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Pharmacokinetic evaluation of ceftiofur in serum, tissue chamber fluid and bronchial secretions from healthy beef-bred calves. 下载免费PDF全文
S L Halstead R D Walker J C Baker R E Holland G E Stein J G Hauptman 《Canadian journal of veterinary research》1992,56(4):269-274
Ceftiofur is a new broad spectrum cephalosporin marketed for the treatment of acute bovine respiratory disease. In this investigation ceftiofur was administered by intramuscular injection, at 24 h intervals, to healthy beef-bred calves for four days at dosages of 2.2 and 4.4 mg/kg of body weight, with 4 wk intervals between dosing regimens. Serum, tissue chamber fluid (TCF), and bronchial secretion (BS) concentrations of ceftiofur were measured by microbiological assay after the first and fourth dose of each dosing regimen. Peak serum concentrations (Cmax) of 8.8 micrograms/mL and 17.3 micrograms/mL were obtained approximately 2 h (Tmax), the time of mean peak concentration) after single injections of 2.2 mg/kg and 4.4 mg/kg, respectively. The Cmax was increased approximately twofold following multiple doses of 2.2 mg/kg (Cmax = 13.1 micrograms/mL) and 4.4 mg/kg (Cmax = 24.1 micrograms/mL). Ceftiofur accumulated slowly into TCF and peak concentrations were found to be approximately 14% of those observed in serum after the first dose and approximately 24% after multiple dosing. Concentrations of ceftiofur in BS were obtained rapidly with peak concentrations reaching 45% of the serum Cmax after the first dose. After multiple dosing the Cmax for BS was approximately 25% of the serum Cmax. This study found that both the 2.2 mg/kg and 4.4 mg/kg dosing regimens resulted in continuous serum, TCF and BS concentrations of ceftiofur that exceeded the minimal concentration required to inhibit the bacteria most frequently isolated from calves with acute bovine respiratory disease. 相似文献
3.
The effect of exploratory laparotomy on the serum and peritoneal haptoglobin concentrations of the pony. 总被引:1,自引:0,他引:1 下载免费PDF全文
Serum haptoglobin concentration was used as an indicator of the acute phase response in ponies undergoing exploratory laparotomy. Preoperative, 1 h intraoperative, 3 h, 6 h, 12 h and 24 h postoperative blood samples and 48 h postoperative peritoneal fluid samples were obtained for haptoglobin analysis. A spectrophotometric assay based on cyanmethemoglobin binding capacity (CyanBC) was used to determine haptoglobin concentrations. The preoperative reference range for serum haptoglobin concentrations in these ponies was 25-60 mg CyanBC/dL. Intraoperative and 3 h postoperative blood samples had decreased haptoglobin concentrations when compared to preoperative values. Serum haptoglobin concentrations began to rise by the 6 h postoperative sample and were generally elevated above preoperative values by the 24 h postoperative sample. Two of the ten ponies had mild signs of postoperative colic which were associated with twofold elevations in serum haptoglobin concentrations and fivefold elevations in peritoneal fluid haptoglobin concentrations. 相似文献
4.
盐分对碱茅种子发芽影响的机制 总被引:15,自引:0,他引:15
耐碱茅种子在盐(NaCl与Na2SO4)及干旱(PEG-6000模拟)胁迫下发芽及其机制的比较研究表明,种子发芽率随溶液渗透势的降低而下降,在等渗条件下三种溶液中的发芽率次序为Na2SO4>NaCl>PEG。NaCl与Na2SO4主要通过影响种子吸水量及对膜的毒性影响发芽,根据相关及通径分析结果,其机制为:(1)溶液渗透势及Na+浓度决定的种子吸水对发芽的直接正效应(通径系数0.73);(2)溶液Na+浓度引起的膜毒性对发芽的直接负效应(-0.51);(3)种子从溶液中吸收Na使种子吸水增加对发芽的间接正效应(0.30)及使膜毒性增大对发芽的间接负效应(-0.24)。 相似文献
5.
Baker RJ Valli VE 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1986,15(4):20-25
A review of the current literature available on feline serum proteins is presented. Early studies concentrated on comparative aspects of species variations in the electrophoretic pattern. The feline electrophoretogram was divided into five basic regions: albumin, alpha-1, alpha-2, beta and gamma. Different subdivisions of these areas were recognized depending on the support medium used. Current papers have compared the relative migration distances of each globulin peak to the migration of albumin. This "Rf" value enables reliable peak identification. To date, no data exists identifying the individual proteins responsible for the peaks in the alpha and beta regions. The only feline globulin to be studied is haptolobin; however its precise location on the electrophoretic strip was not identified. 相似文献
6.
A review of models of landscape change 总被引:23,自引:1,他引:22
William L. Baker 《Landscape Ecology》1989,2(2):111-133
Models of landscape change may serve a variety of purposes, from exploring the interaction of natural processes to evaluating proposed management treatments. These models can be categorized as either whole landscape models, distributional landscape models, or spatial landscape models, depending on the amount of detail included in the models. Distributional models, while widely used, exclude spatial detail important for most landscape ecological research. Spatial models require substantial data, now more readily available, via remote sensing, and more easily manipulated, in geographical information systems. In spite of these technical advances, spatial modelling is poorly developed, largely because landscape change itself is poorly understood.To facilitate further development of landscape models I suggest (1) empirical multivariate studies of landscape change, (2) modelling of individual landscape processes, (3) explicit study of the effect of model scale on model behavior, and (4) scaling-up results of studies, on smaller land areas, that have landscape relevance. 相似文献
7.
8.
C. Jacyn Baker Daniel P. Roberts Norton M. Mock Bruce D. Whitaker Kenneth L. Deahl Andrey A. Averyanov 《Physiological and Molecular Plant Pathology》2005,67(6):1322
The plant apoplast is an important mediator of communication between the cell cytoplasm and its surroundings. Plant cell suspensions offer a convenient model system to gain insight into apoplastic physiology. Here, we describe a novel phenomenon that took place when two naturally occurring phenolics were added together to either soybean or tobacco cell suspensions. Acetosyringone (AS) and/or hydroxyacetophenone (HAP), phenolics found in the extracellular/apoplast of tobacco cells, were added to soybean or tobacco cell suspensions undergoing an oxidative burst. Individually, AS appeared to be utilized as a typical peroxidase substrate to scavenge hydrogen peroxide, while HAP was utilized at a much lower rate. However, when added together the rate of utilization of both phenolics increased and surprisingly resulted in the production of hydrogen peroxide. We have further characterized this novel phenomenon in suspension cells. This study demonstrates that certain phenolics in plants can cause co-oxidation which, as in animals, could alter the structure and bioactivity of surrounding phenolics. 相似文献
9.
10.
Changes in the density and growth of brown trout (Salmo trutta) after intensive removal of sympatric Arctic charr (Salvelinus alpinus) in the sub‐Arctic lake Møkkelandsvatn,Norway 下载免费PDF全文
Martin A. Svenning Øyvind K. Hanssen J. Malcolm Elliott 《Ecology of Freshwater Fish》2015,24(4):591-599
This study tests the basic hypothesis that the removal of charr, Salvelinus alpinus (L.), would cause an increase in both the growth and density of a sympatric trout population, Salmo trutta L. The charr population was characterised by slow‐growing individuals, with a high proportion of mature fish, that is typical for so‐called overpopulated populations. A total of 31,000 charr was removed from the lake in the period 1990–1992, and the density of younger trout (1+, 2+), but not older trout (3+, 4+), increased. The growth of older trout (3+, 4+) increased, but the evidence for similar growth increases of younger trout (1+, 2+) was limited. From 1989 to 1990, the proportion of trout increased from 30 to only 40% of the total catch, but from 1991 to 1994, it was significantly higher (60–80%) than that of charr. Total trout biomass increased to a maximum in 1992 and then decreased so that the biomass of 1994 was nearly similar to that of 1989, that is before the start of the charr removal. Back‐calculated lengths of trout from otoliths showed that 2+ and 3+ trout caught in the pelagic were growing consistently faster over previous years than those caught in the littoral, while this was not the case for the 4+ fish. Therefore, the hypothesis was partially supported; the growth rate of trout increased (age groups 1+ to 4+), while the density of juvenile trout (1+, 2+), but not the older trout (3+, 4+), increased after the removal of charr. 相似文献