Clinical equine dysautonomia and autonomic neuron damage.     

D L Doxey  D M Pogson  E M Milne  J S Gilmour  H K Chisholm 《Research in veterinary science》1992,53(1):106-109

Damage to the neurons of selected autonomic ganglia was quantified in relation to the severity of the clinical signs shown in acute, subacute and chronic cases of dysautonomia (grass sickness). No connection between the clinical severity of acute or subacute dysautonomia and the amount of neuronal damage in the superior cervical, stellate and coeliaco-mesenteric ganglia could be demonstrated. However, a higher proportion of normal neurons were found in chronic cases. Jejunal submucosal neuronal damage was correlated with clinical severity but further work is required to confirm this finding and to establish how widespread the alimentary neuronal lesions are in dysautonomia of different severities.  相似文献   

Small intestine and small colon neuropathy in equine dysautonomia (grass sickness)     

D. L. Doxey  E. M. Milne  M. P. Woodman  J. S. Gilmour  H. K. Chisholm 《Veterinary research communications》1995,19(6):529-543

The number of neurons in the coeliacomesenteric ganglia and the myenteric and submucosal plexuses of the jejunum, ileum and small colon, and the pathological changes induced in them, were studied in various types of equine dysautonomia. In all forms of dysautonomia, severe and extensive neuron loss and damage occurred in the ileum. In acute and subacute dysautonomia, jejunal neuron loss and damage were severe, but in chronic cases significantly less loss or damage occurred. The damage followed the same pattern in the small colon but it was always less obvious than in the jejunum. The distribution of the damage was uniform within a segment of the intestine. In fatal cases of dysautonomia, the clinical severity and duration of illness seems, in most instances, to be related to the amount of neuronal disruption occurring in the jejunum. Severe disruption results in acute/subacute dysautonomia, while milder damage leads to the chronic form.No case of dysautonomia was encountered in which enteric neuron loss and damage occurred without significant neuronal disruption also occurring in the coeliacomesenteric ganglia.Ileal neuronal damage and loss are not invariably worse than that in the jejunum, and the possible reasons for this, together with the relationship between neuronal damage and possible causes of dysautonomia, are discussed.Abbreviations H&E haematoxylin and eosin Deceased. Formerly of the Moredun Research Institute, 408 Gilmerton Road, Edinburgh, EH17 7JH, UK  相似文献   

Citrullinaemia in Friesian calves     

Thornton RN  Gilmour ML  Rammel CA 《New Zealand veterinary journal》1991,39(4):145-146

Six Friesian calves from a pedigree herd died or were killed within 1 week of birth because of progressive central nervous disease in which the only consistent lesion was cerebral oedema. The cause was citrullinaemia, resulting from an autosomally inherited dysfunction of the urea cycle enzyme arginosuccinate synthetase. Citrullinaemia was diagnosed by demonstrating markedly elevated concentrations of citrulline in the blood of one calf and in the cerebral spinal fluid of another. One of two sires used in the herd was a heterozygous carrier of the disease. Heterozygocity was demonstrated using a polymerase chain reaction/restriction endonuclease test designed to detect the genetic mutation that causes citrullinaemia in cattle.  相似文献   

Pasteurella haemolytica infections in sheep     

Gilmour NJ 《The Veterinary quarterly》1980,2(4):191-198

Summary Pasteurella haemolytica causes two distinct disease syndromes in sheep. P. haemolytica biotype A causes septicaemia in young lambs and pneumonia in all ages of sheep. Biotype T produces an acute systemic disease affecting principally the upper alimentary tract and lungs in young adult sheep. The bacteriology, epidemiology and clinical and necropsy findings of the two diseases are described and the current situation regarding their experimental reproduction and immunology is reviewed.  相似文献   

Grass sickness: the paths of research     

J Gilmour 《Equine veterinary journal》1973,5(3):102-104

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The recovery of Pasteurella haemolytica from the tonsils of adult sheep   总被引：3，自引：0，他引：3  

N J Gilmour  D A Thompson  J Fraser 《Research in veterinary science》1974,17(3):413-414

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Computed tomographic appearance of canine thyroid tumours     

K. Deitz  L. Gilmour  V. Wilke  E. Riedesel 《The Journal of small animal practice》2014,55(6):323-329

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Characteristics of marine vibrios isolated from fish farm tanks     

A. Gilmour 《Aquaculture (Amsterdam, Netherlands)》1977,11(1):51-62

Twenty-five cultures of organisms (grouped into presumptive V. parahaemolyticus and V. alginolyticus strains) isolated from tank water used to farm marine fish were subjected to a series of preliminary tests for the identification of V. parahaemoliticus. None were positively identified as this organism. Consequently the isolates, following their characterization as Gram-negative, motile, oxidase-positive rods which were fermentative without the production of gas, together with ten named Vibrio spp., were subjected to various tests and the results were subjected to computer analysis.They were sorted into clusters and it was found that both the presumptive V. parahaemolyticus and V. alginolyticus groups were largely homogeneous. The analysis also showed that the presumptive V. parahaemolyticus strains and one presumptive V. alginolyticus strain were best classified as V. parahaemolyticus and that all but one of the presumptive V. alginolyticus strains would have been best classified as V. anguillarum. The named V. alginolyticus strains proved to be a heterogeneous group and were not closely related to any other group of organisms. The significance of the occurrence of Vibrio spp. in tank water used to farm marine fish, especially when this water is heated power station effluent, is discussed.  相似文献   

Pasteurella haemolytica infections in sheep     

N. J. L. Gilmour 《The Veterinary quarterly》2013,33(4):191-198

Summary

Pasteurella haemolytica causes two distinct disease syndromes in sheep. P. haemolytica biotype A causes septicaemia in young lambs and pneumonia in all ages of sheep. Biotype T produces an acute systemic disease affecting principally the upper alimentary tract and lungs in young adult sheep. The bacteriology, epidemiology and clinical and necropsy findings of the two diseases are described and the current situation regarding their experimental reproduction and immunology is reviewed.  相似文献   

Extinct 244Pu in ancient zircons   总被引：2，自引：0，他引：2  

Turner G  Harrison TM  Holland G  Mojzsis SJ  Gilmour J 《Science (New York, N.Y.)》2004,306(5693):89-91

We have found evidence, in the form of fissiogenic xenon isotopes, for in situ decay of 244Pu in individual 4.1- to 4.2-billion-year-old zircons from the Jack Hills region of Western Australia. Because of its short half-life, 82 million years, 244Pu was extinct within 600 million years of Earth's formation. Detrital zircons are the only known relics to have survived from this period, and a study of their Pu geochemistry will allow us to date ancient metamorphic events and determine the terrestrial Pu/U ratio for comparison with the solar ratio.  相似文献