Squamous cell carcinoma of the corneoscleral limbus in a dog.     

D A Ward  K S Latimer  R M Askren 《Journal of the American Veterinary Medical Association》1992,200(10):1503-1506

Squamous cell carcinoma is an uncommon tumor of the cornea in dogs. A 12-year-old Shih Tzu with a history of chronic keratoconjunctivitis sicca was diagnosed as having squamous cell carcinoma of the corneoscleral limbus. The lesion was treated by surgical resection and cryotherapy. One year after surgery, multiple tumors, apparently unrelated to the first tumor, appeared on the same cornea. Keratoconjunctivitis sicca may have predisposed the dog to corneal squamous cell carcinoma development.  相似文献   

UV-B radiation and photosynthetic irradiance acclimate eggplant for outdoor exposure     

Latimer JG  Mitchell CA  Mitchell GA 《HortScience : a publication of the American Society for Horticultural Science》1987,22(3):426-429

Treatment of greenhouse-grown eggplant (Solanum melongena L. var. esculentum Nees. 'Burpee's Black Beauty') seedlings with supplemental photosynthetically active radiation from cool-white fluorescent lamps increased growth of plants subsequently transferred outdoors relative to growth of plants that received no supplemental radiation or were shaded to 45% of solar irradiation in the greenhouse before transfer outdoors. Eggplant seedlings transferred outdoors were placed under plastic tarps either to provide relative protection from solar ultraviolet-B (UV-B) radiation (280-315 nm) using Mylar film or to allow exposure to UV-B using cellulose acetate. Protection of seedlings from UV-B radiation resulted in greater leaf expansion than for UV-B-exposed seedlings, but no change in leaf or shoot dry weight occurred after 9 days of treatment. Specific leaf weight increased in response to UV-B exposure outdoors. Exposure of eggplant to UV-B radiation from fluorescent sunlamps in the greenhouse also decreased leaf expansion and leaf and shoot dry weight gain after 5 days of treatment. However, there were no differences in leaf or shoot dry weight relative to control plants after 12 days of UV-B treatment, indicating that UV-B treated plants had acclimated to the treatment and actually had caught up with non-UV-B-irradiated plants in terms of growth.  相似文献   

Proposed criteria for classification of acute myeloid leukemia in dogs and cats     

Jain NC  Blue JT  Grindem CB  Harvey JW  Kociba GJ  Krehbiel JD  Latimer KS  Raskin RE  Thrall MA  Zinkl JG 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1991,20(3):63-82

Blood and bone marrow smears from 49 dogs and cats, believed to have myeloproliferative disorders (MPD), were examined by a panel of 10 clinical pathologists to develop proposals for classification of acute myeloid leukemia (AML) in these species. French-American-British (FAB) group and National Cancer Institute (NCI) workshop definitions and criteria developed for classification of AML in humans were adapted. Major modifications entailed revision of definitions of blast cells as applied to the dog and cat, broadening the scope of leukemia classification, and making provisions for differentiating erythremic myelosis and undifferentiated MPD. A consensus cytomorphologic diagnosis was reached in 39 (79.6%) cases comprising 26 of AML, 10 of myelodysplastic syndrome (MDS), and 3 of acute lymphoblastic leukemia (ALL). Diagnostic concordance for these diseases varied from 60 to 81% (mean 73.3 +/- 7.1%) and interobserver agreement ranged from 51.3 to 84.6% (mean 73.1 +/- 9.3%). Various subtypes of AML identified included Ml, M2, M4, M5a, M5b, and M6. Acute undifferentiated leukemia (AUL) was recognized as a specific entity. M3 was not encountered, but this subclass was retained as a diagnostic possibility. The designations M6Er and MDS-Er were introduced where the suffix "Er" indicated preponderance of erythroid component. Chief hematologic abnormalities included circulating blast cells in 98% of the cases, with 36.7% cases having >30% blast cells, and thrombocytopenia and anemia in approximately 86 to 88% of the cases. Bone marrow examination revealed panmyeloid dysplastic changes, particularly variable numbers of megaloblastoid rubriblasts and rubricytes in all AML subtypes and increased numbers of eosinophils in MDS. Cytochemical patterns of neutrophilic markers were evident in most cases of Ml and M2, while monocytic markers were primarily seen in M5a and M5b cases. It is proposed that well-prepared, Romanowsky-stained blood and bone marrow smears should be examined to determine blast cell types and percentages for cytomorphologic diagnosis of AML. Carefully selected areas of stained films presenting adequate cellular details should be used to count a minimum of 200 cells. In cases with borderline diagnosis, at least 500 cells should be counted. The identity of blast cells should be ascertained using appropriate cytochemical markers of neutrophilic, monocytic, and megakaryocytic differentiation. A blast cell count of > 30% in blood and/or bone marrow indicates AML or AUL, while a count of < 30% blasts in bone marrow suggests MDS, chronic myeloid leukemias, or even a leukemoid reaction. Myeloblasts, monoblasts, and megakaryoblasts comprise the blast cell count. The FAB approach with additional criteria should be used to distinguish AUL and various subtypes of AML (Ml to M7 and M6Er) and to differentiate MDS, MDS-ER, chronic myeloid leukemias, and leukemoid reaction. Bone marrow core biopsy and electron microscopy may be required to confirm the specific diagnosis. Immunophenotyping with lineage specific antibodies is in its infancy in veterinary medicine. Development of this technique is encouraged to establish an undisputed identity of blast cells. Validity of the proposed criteria needs to be substantiated in large prospective and retrospective studies. Similarly, clinical relevance of cytomorphologic, cytochemical, and immunophenotypic characterizations of AML in dogs and cats remains to be determined.  相似文献   

Membrana nictitans gland cyst in a dog     

Latimer CA  Wyman M  Szymanski C  Werling K 《Journal of the American Veterinary Medical Association》1983,183(9):1003-5, 965

A cyst involving the gland of the 3rd eyelid was removed from an 8-year-old dog. Clinically the circumscribed mass resembled a pigmented neoplasm. Histologically the cyst was multiloculated, with homogeneous eosinophilic periodic acid-Schiff-positive content. Melanin pigment was present in epithelial cells and cystic lumens. Protective functions of the 3rd eyelid were retained following excisional biopsy.  相似文献   

Extreme eosinophilia with disseminated eosinophilic granulomatous disease in a horse     

Latimer KS  Bounous DI  Colatos C  Carmichael KP  Howerth EW 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1996,25(1):23-26

Extreme eosinophilia with disseminated eosinophilic granulomatous disease is described in a 4-year-old Arabian mare. Clinical signs included weight loss, coughing, jugular distention, and ventral edema. Cutaneous lesions were not observed. Eosinophilic inflammation was observed in cytologic specimens from the respiratory tract, body cavities, and lymph nodes. At necropsy, a 20-cm diameter intrathoracic mass was observed. Smaller nodules were present in the lymph nodes, liver, spleen, adrenal glands, pancreas, and skeletal muscle. Histologically, these masses and nodules were characterized by infiltrates of eosinophils, macrophages, and multinucleated giant cells, reactive fibroplasia; and multifocal eosinophilic coagula. Microscopically, mild eosinophilic infiltrates were observed in sections of stomach, small intestine, colon, and pleura; however, gross lesions were not observed in these tissues at necropsy. The etiology of the extreme eosinophilia and disseminated eosinophilic granulomatous disease in this horse was not determined.  相似文献   

Molecular diagnosis of paramyxovirus infection in snakes using reverse transcriptase-polymerase chain reaction and complementary deoxyribonucleic acid:ribonucleic acid in situ hybridization.     

Matthew A Sand  Kenneth S Latimer  Christopher R Gregory  Pauline M Rakich  Elliott Jacobson  Kate E Pennick 《Journal of veterinary diagnostic investigation》2004,16(5):442-448

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Effects of hyperbaric oxygen therapy on uncomplicated incisional and open wound healing in dogs          下载免费PDF全文

Christian R. Latimer DVM  Cassie N. Lux DVM  DACVS‐SA  Sarah Roberts BS  DVM  Marti G. Drum DVM  PhD  DACVSMR  Cheryl Braswell DVM  DACVECC  Mee Ja M. Sula DVM  DACVP 《Veterinary surgery : VS》2018,47(6):827-836

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Corneal squamous cell carcinoma in a dog   总被引：1，自引：0，他引：1  

K S Latimer  R L Kaswan  J P Sundberg 《Journal of the American Veterinary Medical Association》1987,190(11):1430-1432

A squamous cell carcinoma in situ (corneal intraepithelial neoplasia) was diagnosed in the right eye of an 11-year-old female Golden Retriever. Papillomavirus antigen was not detected in the excised tissues, and the tumor was suspected to be a sequel to previous injury. The tumor was removed by lamellar keratectomy, and the surgical bed was subjected to double freeze-thaw cryotherapy. Tumor regrowth was not apparent approximately one year after treatment.  相似文献   

Renal carcinoma with osseous and pulmonary metastases in an Arabian gelding     

Rumbaugh ML  Latimer FG  Porthouse KR  Cho DY  LeBlanc CJ 《Equine veterinary journal》2003,35(1):107-109

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Pelger-Hu?t anomaly in cats     

K S Latimer  P M Rakich  D F Thompson 《Veterinary pathology》1985,22(4):370-374

Pelger-Hu?t anomaly was diagnosed in a young male cat on the basis of persistent nuclear hyposegmentation of blood granulocytes, absence of clinical disease or feline leukemia virus infection, and demonstration of genetic transmission of the anomaly. Neutrophils, eosinophils, basophils, and monocytes had significantly less nuclear segmentation when compared to similar leukocyte types from a control cat. On smears of bone marrow, megakaryocytes also appeared hyposegmented. A test mating with an unaffected queen produced a litter of five kittens (three males, two females). One male and one female kitten had the Pelger-Hu?t trait on examination of blood smears. Autosomal dominant transmission of this anomaly is suspected based on these findings.  相似文献