Effects of low and high calcium intake prepartum on calcium mobilization rate around parturition in dairy cows     

A E van de Braak  A T van 't Klooster  A Malestein  J A Faber 《The Veterinary quarterly》1986,8(1):12-23

Forty-one dairy cows were fed a low (LCa-13 g/d) and a high (HCa-83.5 g/d) calcium ration in the 8 weeks prior to parturition and the effect on the Ca mobilization rate around parturition was studied. Plasma Ca values were stable in the LCa group around parturition. In the older cows of the HCa group a very slight decrease in the mean plasma Ca was observed: 2.58 mmol/l at 12-36 h ante partum decreased to 2.38 mmol/l at parturition. Hypocalcaemia, which commonly occurs around parturition, did not occur in 40 of the cows. A subclinical hypocalcaemia (1.8 mmol/l) occurred in one cow (parity 10) from the HCa group. To assess the efficiency of Ca mobilization, a severe hypocalcaemia (1.0 mmol/l) with clinical signs was induced by means of Na2EDTA infusion (0.90 mmol/min), starting at 10 h post-partum. The older cows in the LCa group required more Na2EDTA than those in the HCa group. Higher urinary hydroxyproline excretion in the week before parturition in the LCa than in the HCa group suggested a higher bone turnover. Plasma PTH levels around parturition were not significantly different between the groups. The amount of colostrum milked out in the first 10 h post-partum did not influence Ca homeostasis around parturition. The results contradict those of many other experiments in which hypocalcaemia was observed in cows ingesting high levels of Ca. It is concluded that the restricted feed intake prepartum possibly had a favourable effect on Ca homeostasis.  相似文献   

Influence of clay content and acidity of soil on development of the earthworm <Emphasis Type="Italic">Lumbricus rubellus</Emphasis> and its population level consequences     

Chris Klok  Jack Faber  Guido Heijmans  Jos Bodt  Annemariet van der Hout 《Biology and Fertility of Soils》2007,43(5):549-556

In this paper we report on the influence of clay content and acidity of soil on growth and reproduction of the epigeic earthworm species Lumbricus rubellus (Hoffm.), which is common in most temperate soils and abundant in grasslands. Growth, cocoon production and survival of L. rubellus were tested in 12 Dutch soils which differed in soil properties. A matrix model was used to assess the population-level consequences of changes in growth and reproduction. Soil acidity had a strong negative effect on earthworm survival, and the maturation weight decreased with clay content. Individual weight gain in L. rubellus decreased with both acidity and clay content. The acidity of soils had a larger influence on population growth rate than the clay content. The acidity of the soil also changed the population composition towards younger age classes, whereas in soils rich in clay, the population composition did not change. The average individual weight of L. rubellus in clayey soils, however, was lower compared with that in soils low in clay, a result that agrees with literature data.  相似文献   

Increased vitamin A intake in children aged 2-5 years through targeted home-gardens in a rural South African community     

Faber M  Venter SL  Benadé AJ 《Public health nutrition》2002,5(1):11-16

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Strychnine- and pentylenetetrazol-induced changes of excitability in Aplysia neurons   总被引：4，自引：0，他引：4  

M R Klee  D S Faber  W D Heiss 《Science (New York, N.Y.)》1973,179(78):1333-1336

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Single-shot channel activation accounts for duration of inhibitory postsynaptic potentials in a central neuron   总被引：4，自引：0，他引：4  

D S Faber  H Korn 《Science (New York, N.Y.)》1980,208(4444):612-615

In the goldfish Mauthner cell, inhibitory postsynaptic currents evoked by intracellular stimulation of presynaptic neurons decay exponentially, with a mean time constant of 6.65 milliseconds. Analysis of membrane conductance fluctuations induced by iontophoresis of glycine and gamma-aminobutyric acid indicates a mean inhibitory channel lifetime of 7.15 milliseconds. The results thus suggest that the relaxation kinetics of activated inhibitory channels are rate-limiting during decay of the inhibitory postsynaptic current.  相似文献   

Crystal structure of the malaria vaccine candidate apical membrane antigen 1     

Pizarro JC  Vulliez-Le Normand B  Chesne-Seck ML  Collins CR  Withers-Martinez C  Hackett F  Blackman MJ  Faber BW  Remarque EJ  Kocken CH  Thomas AW  Bentley GA 《Science (New York, N.Y.)》2005,308(5720):408-411

Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding. We also mapped the epitope of an invasion-inhibitory monoclonal antibody specific for the P. falciparum ortholog and modeled this to the structure. The location of the epitope and current knowledge on structure-function correlations for PAN domains together suggest a receptor-binding role during invasion in which domain II plays a critical part. These results are likely to aid vaccine and drug design.  相似文献   

Urbanisation and cariogenic food habits among 4-24-month-old black South African children in rural and urban areas     

MacKeown JM  Faber M 《Public health nutrition》2002,5(6):719-726

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Use of bethanechol and metoclopramide in horses with duodenitis/proximal jejunitis: 13 cases (1987–1993)     

N.D. Cohen VMD  MPH  PhD  N.A. Faber DVM  G.W. Brumbaugh DVM  PhD 《Journal of Equine Veterinary Science》1995,15(11)

All horses diagnosed with duodenitis/proximal jejunitis (DPJ) at the Texas Veterinary Medican Center between January 1, 1987 and July 1, 1993 were included in a retrospective study to evaluate the therapeutic and prognostic value of bethanechol and metoclopramide as gastrointestinal prokinetic drugs in horses with DPJ treated at our clinic, and to compare the clinical outcome of horses with DPJ treated with these drugs and those with DPJ that were not treated. During the study period, 70 horses diagnosed with DPJ were admitted to the clinic. Of these 70 horses, 18(25.7%) were treated with bethanechol, metoclopramide, or both; 13 of the 18 treated horses received more than one dose of either drug. No adverse effects of treatment with these drugs were noted. A precise therapeutic plan and clinical benefit of bethanechol, metoclopramide, or both coul not be determined from this retrospective study. The use of these gastrointestinal prokinetic drugs in horses with DPJ appeared to have prognostic value. Horses that did not respond to treatment with these gastrointestinal prokinetic drugs within 24 hours were not discharged alive.  相似文献   

The sablefish (Anoplopoma fimbria) karyotype including the location of 5S and 18S rDNA and information on cell culture conditions     

Ruth B Phillips  Joshua Faber‐Hammond  John Adam Luckenbach 《Aquaculture Research》2013,44(11):1801-1804

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Survival of plant pathogens in static piles of ground green waste     

Downer AJ  Crohn D  Faber B  Daugovish O  Becker JO  Menge JA  Mochizuki MJ 《Phytopathology》2008,98(5):547-554

Ground green waste is used as mulch in ornamental landscapes and for tree crops such as avocados. Survival of Armillaria mellea, Phytophthora cinnamomi, Sclerotinia sclerotiorum, and Tylenchulus semipenetrans was assessed for 8 weeks within unturned piles of either recently ground or partially composted green waste. S. sclerotiorum survived at the pile surface and at 10, 30, and 100 cm within the pile for the entire 8 weeks in both fresh green waste (FGW) and aged green waste (AGW). A. mellea and T. semipenetrans did not survive more than 2 days in FGW, while P. cinnamomi persisted for over 21 days in FGW. AGW was less effective in reducing pathogen viability than FGW, most likely because temperatures in AGW peaked at 45 degrees C compared with 70 degrees C in FGW. Survival modeling curves based on pile temperatures indicate the time to inactivate 10 propagules of pathogens was 11, 30, 363, and 50 days for A. mellea, P. cinnamomi, S. sclerotiorum, and T. semipenetrans, respectively. Sclerotia-forming pathogens pose the greatest risk for escape; to ensure eradication of persistent fungi, green waste stockpiles should be turned intermittently to mix pile contents and move pathogen propagules to a location within the pile where they are more likely to be killed by heat, microbial attack, or chemical degradation.  相似文献