rate (HR), respiratory rate (RR) and rectal temperature (RT) were evaluated after a reining training session in eight Quarter Horses. All parameters were measured before exercise (T0), immediately after exercise (T1), 1 h after exercise (T2), 2 h after exercise (T3) and 24 h after exercise (T4). One‐way analysis of variance (ANOVA) for repeated measures, followed Bonferroni's post hoc test, showed a significant effect of the reining training session (P < 0.0001) on cortisol, RBC, Hb, Hct, HR, RR and RT. Simple linear regression analysis showed the positive correlation (P < 0.05) between cortisol changes and variations of studied parameters in T1, T3 and T4. Exercise‐induced cortisol concentrations reflect the physiological response of reining training, suggesting that the changes observed are useful to assess the performance in reining horses and their reining training adaptability.  相似文献   

An alternative way to perform gastroscopy in large frogs and toads          下载免费PDF全文

Marco Di Giuseppe  Laura Faraci  Marco Luparello 《The Journal of small animal practice》2016,57(2):110-110

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Radiographic,MRI, and CT findings in a young dog with Becker-like muscular dystrophy     

Giulia Costanzo  Sergio Minei  Eric Zini  Margherita Gracis  Giuseppe Lacava 《Veterinary radiology & ultrasound》2023,64(2):E19-E22

An 8-month-old, male, crossbreed dog was presented for macroglossia, reduced mandibular extension, ptyalism, dysphagia, and regurgitation. Serum creatine kinase and aspartate aminotransferase activity were markedly increased. Thoracic radiographs showed an axial gastro-esophageal hiatal hernia, diaphragmatic thickening, and asymmetry. Magnetic resonance imaging of the head showed a severely enlarged tongue, symmetric increase in size of the geniohyoid and mylohyoid muscles, and diffuse masticatory hypomyotrophy. Whole-body CT ruled out other musculoskeletal abnormalities and further characterized the radiographic and MRI findings. Muscular histopathology was consistent with Becker muscular dystrophy.  相似文献   

hCG is more effective than the GnRH agonist buserelin for inducing the first ovulation of the breeding season in mares     

Diana Fanelli  Matteo Tesi  Alessandra Rota  Massimiliano Beltramo  Giuseppe Conte  Mario Giorgi  Giovanni Barsotti  Francesco Camillo  Duccio Panzani 《Equine veterinary journal》2022,54(2):306-311

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New biomarkers of the extinct speciesTaxodioxylori gypsaceum     

Giuseppe Staccioli  Giuseppe Bartolini 《Wood Science and Technology》1997,31(4):311-315

Summary The occurrence of layers of wood material beneath the soil of the fossil forest of Dunarobba (Italy) has provided the opportunity to study a differently degraded wood formed in the same environment of the fossil forest. The samples of subsoil have almost completely lost their polyose and cellulose fractions and, moreover, were deprived of most of their low and medium MW terpenes so that some phenolic diterpenes were revealed. The identified ones were ferruginol, podocarpodiol, traces of sugiol and a compound whose mass spectrum shows some similarities with that of sugiol. A family of compounds with ketonic structure was also detected: in particular tridecanone, pentadecanone and heptadecanone.Dr. G. Scarascia Mugnozza and Dr. Francesca Bozzano are thanked for fossils donation and Prof. Pasquale Miraglino for mass spectrometry analyses  相似文献   

Flavonol glycosides from Aconitum vulparia   总被引：1，自引：0，他引：1  

Fico G  Braca A  Morelli I  Tomè F 《Fitoterapia》2003,74(4):420-422

The isolation of five flavonol glycosides (1-5) from the flowers of Aconitum vulparia is reported, together with the 1H- and 13C-NMR spectral data in CD(3)OD of compound 3 and 5.  相似文献   

A new kaurane diterpene dimer from Parinari campestris     

Braca A  Abdel-Razik AF  Mendez J  Morelli I 《Fitoterapia》2005,76(7-8):614-619

A new kaurane diterpene dimer, 15-oxozoapatlin-13alpha-yl-10'alpha,16'alpha-dihydroxy-9'alpha-methyl-20'-nor-kauran-19'-oic acid gamma-lactone-17'-oate (1), together with the known 13-hydroxy-15-oxozoapatlin (2), 10alpha,13alpha,16alpha,17-tetrahydroxy-9alpha-methyl-15-oxo-20-nor-kauran-19-oic acid gamma-lactone (3), 2alpha,10alpha,13alpha,16alpha,17-pentahydroxy-9alpha-methyl-15-oxo-20-nor-kauran-19-oic acid (19,10)-lactone (4), 3alpha,10alpha,13alpha,16alpha,17-pentahydroxy-9alpha-methyl-15-oxo-20-nor-kauran-19-oic acid gamma-lactone (5), and 1beta,16alpha,17-trihydroxy-ent-kaurane (6) were isolated from the leaves of Parinari campestris and identified on the basis of detailed spectral analysis, including 2D NMR spectrometry and ESI-MS.  相似文献   

A new acylated quercetin glycoside from Ranunculus lanuginosus     

Maria Prieto J  Braca A  Morelli I  Barker A  Schaffner U 《Fitoterapia》2004,75(6):533-538

A new acylated quercetin glycoside, quercetin 3-O-(2-t-p-coumaroyl)-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (1), together with the known 3-(3,4-dihydroxyphenyl)lactic acid (2) were isolated from Ranunculus lanuginosus leaves and identified on the basis of detailed spectral analysis, including 2D-NMR spectrometry and ESI-MS.  相似文献