Effects of thromboxane synthetase inhibition on immune complex glomerulonephritis.   总被引：1，自引：0，他引：1  

S L Longhofer  D D Frisbie  H C Johnson  C A Culham  A J Cooley  K T Schultz  G F Grauer 《American journal of veterinary research》1991,52(3):480-487

To determine the role of thromboxane A2 in the pathogenesis of experimentally induced immune complex glomerulonephritis, 12 concanavalin A-immunized Beagles were infused with 1 mg of concanavalin A via each renal artery and treated twice daily for 8 days with either 30 mg of CGS 12970/kg, PO, a specific thromboxane synthetase inhibitor, or placebo. The effect of treatment was assessed by measuring endogenous creatinine clearance and urine protein and eicosanoid excretion, and by evaluating changes in glomerular morphometric characteristics. On postinfusion day 8, urine protein, thromboxane B2, and 11-dehydro-thromboxane B2 excretion, glomerular epithelial crescent formation, and glomerular cell proliferation in the CGS 12970-treated dogs were significantly decreased when compared with values in the placebo-treated group. Differences were not observed in endogenous creatinine clearance, urine prostaglandin E2 and 6-keto-prostaglandin F1 alpha excretion, or glomerular polymorphonuclear leukocyte infiltration between groups in this study. These findings suggest thromboxane A2 has a role in the development of immune complex glomerulonephritis and that thromboxane synthetase inhibition may be beneficial in attenuating some of the functional and histological changes associated with immune complex glomerulonephritis.  相似文献   

Unsaturated vitamin b(12) binding capacity in human and ruminant blood serum - a comparison of techniques including a new technique by high performance liquid chromatography     

Schultz WJ 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1987,16(3):67-72

A new technique by High Performance Liquid Chromatography (HPLC-gel permeation) shows promise as a tool to separate and quantitate the Unsaturated Vitamin B(12) Binding Capacity (UBSC) of the individual Vitamin B(12) binders in blood serum. This method, although not as rapid as protein-coated charcoal or cellulose separation techniques, is more applicable for use with large numbers of samples than gel filtration. The use of a radioactivity detector to monitor the eluant from the column permitted automation of the method. Comparable results for UBBC and for the UBBC of individual binders were obtained when samples were analyzed by gel filtration and HPLC. The HPLC method proved suitably precise and the recovery of added cyanocobalamin was acceptable. It is proposed that HPLC be the method of choice for measurement of the USBC of binders of Vitamin B(12) in blood serum.  相似文献   

Basic veterinary immunology: an overview.     

R D Schultz 《The Veterinary clinics of North America》1978,8(4):555-583

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Forum: A Framework for Resetting Wild Horse and Burro Management     

Barry L. Perryman  Gary McCuin  Brad W. Schultz 《Herpetological Monographs》2018,40(5):160-165

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Evaluation of an HMGA2 variant for pleiotropic effects on height and metabolic traits in ponies     

Elaine M. Norton  Felipe Avila  Nichol E. Schultz  James R. Mickelson  Ray J. Geor  Molly E. McCue 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):942-952

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Pathologic and immunohistochemical findings in an outbreak of systemic toxoplasmosis in a mob of red kangaroos     

Mariano Carossino  Rudy Bauer  Mark A. Mitchell  Charles O. Cummings  Anke C. Sthr  Nobuko Wakamatsu  Kimberly Harper  Ingeborg M. Langohr  Kendra Schultz  Maria S. Mitchell  Daniel K. Howe  Udeni B. R. Balasuriya 《Journal of veterinary diagnostic investigation》2021,33(3):554

Toxoplasma gondii is a zoonotic protozoan pathogen that infects many endothermic vertebrates, including humans; the domestic cat and other felids serve as the definitive host. Macropodids are considered highly susceptible to toxoplasmosis. Here, we describe the clinical, pathologic, and immunohistochemical findings of an outbreak of systemic toxoplasmosis in a mob of 11 red kangaroos (Macropus rufus), with high morbidity (73%) and mortality (100%) rates. Affected animals had either severe and rapidly deteriorating clinical conditions or sudden death, which was correlated with widespread necrotizing lesions in multiple organs and intralesional T. gondii organisms identified via MIC3-specific immunohistochemistry and confirmed by REP529-specific rtPCR. Quantification of parasites demonstrated the highest parasite density in pulmonary parenchyma compared with other tissues. Our study highlights the continued importance of this severe condition in Australian marsupials.  相似文献   

Measurement of Wildlife Value Orientations Among Diverse Audiences: A Multigroup Confirmatory Factor Analysis Among Hispanic and Non-Hispanic White Communities     

Loren D. Chase 《Human Dimensions of Wildlife》2016,21(2):127-143

Wildlife value orientations (WVOs) are increasingly being used to describe broad societal shifts that are altering the way people perceive wildlife. Concurrent with these shifts is a diversification of cultural heritages that complicate comparisons of WVOs across cultures. Yet, when measuring WVOs across cultures, differences in WVOs may be genuine variations between the populations, or may be artifacts of the measurement instrument. Therefore, there is a need to determine if various cultures interact with the instrument uniformly. Three multiple group confirmatory factor analyses (MGCFA) examined how ethnicity, acculturation, and language spoken are related to a WVO scale’s performance within Hispanic and non-Hispanic white communities. Results of each MGCFA support the cross-cultural stability of the WVO factor structure. Additional cross-cultural WVO research is needed to expand the construct and assist natural resource practitioners in understanding diverse constituencies, but conducting a MGCFA analysis should be a necessary precondition when comparing WVOs across cultures.  相似文献   

WSAVA Guidelines for the vaccination of dogs and cats          下载免费PDF全文

M. J. Day  M. C. Horzinek  R. D. Schultz  R. A. Squires 《The Journal of small animal practice》2016,57(1):4-8

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Increased risk of select glucocorticoid adverse events in dogs of higher body weight     

Loren S. Sri-Jayantha  Michael T. Doornink  Bridget K. Urie 《The Canadian veterinary journal. La revue veterinaire canadienne》2022,63(1):32

There are limited data on glucocorticoid treatment in dogs. The purpose of this study was to investigate whether dogs of higher body weight experienced more adverse events when receiving glucocorticoid therapy. Data pertaining to glucocorticoid therapy was abstracted from the records of 61 dogs that were prescribed glucocorticoids for treatment of immune-mediated thrombocytopenia or hemolytic anemia from 2014 to 2019. The odds of developing muscle atrophy and polyphagia during therapy were increased by 30% for each 5 kg of additional body weight. Almost half of the dogs (44.3%) fluctuated > 15% from baseline weight during therapy. Dogs whose body condition scored as above ideal were at increased risk (odds ratio = 4.2) for being diagnosed with urinary tract infection. Our findings suggest that standard linear glucocorticoid dosing may place higher body weight dogs at increased risk of developing adverse events. Accelerated glucocorticoid tapering and/or alternative dosing schemes in dogs with higher body weights may be prudent in efforts to improve tolerance and client compliance.  相似文献   

Resistance of the potato to latent mosaic     

E. S. Schultz  C. F. Clark  F. J. Stevenson  W. P. Raleigh 《American Journal of Potato Research》1937,14(4):124-127

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