Use of a controlled-release albendazole capsule in goats     

NC SANGSTER  JM RICKARD  GH COLLINS  DR HENNESSY  JW STEEL 《Australian veterinary journal》1992,69(3):67-68

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Colour mutant alopecia in a Kelpie ×Border Collie dog     

JW FINNIE  VL THAM 《Australian veterinary journal》1993,70(10):388-389

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Reply     

SE RIDGE  JW GALVIN 《Australian veterinary journal》2005,83(12):767-767

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Perivascular wall tumour presenting as pastern mass in a Standardbred gelding     

M Stutsel  M Gimeno  A Young  JW Bell  N Horadagoda 《Australian veterinary journal》2023,101(11):445-448

A 2-year-old Standardbred gelding was referred for a mass on the palmaromedial right front pastern which was accompanied by progressively worsening lameness. The mass was firm to palpation and covered by normal skin. Ultrasonographically, a smooth encapsulated mass was present, medial to the flexor tendons and palmar to the neurovascular bundle. Because of a poor prognosis for future athletic performance without surgical or chemotherapeutic intervention and economic constraints preventing further diagnostics and treatment, the horse was euthanised. Post-mortem magnetic resonance imaging, histopathology and immunohistochemistry revealed the mass to be a perivascular wall tumour, the first record of such a neoplasia in the horse.  相似文献   

Efficient computation of genotype probabilities for loci with many alleles: I. Allelic peeling     

Thallman RM  Bennett GL  Keele JW  Kappes SM 《Journal of animal science》2001,79(1):26-33

Genetic marker data are likely to be obtained from a relatively small proportion of the individuals in many livestock populations. Information from genetic markers can be extrapolated to related individuals without marker data by computing genotype probabilities using an algorithm referred to as peeling. However, genetic markers may have many alleles and the number of computations in traditional peeling algorithms is proportional to the number of alleles raised to the sixth or eighth power, depending on pedigree structure. An alternative algorithm for computing genotype probabilities of marker loci with many alleles in large, nonlooped pedigrees with incomplete marker data is presented. The algorithm is based on recursive computations depending on alleles instead of genotypes, as in traditional peeling algorithms. The number of computations in the allelic peeling algorithm presented here is proportional to the square of the number of alleles, which makes this algorithm more computationally efficient than traditional peeling for loci with many alleles. Memory requirements are roughly proportional to the number of individuals in the pedigree and the number of alleles. The recursive allelic peeling algorithm cannot be applied to pedigrees that include full sibs or loops. However, it is a preliminary step toward a more complex and encompassing iterative approach to be described in a companion paper.  相似文献   

Detection of quantitative trait loci for growth and carcass composition in cattle   总被引：12，自引：0，他引：12  

Casas E  Shackelford SD  Keele JW  Koohmaraie M  Smith TP  Stone RT 《Journal of animal science》2003,81(12):2976-2983

The objective of the present study was to detect quantitative trait loci for economically important traits in a family from a Bos indicus x Bos taurus sire. A Brahman x Hereford sire was used to develop a half-sib family (n = 547). The sire was mated to Bos taurus cows. Traits analyzed were birth (kg) and weaning weights (kg); hot carcass weight (kg); marbling score; longissimus area (cm2); USDA yield grade; estimated kidney, pelvic, and heart fat (%); fat thickness (cm); fat yield (%); and retail product yield (%). Meat tenderness was measured as Warner-Bratzler shear force (kg) at 3 and 14 d postmortem. Two hundred and thirty-eight markers were genotyped in 185 offspring. One hundred and thirty markers were used to genotype the remaining 362 offspring. A total of 312 markers were used in the final analysis. Seventy-four markers were common to both groups. Significant QTL (expected number of false-positives < 0.05) were observed for birth weight and longissimus area on chromosome 5, for longissimus area on chromosome 6, for retail product yield on chromosome 9, for birth weight on chromosome 21, and for marbling score on chromosome 23. Evidence suggesting (expected number of false-positives < 1) the presence of QTL was detected for several traits. Putative QTL for birth weight were detected on chromosomes 1, 2, and 3, and for weaning weight on chromosome 29. For hot carcass weight, QTL were detected on chromosomes 10, 18, and 29. Four QTL for yield grade were identified on chromosomes 2, 11, 14, and 19. Three QTL for fat thickness were detected on chromosomes 2, 3, 7, and 14. For marbling score, QTL were identified on chromosomes 3, 10, 14, and 27. Four QTL were identified for retail product yield on chromosomes 12, 18, 19, and 29. A QTL for estimated kidney, pelvic, and heart fat was detected on chromosome 15, and a QTL for meat tenderness measured as Warner-Bratzler shear force at 3 d postmortem was identified on chromosome 20. Two QTL were detected for meat tenderness measured as Warner-Bratzler shear force at 14 d postmortem on chromosomes 20 and 29. These results present a complete scan in all available progeny in this family. Regions underlying QTL need to be assessed in other populations.  相似文献   

Evaluation of single-nucleotide polymorphisms in CAPN1 for association with meat tenderness in cattle   总被引：24，自引：0，他引：24  

Page BT  Casas E  Heaton MP  Cullen NG  Hyndman DL  Morris CA  Crawford AM  Wheeler TL  Koohmaraie M  Keele JW  Smith TP 《Journal of animal science》2002,80(12):3077-3085

Micromolar calcium activated neutral protease (CAPN1) was evaluated as a candidate gene for a quantitative trait locus (QTL) on BTA29 affecting meat tenderness by characterization of nucleotide sequence variation in the gene. Single-nucleotide polymorphisms (SNP) were identified by sequencing all 22 exons and 19 of the 21 introns in two sires (Piedmontese x Angus located at the U.S. Meat Animal Research Center in Clay Center, NE; Jersey x Limousin located at AgResearch in New Zealand) of independent resource populations previously shown to be segregating meat tenderness QTL on BTA29. The majority of the 38 SNP were found in introns or were synonymous substitutions in the coding regions, with two exceptions. Exons 14 and 9 contained SNP that were predicted to alter the protein sequence by the substitution of isoleucine for valine in Domain III of the protein, and alanine for glycine in Domain II of the protein. The resource populations were genotyped for these two SNP in addition to six intronic polymorphisms and two silent substitutions. Analysis of genotypes and shear force values in both populations revealed a difference between paternal CAPN1 alleles in which the allele encoding isoleucine at position 530 and glycine at position 316 associated with decreased meat tenderness (increased shear force values) relative to the allele encoding valine at position 530 and alanine at position 316 (P < 0.05). The association of maternal alleles with meat tenderness phenotypes is consistent with the hypothesis of CAPN1 as the gene underlying the QTL effect in two independent resource populations and presents the possibility of using these markers for selective breeding to reduce the numbers of animals with unfavorable meat tenderness traits.  相似文献   

Initial results of genomic scans for ovulation rate in a cattle population selected for increased twinning rate   总被引：2，自引：0，他引：2  

Kappes SM  Bennett GL  Keele JW  Echternkamp SE  Gregory KE  Thallman RM 《Journal of animal science》2000,78(12):3053-3059

Genomic scans were conducted with 273 markers on 181 sires from a cattle population selected for increased twinning rate to identify chromosomal regions containing genes that influence ovulation rate. Criteria used for selecting markers were number of alleles, ease of scoring, and relative position within linkage group. Markers were multiplexed or multiple-loaded on the gels to reduce the costs and labor required to obtain genotypic data. This approach reduced the number of gels by 45% when compared with running each marker independently. Male animals selected for the genomic scan sired the majority of the population. A modified interval analysis was used in a granddaughter design to compare effects of each allele within sire for 10 different sire families. The midparent deviation of the son's estimated breeding value for ovulation rate was used as the phenotype. Forty-one potential peaks were identified with a nominal significance level < or = 0.05. The 10 peaks with the highest significance levels (P < 0.02) were selected for further analysis. Markers were genotyped across daughters of the sire where nominal significance was found for each of the 10 peaks. One peak (BTA5, relative position 40 cM) was found to be nominally significant in the daughters. The nominal significance levels were P = 0.01 for the sons (n = 32) and P = 0.02 for the daughters (n = 94) of sire 784403. A combined genomewide significance value (P = 0.07) was calculated that accounted for the 10 analyses with sons and the 10 analyses with daughters. These results strongly suggest that this region contains a gene(s) that is involved in the follicular recruitment and development process.  相似文献   

Bovine CAPN1 maps to a region of BTA29 containing a quantitative trait locus for meat tenderness   总被引：21，自引：0，他引：21  

Smith TP  Casas E  Rexroad CE  Kappes SM  Keele JW 《Journal of animal science》2000,78(10):2589-2594

Micromolar calcium activated neural protease (CAPN1) was investigated as a potential candidate gene for a quantitative trait locus (QTL) on BTA29 affecting meat tenderness. A 2,948-bp bovine cDNA containing the entire coding region of the gene was obtained, showing 91% identity to human CAPN1. The 716 AA protein predicted from this sequence shows 97% similarity (95% identity) to the 714 AA human protein. Analysis of the gene structure revealed that CAPN1 mRNA is encoded by at least 19 exons, and 11,055 bp of the gene were sequenced, including 17 introns. Two single nucleotide polymorphisms (SNP) were detected in intron 12 and were used to map bovine CAPN1 to the telomeric end of the BTA29 linkage group. This approximately coincides with the position of the QTL, demonstrating that CAPN1 protease is a positional candidate gene potentially affecting variation in meat tenderness in a bovine resource mapping population.  相似文献   

Impact of Endocrine‐Disrupting Chemicals on Reproductive Function in Zebrafish (Danio rerio)          下载免费PDF全文

Y Huang  XL Wang  JW Zhang  KS Wu 《Reproduction in domestic animals》2015,50(1):1-6

The prevalence of endocrine‐disrupting chemicals (EDCs) in the aquatic environment has been associated with the wide detection of alterations in the development and physiology of vertebrates. Zebrafish, as a model species, has been extensively used in toxicological research. In this review, we focus on recent published evidence of the harmful effects of EDCs on reproductive function in zebrafish, including skewed sex ratio, immature gonads, diminished sexual behaviour, decreased sperm count, reduced spawning and fertilization. These impairments mostly result from disruption to sex‐steroid hormones induced by endocrine disruptors. We also discuss other effects of exposure to EDCs. In EDC exposure research, despite incomplete assessments of altered gonad histopathology and sexual behaviour, these present potential effective biomarkers or pathways for evaluating the reproductive function in zebrafish on EDC exposure. To date, the pernicious effects of some EDCs on the reproductive performance in laboratory zebrafish are well understood; however, similar alterations remain for further determination in wild‐type fish and more kinds of EDCs. More studies should be performed under established scientific regulatory criteria to investigate the impact of EDCs on reproduction in zebrafish. Moreover, further research is required to explain the definite mechanism of sexual differentiation, which helps in understanding the shift of sexual phenotype with EDC exposure.  相似文献