What Is Your Diagnosis?     

Nuñez-Ochoa L  Desnoyers M  Lecuyer M 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1993,22(4):122-123

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Phase transitions, critical phenomena, and instabilities     

Fleury PA 《Science (New York, N.Y.)》1981,211(4478):125-131

Transformations among many of the diverse states of matter arise from microscopic interactions involving very many (approximately 10(23)) constituent particles and result in dramatic changes in macroscopic properties. The values of some physical parameters vanish, while others approach infinity. These changes and their evolution are strikingly similar in systems as apparently different as liquids, magnets, superconductors, ferroelectrics, and liquid crystals, which suggests that there is an underlying unity to phase transition phenomena. The basis and extent of this unity are reviewed for many-body systems in equilibrium, and analogies with instability phenomena in systems far from equilibrium (such as lasers, fluid flows, and avalanche electronic devices) are pointed out.  相似文献   

Infectious behavior in a parasitoid     

Varaldi J  Fouillet P  Ravallec M  López-Ferber M  Boulétreau M  Fleury F 《Science (New York, N.Y.)》2003,302(5652):1930

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The MHC-binding and gp120-binding functions of CD4 are separable   总被引：18，自引：0，他引：18  

D Lamarre  A Ashkenazi  S Fleury  D H Smith  R P Sekaly  D J Capon 《Science (New York, N.Y.)》1989,245(4919):743-746

CD4 is a cell surface glycoprotein that is thought to interact with nonpolymorphic determinants of class II major histocompatibility (MHC) molecules. CD4 is also the receptor for the human immunodeficiency virus (HIV), binding with high affinity to the HIV-1 envelope glycoprotein, gp120. Homolog-scanning mutagenesis was used to identify CD4 regions that are important in class II MHC binding and to determine whether the gp120 and class II MHC binding sites of CD4 are related. Class II MHC binding was abolished by mutations in each of the first three immunoglobulin-like domains of CD4. The gp120 binding could be abolished without affecting class II MHC binding and vice versa, although at least one mutation examined reduced both functions significantly. These findings indicate that, while there may be overlap between the gp120 and class II MHC binding sites of CD4, these sites are distinct and can be separated. Thus it should be possible to design CD4 analogs that can block HIV infectivity but intrinsically lack the ability to affect the normal immune response by binding to class II MHC molecules.  相似文献   

First simultaneous isolation of influenza A virus and duck enteritis virus from commercial ducks in France     

H J Fleury  M Babin  J F Bonnici  J D Poveda  M Beyrie  A Vuillaume  D J Alexander 《The Veterinary record》1986,119(9):208-209

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Acral mutilation and analgesia in 13 French spaniels     

Paradis M  de Jaham C  Page N  Sauve F  Helie P 《Veterinary dermatology》2005,16(2):87-93

Acral mutilation and analgesia (AMA) is reported in 13 French spaniels in Canada. This newly recognized disorder shares striking similarities in clinical features and biopsy findings to the other acral mutilation syndromes or hereditary sensory neuropathies reported in German short-haired pointer dogs, English pointer dogs and English springer spaniels. Clinical signs are first noted between 3.5 and 12 months of age. Affected dogs lick, bite and severely self-mutilate their distal extremities resulting in ulcers with secondary bacterial infection. Auto-amputation of claws, digits and footpads occurs in severe cases. Single or multiple feet can be affected. Affected dogs walked on their severely mutilated feet without evidence of pain, lameness, or ataxia. The majority of the dogs were euthanized within days to months of diagnosis.  相似文献   

Clinical evaluation of a powder of quality elk velvet antler for the treatment of osteoarthrosis in dogs     

Moreau M  Dupuis J  Bonneau NH  Lécuyer M 《The Canadian veterinary journal. La revue veterinaire canadienne》2004,45(2):133-139

A powder of quality elk velvet antler (QEVA) was evaluated on client-owned dogs with osteoarthrosis (OA) in a clinical, double-blind, and placebo-controlled study. Thirteen dogs received a placebo for 30 days and then QEVA for 60 days. Twenty-five other dogs received QEVA for 60 days. Gait analysis measured with a force plate, clinical signs assessed by an orthopedic surgeon, performances in daily life activities and vitality assessed by the owners, and complete blood analyses were obtained at days 0, after 30 days of placebo and/or 60 days of QEVA. On placebo, the 13 dogs did not show significant improvement (P < 0.05); however, their gait, their performances in daily life activities, and their vitality were significantly improved on QEVA, based on changes in values exceeding those observed when placebo was administered. The 25 dogs on QEVA for 60 days showed similar improvements. No clinical changes were revealed on blood analyses. Administration of QEVA was effective in alleviating the condition in arthritic dogs.  相似文献   

Treatment of demodicosis in dogs: 2011 clinical practice guidelines     

Mueller RS  Bensignor E  Ferrer L  Holm B  Lemarie S  Paradis M  Shipstone MA 《Veterinary dermatology》2012,23(2):86-96, e20-1

Background and Objectives – These guidelines were written by an international group of specialists with the aim to provide veterinarians with current recommendations for the diagnosis and treatment of canine demodicosis. Methods – Published studies of the various treatment options were reviewed and summarized. Where evidence in form of published studies was not available, expert consensus formed the base of the recommendations. Results – Demodicosis can usually be diagnosed by deep skin scrapings or trichograms; in rare cases a skin biopsy may be needed for diagnosis. Immune suppression due to endoparasitism or malnutrition in young dogs and endocrine diseases, neoplasia and chemotherapy in older dogs are considered predisposing factors and should be diagnosed and treated to optimize the therapeutic outcome. Dogs with disease severity requiring parasiticidal therapy should not be bred. Secondary bacterial skin infections frequently complicate the disease and require topical and/or systemic antimicrobial therapy. There is good evidence for the efficacy of weekly amitraz rinses and daily oral macrocyclic lactones such as milbemycin oxime, ivermectin and moxidectin for the treatment of canine demodicosis. Weekly application of topical moxidectin can be useful in dogs with milder forms of the disease. There is some evidence for the efficacy of weekly or twice weekly subcutaneous or oral doramectin. Systemic macrocyclic lactones may cause neurological adverse effects in sensitive dogs, thus a gradual increase to the final therapeutic dose may be prudent (particularly in herding breeds). Treatment should be monitored with monthly skin scrapings and extended beyond clinical and microscopic cure to minimize recurrences. Editor’s Note – A brief review article by R. Mueller has been published: Evidence‐based treatment of canine demodicosis, Tierarztl Prax Ausg K Kleintiere Heimtiere 2011; 39: 419–24. This is not considered to constitute duplication of the article published here in Veterinary Dermatology.  相似文献   

Effects of bacterial lipopolysaccharide on thermoregulation in green anole lizards (Anolis carolinensis)     

Merchant M  Fleury L  Rutherford R  Paulissen M 《Veterinary immunology and immunopathology》2008,125(1-2):176-181

Fever is a non-specific host defense mechanism that comprises part of the innate immune response. Innate immune function is thought to be an important adaptive immunological response to infection because it occurs across a broad diversity of phyla. Some reptiles can mount a febrile response, despite the fact that their internal body temperatures (T(b)s) are, to some extent, controlled by the environmental temperatures in which they live. This study was undertaken to determine if LPS would induce fever in green anole lizards (Anolis carolinensis). Lizards were maintained in thermal gradients (22-45 degrees C) with a 12-h diurnal cycle. anoles were injected with LPS, pyrogen-free saline, or left untreated, and their T(b)s were recorded every 15min using internal cloacal probes. All lizards showed a diurnal periodicity in T(b) characterized by decreased temperatures during the scotophase (dark hours) and higher temperatures during the photophase (light phase). Anoles injected with LPS exhibited a hypothermic response, relative to untreated and saline-injected animals. The response varied from 2.1 to 4.6 degrees C lower than control lizards. The hypothermic response was initiated within 12-24h of LPS injection, and continued for 3 days after treatment. However, the anapyrexic response was observed primarily during scotophases, with photophase hypothermia observed only on the first day after LPS injection.  相似文献   

Sequential Extraction of Heavy Metals Found in MSW-Derived Compost     

Charles L. Bourque  Doreen LeBlanc  Manon Losier 《Compost science & utilization》2013,21(3):83-89

Compost standards usually contain maximum permissible levels of heavy metals. These almost always refer to “total” concentrations. However, more relevant to environmental impact due to compost usage are “leachable” concentrations. This study utilized a sequential extraction technique to evaluate availability of heavy metals present in an MSW-derived compost. Five fractions (A-E) were obtained, the result of progressively stronger leaching solutions. Profiles of fraction distributions varied drastically from metal to metal. Manganese and zinc had very significant amounts in fractions B and C, whereas copper and chromium were present almost entirely in fractions D and E, respectively. Comparisons with other leachate methods are offered.  相似文献