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Laible G 《Comparative immunology, microbiology and infectious diseases》2009,32(2):123-137
Transgenic technology allows for the stable introduction of exogenous genetic information into livestock genomes. With its ability to enhance existing or introduce entirely novel characteristics at unprecedented magnitude and speed this emerging technology is expected to have a profound impact on the genetic improvement of livestock in the future. The continual advances in animal genomics towards the identification of genes that influence livestock production traits and impact on human health will increase its ability and versatility for the purposeful modification of livestock animals to enhance their welfare, produce superior quality food and biomedical products and reduce the environmental impact of farming. In contrast to biomedicine, which has so far been the main driver for this technology platform, the potential opportunities for animal agriculture are more challenging because of the greater demands on cost, efficiency, consumer acceptance and relative value of the product. While various transgenic concepts for the genetic improvement of livestock animals for agriculture are being evaluated the integration of this technology into practical farming systems remains some distance in the future. 相似文献
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Turin L. Tribbioli G. Invernizzi P. Grati F. R. Crema S. Laible G. Riva F. 《Veterinary research communications》2007,31(1):205-207
Veterinary Research Communications - Turin, L., Tribbioli, G., Invernizzi, P., Grati, F.R., Crema, S., Laible, G. and Riva, F., 2007. Fetal microchimerism in normal and embryo transfer bovine... 相似文献
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Selting KA Ogilvie GK Gustafson DL Long ME Lana SE Walton JA Hansen RA Turner AS Laible I Fettman MJ 《American journal of veterinary research》2006,67(1):145-151
OBJECTIVE: To determine the effect of dietary n-3 fatty acids on the pharmacokinetics of doxorubicin in dogs with lymphoma. ANIMALS: 23 dogs with lymphoma in stages IIIa, IVa, and Va. PROCEDURE: Dogs receiving doxorubicin chemotherapy were randomly allocated to receive food with a high (test group) or low (control group) content of n-3 fatty acids. Serum doxorubicin and doxorubicinol concentrations were measured via high-performance liquid chromatography before and 6 to 9 weeks after initiation of the diets. Lymph node concentrations of doxorubicin were assessed 6 hours after the initial treatment. Dogs' body composition was assessed by means of dual-energy x-ray absorptiometry scans. RESULTS: No significant differences in doxorubicin pharmacokinetics were detected between treatment groups. Significant differences existed between the first and second sampling times among all dogs for area under the curve, maximum serum concentration, and clearance. Differences in body composition did not affect measured pharmacokinetic variables. The terminal elimination half-life was longer in dogs in which a long-term remission was achieved than in dogs that did not have remission. CONCLUSIONS AND CLINICAL RELEVANCE: Dietary supplementation of n-3 fatty acids is common in veterinary patients with neoplasia, but supplementation did not affect doxorubicin pharmacokinetics in this population of dogs. Explanations for the beneficial effects of n-3 fatty acids other than alterations in the pharmacokinetics of chemotherapy drugs should be investigated. Dogs may metabolize drugs differently prior to remission of lymphoma than when in remission. The pharmacokinetics of doxorubicin at the time of the first administration may predict response to treatment. 相似文献
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