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Mariko TAKAYASU Kouko HAMAMOTO Hiroshi SATOH Toshihiro ICHIJO Toru TAKAHASHI Kazuhisa FURUHAMA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(2):261-263
To clarify the effect of renal dysfunction on pharmacokinetics of the prokinetic agent metoclopramide (MCP), we administered intravenously 0.4 mg/kg MCP to healthy calves and calves subjected to right kidney vessel ligation (ligation) without or with a subsequent left nephrectomy (ligation plus removal). Plasma MCP concentration, glomerular filtration rate (GFR) and plasma prolactin level were measured by liquid chromatography-tandem mass spectrometry, simplified equation using iodixanol and enzyme-linked immunosorbent assay, respectively. Only in calves with ligation plus removal, plasma MCP concentrations were increased significantly 6, 8 and 12 hr after injection, showing that a negative correlation was observed between the plasma MCP concentrations and GFR value. A tendency to increase in plasma PRL concentration was noted also in these calves. In conclusions, plasma MCP concentrations depend on the GFR mode in calves, and its critical GFR value was estimated. 相似文献
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Kouko HAMAMOTO Yasuharu MIZUNO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1527-1529
We assessed ampicillin (ABPC) concentrations of kidney, muscle and intestine
after a 5–day withdrawal period in 2 male and a female young Large White pigs fed the diet
containing ABPC (ABPC medicated feed, 24 mg/kg/day) for a week. The ABPC residues were
measured with liquid chromatography–tandem mass spectrometry, and the mean recoveries and
quantitation limits ranged from 91.8 to 97.2% and from 0.1 to 0.12 ng/g,
respectively. The residual ABPC concentrations were ≤1.18 ng/g for the
muscle, ≤0.53 ng/g for the kidney and ≤1.93 ng/g for the
intestine, suggesting below the Japanese provisional maximum residue limits. These results
reveal that the analytical method is developed for residual ABPC and that the withdrawal
period is appropriate. 相似文献
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Young-Jin LEE Hiroshi HAMAMOTO Ryoji NAKAUNE Osamu NAWATA Yoshiyuki MAKIZUMI Katsumi AKUTSU Tadaaki HIBI 《Journal of General Plant Pathology》2001,67(2):106-110
The distribution of ABC (ATP-binding cassette) transporter genes among several taxonomically distinct phytopathogenic fungi was investigated by Southern blot hybridization,
polymerase chain reaction assays and partial sequencing. Consensus sequences of the ABC transporter gene, which might be concerned
with multidrug resistance against fungicides and with pathogenicity in phytopathogenic fungi, were found in all of the examined
phytopathogenic fungi, which belonged to the Mastigomycotina, Ascomycotina, Basidiomycotina and Deuteromycotina.
Received 24 August 2000/ Accepted in revised form 5 December 2000 相似文献
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Rikako ASADA Yuji HAMAMOTO Yoshihiko YU Satoshi MIZUNO James K. CHAMBERS Kazuyuki UCHIDA Daisuke HASEGAWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(10):1513
Anterior temporal lobectomy (ATL) is a surgical procedure for drug-resistant mesial temporal lobe epilepsy that is commonly performed in human medicine. The purpose of this study was to determine whether ATL-like surgery, i.e., removal of the amygdala and hippocampal head, is possible in dogs, and to investigate its safety and postoperative complications. Eight healthy beagles underwent ATL-like surgery and were observed for 3 months postoperatively. Samples from the surgically resected tissues and postmortem brain were evaluated pathologically. The surgical survival rate was 62.5%. The major postoperative complications were visual impairment, temporal muscle atrophy on the operative side, and a postoperative acute symptomatic seizure. Due to the anatomical differences between dogs and humans, the surgically resected area to approach the medial temporal structures in dogs was the ventrolateral part of the temporal lobe. Therefore, the ATL-like surgery described in this study was named “ventrolateral temporal lobectomy” (VTL). This study is the first report of temporal lobectomy including amygdalohippocampectomy in veterinary medicine and demonstrates its feasibility. Although it requires some degree of skill, VTL could be a treatment option for canine drug-resistant epilepsy and lesions in the mesial temporal lobe. 相似文献
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Yoshiyuki MAKIZUMI Shin-ichi TAKEDA Yuichi MATSUZAKI Ryoji NAKAUNE Hiroshi HAMAMOTO Katsumi AKUTSU Tadaaki HIBI 《Journal of General Plant Pathology》2002,68(4):338-341
Two genes, BMR1 and BMR3, encoding new members of the ABC superfamily in Botrytis cinerea, were cloned and characterized. The topologies of the encoded proteins, BMR1 and BMR3, were both (NBF-TMD6)2, similar to most of the toxicant-efflux ABC transporters. These genes had different induced expression patterns after treatment
with various toxicants, suggesting they may have different roles in toxicant-resistance.
Received 24 September 2002/ Accepted in revised form 2 December 2002 相似文献
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Masae WADA Daisuke HASEGAWA Yuji HAMAMOTO Atsushi ASAI Akane SHOUJI James CHAMBERS Kazuyuki UCHIDA Michio FUJITA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2016,78(1):101-104
A 12-year-old spayed female Labrador retriever was presented with forebrain
signs. Brain MRI revealed a huge cystic lesion with the thickened falx in the frontal
region. The brain parenchyma surrounding the lesion showed significant signs of a mass
effect and also increased intracranial pressure. However, the dog suddenly became lucid
after about two weeks, and an MRI scan one month after the initial study revealed a
dramatically shrunken cystic lesion. The dog survived for over a year until it was
euthanized for other reasons, and the brain lesion was diagnosed as a cystic meningioma
histologically. To the authors’ knowledge, this is the first report that described the
reduction of the cystic lesion of a cystic meningioma in dogs. 相似文献
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