Comparison of serum osteocalcin concentration and alkaline phosphatase activity as indicators of bone activity in a foal following surgery          下载免费PDF全文

Lepage OM  Marcoux M 《The Canadian veterinary journal. La revue veterinaire canadienne》1991,32(4):239-240

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From shallow to deep waters: habitats used by larval lampreys (genus Petromyzon and Lampetra) over a western European basin     

Catherine Taverny  Isabelle Ortusi  Charles Roqueplo  Mario Lepage  Patrick Lambert 《Ecology of Freshwater Fish》2012,21(1):87-99

Abstract –  Habitat requirements of lamprey ammocoetes (Petromyzon marinus and Lampetra genus) were investigated, for the first time, from shallow to deep waters, at different spatial scales across the Gironde‐Dordogne continuum, thanks to a water suction dredge. Fish‐habitat relationships were assessed through two complementary statistical analyses: habitat‐use curves and habitat suitability models using the Boosted Regression Trees (BRT) technique. Analyses were performed on a small‐size data set that was characterised by the low prevalence of lamprey. The sea lamprey larvae occurred in deeper areas than their Lampetra genus counterparts. ‘Pools’ of 2 m’ depth and more were optimal habitats for the former species. Among the environmental variables retained to model lamprey occurrences, the mesohabitat (a categorical variable) was demonstrated to be highly influential, in terms of fine grain‐size substratum and vegetation cover. These preliminary results suggest that monitoring using the water suction dredge method may contribute to sea lamprey conservation.  相似文献   

Non-invasive assessment of equine bone: an update     

Lepage OM  Carstanjen B  Uebelhart D 《Veterinary journal (London, England : 1997)》2001,161(1):10-22

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General anaesthesia decreases osteocalcin plasma concentrations in horses     

Grafenau P  Eicher R  Uebelhart B  Tschudi P  Lepage OM 《Equine veterinary journal》1999,31(6):533-536

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Serum osteocalcin or bone Gla-protein, a biochemical marker for bone metabolism in horses: differences in serum levels with age.   总被引：2，自引：1，他引：1       下载免费PDF全文

O M Lepage  M Marcoux    A Tremblay 《Canadian journal of veterinary research》1990,54(2):223-226

Levels of alkaline phosphatase and osteocalcin or bone Gla-protein, a new marker of bone metabolism, were analyzed in blood samples of 50 clinically normal female Standardbred horses between four months and twenty years of age. Samples were collected in the morning before exercise. Serum osteocalcin was measured by radioimmunoassay using bovine antibodies. There was a significant inverse correlation between alkaline phosphatase, osteocalcin and the age of the animals up to 48 months. The decrease in osteocalcin levels in serum was very marked during the first 30 months of life. The mean osteocalcin concentration was respectively 47.3, 35.7 and 6.7 ng/mL for animals less than one year, between 1.5 and 2.5 years of age and older than 3.5 years. Alkaline phosphatase serum activity was higher in foals less than one year of age (means = 856 U/L) than in the two older groups (meansII = 339, meansIII = 351 U/L). We believe that osteocalcin is a useful parameter for the evaluation of bone metabolism in growing animals and in adults and is probably more specific than alkaline phosphatase.  相似文献   

Newsgathering     

Hirschberg E  Joseph Fu SC  Frisell WR  Farber E  Potter VR  Rusch HP  Saffiotti U  Shimkin MB  Brennan MJ  Nowell PC  Creech HJ  Taylor RM  Schabel FM  Frei E  Lepage GA  Weinhouse S  Hall TC 《Science (New York, N.Y.)》1972,176(4041):1288-1289

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CONGENITAL DISLOCATION OF THE DEEP DIGITAL FLEXOR TENDON ASSOCIATED WITH HYPOPLASIA OF THE SUSTENTACULUM TALI IN A THOROUGHBRED COLT     

Olivier M.  Lepage  DMV  MSc  Renée  Léveillé  DMV  Luc  Breton  DMV  MSc  Marcel  Marcoux  DMV  MSc 《Veterinary radiology & ultrasound》1995,36(5):384-386

An 11-month-old Thoroughbred colt was presented with a hard swelling at the proximal third of the right 4th metatarsal bone. A medial dislocation of the deep digital flexor tendon ( flexor digitorum profundus ) was also observed on the same leg. On the plantaroproximal-plantarodistal projection of the calcaneus, there was flattening and shortening of the sustentaculum tali. The smooth bony proliferation at the proximal third of the right 4th metatarus was compatible with a chronic splint bone fracture. This report describes a medial deep digital flexor dislocation associated with hypoplasia of the sustentaculum tali .  相似文献   

5 SPEED OF SOUND MEASUREMENTS OF THE THIRD METACARPAL BONE IN EXERCISING THOROUGHBRED RACEHORSES.     

B Carstanjen  OM Lepage  O Hars  P Langlois  H Amory  . 《Veterinary surgery : VS》2003,32(6):599-600

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Digital semiological anesthesia in horses: technique and elements of interpretation     

Piccot-Crézollet C  Casamatta JM  Lepage OM 《The Canadian veterinary journal. La revue veterinaire canadienne》2005,46(9):807-813

Digital semiological anesthesia in horses: Technique and elements of interpretation. Semiological anesthesia of the pes is used during examinations for lameness in horses. Recent research data on the distal digital, distal interphalangeal articular, and podotrochlear intrathecal nerve blocks indicate that they are less than specific when considered in isolation. They should be used in combination to localize pain in the pes. A positive response to anesthesia of the distal interphalangeal articulation could also indicate that the source of the pain was in the podotrochlear apparatus or the dorsal part of the sole. Podotrochlear anesthesia also anesthetizes the dorsal part of the sole and, later, the distal interphalangeal joint. Distal digital anesthesia affects a large palmar area of the hoof and extends dorsally. Overall, basic research provides little support for the practical uses of semiological blocks.  相似文献   

Serum osteocalcin and CTX-MMP concentration in young exercising thoroughbred racehorses     

Carstanjen B  Amory H  Sulon J  Hars O  Remy B  Langlois P  Lepage OM 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2005,52(3):114-120

Bone responds to exercise with changes in bone (re-)modelling, which might be monitored non-invasively with biochemical bone markers. The aim of this study was to evaluate the influence of exercise on serum osteocalcin and serum carboxy-terminal cross-linked telopeptide of type I collagen generated by matrix metalloproteinases (CTX-MMP) concentration in young racehorses. Seventy-one 2 to 4-year-old Thoroughbreds were included in this prospective infield study. Blood sampling was performed six times (i.e. six sampling cycles) during a 9-month period. Serum samples were analysed with commercial osteocalcin and CTX-MMP radioimmunoassays. Two-year-old racehorses had higher serum osteocalcin and CTX-MMP values than 3-year-old horses. Gender and training amplitude did not significantly influence serum osteocalcin and CTX-MMP values. Two-year-old horses showed an increase in osteocalcin values between cycles 2 and 3 and an increase in serum CTX-MMP values between cycles 1 and 2. Serum osteocalcin and CTX-MMP concentrations decreased between cycles 4 and 5, and 5 and 6. Three-year-old horses showed an increase in serum osteocalcin levels between cycles 3 and 4 and an increase in serum CTX-MMP concentrations between cycles 1 and 2, and 3 and 4. Serum osteocalcin levels decreased between cycles 5 and 6, whereas serum CTX-MMP levels decreased between cycles 4 and 5, and 5 and 6. Two- and three-year-old horses showed a decreased osteocalcin/CTX-MMP ratio between cycles 1 and 2. Moreover, 2-year-old horses showed an increase in the osteocalcin/CTX-MMP ratio between cycles 2 and 3. Sore shin formation did not significantly influence serum osteocalcin and CTX-MMP values. Serum osteocalcin and CTX-MMP are promising bone markers for monitoring exercise induced changes in equine bone metabolism.  相似文献