Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera     

Elena V. Girich  Anton N. Yurchenko  Olga F. Smetanina  Phan Thi Hoai Trinh  Ngo Thi Duy Ngoc  Mikhail V. Pivkin  Roman S. Popov  Evgeny A. Pislyagin  Ekaterina S. Menchinskaya  Ekaterina A. Chingizova  Shamil S. Afiyatullov  Ekaterina A. Yurchenko 《Marine drugs》2020,18(12)

Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.  相似文献   

Lupus-Type "Anticoagulant" in a Dog With Hemolysis and Thrombosis   总被引：1，自引：1，他引：0  

Michael S. Stone  Ian B. Johnstone  Marjory Brooks  Trent K. Bollinger  Susan M. Cotter 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(1):57-61

A circulating anticoagulant was detected in a 2-year-old Chesapeake Bay Retriever with hemolytic anemia, nephrotic syndrome, thrombocytopenia, polyarthropathy, and pulmonary thromboembolism. A persistent prolongation of the activated partial thromboplastin time (aPTT) was detected, and it did not correct with repeated administration of fresh frozen plasma. The aPTT was still prolonged, with a 1:1 mixture of patient's plasma and normal dog plasma in vitro, suggesting the presence of a circulating inhibitor. Results of assays to characterize the inhibitor were compatible with those described for the lupus anticoagulant in human patients with systemic lupus erythematosus. Paradoxically, patients having the lupus anticoagulant are at increased risk for thrombosis. Pulmonary thromboembolism has been described as a frequent complication of immune-mediated hemolytic anemia in the dog, and the presence of a circulating anticoagulant should be considered as a potential mechanism.  相似文献   

AVA should speak with one voice     

Dr  Ian Denney 《Australian veterinary journal》2001,79(1):14-14

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A streak disease of pearl millet caused by a leafhopper-transmitted geminivirus     

Rob W. Briddon  Patricia Lunness  Ian D. Bedford  Leony C. L. Chamberlin  Theo Mesfin  Peter G. Markham 《European journal of plant pathology / European Foundation for Plant Pathology》1996,102(4):397-400

The cause of a streak disease of pearl millet (Pennisetum glaucum), originating from Nigeria, has been attributed to a geminivirus belonging to the African streak virus cluster. A full-length, infectious clone of the virus was obtained which was transmissible by the vectorCicadulina mbila (Naudé). Analysis of the complete nucleotide sequence of the coat protein gene of this virus shows it to be most closely related to sugarcane streak virus. The possible evolutionary implications of this finding are discussed.  相似文献   

THE EFFECTS OF PATIENT POSITIONING AND SLICE SELECTION ON CANINE ACETABULAR ANGLE ASSESSMENT WITH COMPUTED TOMOGRAPHY     

Sandy I. Wang  DVM    Kyle G. Mathews  DVM  MS    Ian D. Robertson  BVSc    Marty Stebbins  DVM  PhD    Brian J. Trumpatori  BS 《Veterinary radiology & ultrasound》2005,46(1):39-43

Acetabular angles (AAs) and dorsal acetabular rim angles acquired by computed tomographic (CT) imaging have been used to assess patient response to juvenile pubic symphysiodesis surgery. The purpose of this study was to evaluate the effects of patient positioning and slice selection on these angles, and an attempt was made to devise a repeatable method of measuring these angles that would eliminate positioning effects. We found significant variation in AAs with small differences in pelvic tilt and slice selection. Dorsal acetabular rim angles were not affected. As a result of positioning differences from one CT study to the next, every attempt should be made to standardize pelvic tilt, or eliminate its effect on AAs by standardizing gantry angle in relation to an anatomic landmark that will not change over time. The floor of the sacral vertebral canal may be a reasonable landmark for this purpose and deserves further study.  相似文献   

Effect of parental origin on early life history traits of European eel          下载免费PDF全文

Sebastian N. Politis  Johanna S. Kottmann  Ian A. E. Butts  Sune R. Sørensen  Jonna Tomkiewicz 《Reproduction in domestic animals》2018,53(5):1149-1158

Establishment of European eel (Anguilla anguilla) hatchery production will rely on selectively bred individuals that produce progeny with the best traits in successive generations. As such, this study used a quantitative genetic breeding design, between four females and nine males (four wild‐caught and five cultured), to investigate the effect of paternal origin (wild‐caught vs. cultured) and quantify the relative importance of parental effects, including genetic compatibility, on early life history (ELH) performance traits (i.e. fertilization success, embryonic survival at 32 hr post‐fertilization, hatch success and larval deformities at 2 days post‐hatch) of European eel. Wild‐caught males had higher (56%) spermatocrit values than cultured males (45%), while fertilization success, embryonic survival, hatch success and larval deformities were not significantly impacted by paternal origin. This demonstrates that short‐term domestication of male eels does not negatively affect offspring quality and enables the consideration of cultured male broodstock in future breeding programmes. Moreover, paternity significantly explained 9.5% of the variability in embryonic survival, providing further evidence that paternal effects need to be taken into consideration in assisted reproduction protocols. Furthermore, maternity significantly explained 54.8% of the variation for fertilization success, 61.7% for embryonic survival, 88.1% for hatching success and 62.8% for larval deformities, validating that maternity is a major factor influencing these “critical” ELH traits. At last, the parental interaction explained 12.8% of the variation for fertilization success, 8.3% for embryonic survival, 4.5% for hatch success and 20.5% for larval deformities. Thus, we conclude that eggs of one female can develop more successfully when crossed with a compatible male, highlighting the importance of mate choice for successful propagation of high‐quality offspring. Together, this knowledge will improve early offspring performance, leading to future breeding programmes for this critically endangered and economically important species.  相似文献   

Distribution,characteristics and condition of Arctic charr (Salvelinus alpinus) spawning grounds in a differentially eutrophicated twin‐basin lake          下载免费PDF全文

Helen Miller  Ian J. Winfield  Janice M. Fletcher  J. Ben James  Joey van Rijn  Jonathan M. Bull  Carol J. Cotterill 《Ecology of Freshwater Fish》2015,24(1):32-43

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Groundwater monitoring for 1,3‐dichloropropene in high fumigant use areas of North America and Europe     

Ian J van Wesenbeeck  Steve Knowles 《Pest management science》2019,75(8):2278-2282

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Fungal volatile organic compounds show promise as potent molluscicides     

Salim Khoja  Khalifa M Eltayef  Ian Baxter  James C Bull  Edric Joel Loveridge  Tariq Butt 《Pest management science》2019,75(12):3392-3404

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Geopedology. By J.A. Zinck,G. Metternicht,G. Bocco & H.F. Del Valle (eds). Published by Springer,Cham Heidelberg, 2016, xiv + 555 pp. £66.99. Hardback (ISBN 978‐3‐319‐19158‐4).          下载免费PDF全文

Ian Baillie 《Soil Use and Management》2017,33(1):174-174

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