Acute oxalate toxicity of sheep associated with slender iceplant (Mesembryanthemum nodiflorum)     

RH JACOB  RL PEET 《Australian veterinary journal》1989,66(3):91-92

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In reply: verification of nuclear testing     

Hannon WJ 《Science (New York, N.Y.)》1985,228(4701):794

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Effects of energy conservation in residential and commercial buildings     

Hirst E  Hannon B 《Science (New York, N.Y.)》1979,205(4407):656-661

In 1977, heating, cooling, lighting, and other operations in residential and commercial buildings used 27 quads (1 quad = 10(15) British thermal units) of energy. This is more than one-third of the nation's total energy budget. Future trends in energy use in buildings are likely to depend strongly on fuel prices and government policies designed to save energy. Three scenarios are examined: (i) a base line in which fuel prices rise as projected by the Department of Energy; (ii) a conservation case that includes higher gas and oil prices plus the regulatory, financial incentive, and information programs authorized by the 94th Congress and proposed in the April 1977 National Energy Plan; and (iii) another conservation case that also includes new technologies (more efficient equipment, appliances, and structures). These scenarios are analyzed for changes in energy use, costs, and employment by means of detailed engineering-economic models of energy use in residential and commercial buildings developed at the Oak Ridge National Laboratory and input-output analyses developed at the University of Illinois.  相似文献   

Soft tissue sarcoma in a short‐beaked echidna (Tachyglossus aculeatus)          下载免费PDF全文

RL Robey  C Sangster  M Gabor  SA Lindsay 《Australian veterinary journal》2018,96(9):360-365

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Safety of Cartrophen Vet in the dog: review of adverse reaction reports in the UK     

Hannon RL  Smith JG  Cullis-Hill D  Ghosh P  Cawdery MJ 《The Journal of small animal practice》2003,44(5):202-208

Suspected adverse reactions (SARs) reported for Cartrophen Vet (100 mg sodium pentosan polysulphate/ml) to the Veterinary Medicines Directorate in the UK for the period January 1991 to October 1999 were reviewed. Of the 161 reports, 28 were probably product related, 54 were possibly product related, 71 were unlikely to be related and eight were unclassified. An estimated real incidence of adverse reactions probably and possibly associated with Cartrophen Vet of 0.074 per cent on an individual dose basis was calculated (assuming only 10 per cent were documented due to underreporting). Sixty-two SARs (38.5 per cent) documented emesis, 22 (35.5 per cent) of which were product related (onset five to 15 minutes after administration). Sixty-eight SARs (42.2 per cent) documented general changes to demeanour, 10 (14.7 per cent) were product related (lethargy and/or mild depression and/or mild inappetence lasting up to two days after administration). Six SARs were considered likely to be associated with concurrently administered carprofen. Cartrophen Vet had a low incidence of side effects that were mild and transitory.  相似文献   

Profiling essential genes in human mammary cells by multiplex RNAi screening     

Silva JM  Marran K  Parker JS  Silva J  Golding M  Schlabach MR  Elledge SJ  Hannon GJ  Chang K 《Science (New York, N.Y.)》2008,319(5863):617-620

By virtue of their accumulated genetic alterations, tumor cells may acquire vulnerabilities that create opportunities for therapeutic intervention. We have devised a massively parallel strategy for screening short hairpin RNA (shRNA) collections for stable loss-of-function phenotypes. We assayed from 6000 to 20,000 shRNAs simultaneously to identify genes important for the proliferation and survival of five cell lines derived from human mammary tissue. Lethal shRNAs common to these cell lines targeted many known cell-cycle regulatory networks. Cell line-specific sensitivities to suppression of protein complexes and biological pathways also emerged, and these could be validated by RNA interference (RNAi) and pharmacologically. These studies establish a practical platform for genome-scale screening of complex phenotypes in mammalian cells and demonstrate that RNAi can be used to expose genotype-specific sensitivities.  相似文献   

A MicroRNA feedback circuit in midbrain dopamine neurons   总被引：4，自引：0，他引：4  

Kim J  Inoue K  Ishii J  Vanti WB  Voronov SV  Murchison E  Hannon G  Abeliovich A 《Science (New York, N.Y.)》2007,317(5842):1220-1224

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Infertility in 2 Murray Grey bulls associated with abaxial and swollen midpiece sperm defects     

RL PEET  P. KLUCK  M. McCARTHY 《Australian veterinary journal》1988,65(11):359-360

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Lipolysis during ripening of Emmental cheese considering organization of fat and preferential localization of bacteria     

Lopez C  Maillard MB  Briard-Bion V  Camier B  Hannon JA 《Journal of agricultural and food chemistry》2006,54(16):5855-5867

This study followed the progression of lipolysis in Emmental cheese by quantifying the concentrations of individual free fatty acids (FFA) released during ripening in each of the different rooms: 12 days at 12 degrees C, 28 days at 21 degrees C, and 8 days at 4 degrees C. Lipolysis, which corresponded to 1.56% of fat, mainly occurred in the 21 and 4 degrees C rooms, with 68 and 16.5% of total FFA, respectively. The nonselectivity of lipolytic enzymes was evidenced: all fatty acids were released with level of > or =1%. Differential scanning calorimetry experiments showed that the thermal properties of cheese were affected by (i) lipolysis of fat, that is, the monoacylglycerols, diacylglycerols, and FFA that may be localized at the fat/whey interface, and/or by (ii) hydrolysis of high-melting-point triacylglycerols constituted mainly by long-chain saturated fatty acids (e.g., palmitic acid). Analysis of the cheese microstructure was performed using confocal laser scanning microscopy. Fat globules were mainly disrupted after pressing of curd grains, leading to the release of the milk fat globule membrane (MFGM); fat inclusions were surrounded by pockets of whey, delimited by casein strands. Moreover, colonies of bacteria were preferentially localized in situ at the fat/protein interface. This study showed that both the localization of bacteria and the supramolecular organization of fat which was not protected by the MFGM can help the accessibility of milk fat to lipolytic enzymes and then contribute to the quality of cheese.  相似文献   

Development of a real time PCR for the detection of Taylorella equigenitalis directly from genital swabs and discrimination from Taylorella asinigenitalis     

Wakeley PR  Errington J  Hannon S  Roest HI  Carson T  Hunt B  Sawyer J  Heath P 《Veterinary microbiology》2006,118(3-4):247-254

A discriminatory real time PCR for the detection of Taylorella equigenitalis, the causative agent of contagious equine metritis (CEM), and the related species T. asinigenitalis was developed for the direct examination of genital swabs. The 112bp amplicons produced from the two species were discriminated from each other using TaqMan probes labelled with different fluorophores. The TaqMan PCR was shown to be specific for the 16S ribosomal DNA of the two species of taylorella and did not cross-hybridise with the 16S ribosomal DNA of other bacteria tested. Direct amplification from genital swabs was shown to be equally sensitive to that of culture methods. Prevalence in a sample set from The Netherlands was shown to be equivalent to that demonstrated by culture. A companion real time PCR that amplified a fragment of the 16S rDNA gene of equine commensal bacteria was developed to ensure bacterial DNA was extracted from swab material supplied for testing. The use of a rapid and reliable real time PCR for the organism causing CEM should aid the control of this disease.  相似文献