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1.
Hamster sperm hyperactivation is enhanced by progesterone, and this progesterone-enhanced hyperactivation is suppressed by 17β-estradiol (17βE2) and γ-aminobutyric acid (GABA). Although it has been indicated that melatonin also enhances hyperactivation, it is unknown whether melatonin-enhanced hyperactivation is also suppressed by 17βE2 and GABA. In the present study, melatonin-enhanced hyperactivation was significantly suppressed by 17βE2 but not by GABA. Moreover, suppression of melatonin-enhanced hyperactivation by 17βE2 occurred through non-genomic regulation via the estrogen receptor (ER). These results suggest that enhancement of hyperactivation is regulated by melatonin and 17βE2 through non-genomic regulation. 相似文献
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Okada K Inoue A Okada M Murata Y Kakuta S Jigami T Kubo S Shiraishi H Eguchi K Motomura M Akiyama T Iwakura Y Higuchi O Yamanashi Y 《Science (New York, N.Y.)》2006,312(5781):1802-1805
The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK activation in cultured myotubes; in particular, the Dok-7 phosphotyrosine-binding domain and its target in MuSK are indispensable. Mice lacking Dok-7 formed neither acetylcholine receptor clusters nor neuromuscular synapses. Thus, Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK. 相似文献
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Fisheries Science - The changes in volatile compounds of living oysters Crassostrea gigas with shells under air-exposed storage for 7 days at 5 and 20 °C were investigated... 相似文献
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Tsujimura K Oyama T Katayama Y Muranaka M Bannai H Nemoto M Yamanaka T Kondo T Kato M Matsumura T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2011,73(12):1663-1667
A single non-synonymous nucleotide substitution of guanine (G) for adenine (A) at position 2254 in the viral DNA polymerase gene (encoded by open reading frame [ORF] 30) of equine herpesvirus type 1 (EHV-1) has been significantly associated with neuropathogenic potential in strains of this virus. To estimate the prevalence of EHV-1 strains with the neuropathogenic genotype (ORF30 G(2254)) in the Hidaka district--a major horse breeding area in Japan--we analyzed the ORF30 genomic region in cases of EHV-1 infection in this area during the years 2001-2010. Of the 113 cases analyzed, 3 (2.7%) were induced by ORF30 G(2254) strains. This prevalence is lower than those observed in the U.S.A. (10.8-19.4%), Argentina (7.4%), France (24%), and Germany (10.6%). 相似文献
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Large-scale microwave rapid pyrolysis of cellulosic materials has been investigated. Levoglucosan (1,6-anhydro--d-glucopyranose) was obtained from a larch log as the main anhydrosugar in 2.6% yield on the basis of dry wood weight. This yield would be much higher than that obtainable by conventional pyrolysis in the largescale reaction. Levoglucosenone (1,6-anhydro-3,4-dideoxy--D-glycero-hex-3-enopyranos-2-ulose) was found to be produced in one-quarter the amount of levoglucosan. Other anhydrosugars, such as mannosan (1,6-anhydro--D-mannopyranose), galactosan (1,6-anhydro--d-galactopyranose), and xylosan (1,4-anhydro--d-xylopyranose), were also confirmed to be produced as minor components depending on the proportion of the monosaccharide content in the larch. When microwave pyrolysis of used papers and filter papers was performed, the yields of levoglucosan were about 6% and 12%, respectively, suggesting that a higher content of cellulose gives a larger amount of levoglucosan. 相似文献
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Hiroe KON Gen L. TAKEI Masakatsu FUJINOKI Motoo SHINODA 《The Journal of reproduction and development》2014,60(3):202-209
It has been recently shown that mammalian spermatozoa were hyperactivated by steroids, amines and amino acids. In the
present study, we investigated whether hyperactivation of hamster sperm is regulated by progesterone (P) and γ-aminobutyric
acid (GABA). Although sperm hyperactivation was enhanced by P, GABA significantly suppressed P-enhanced hyperactivation in a
dose-dependent manner. Suppression of P-enhanced hyperactivation by GABA was significantly inhibited by an antagonist of the
GABAA receptor (bicuculline). Moreover, P bound to the sperm head, and this binding was decreased by GABA.
Because the concentrations of GABA and P change in association with the estrous cycle, these results suggest that GABA and P
competitively regulate the enhancement of hyperactivation through the GABAA receptor. 相似文献
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Tetsushi ONO Keiichi HISAEDA Yoichi INOUE Yutaka YAMADA Kenichi SHIBANO Ikki MITSUI Chizuka HENMI Yumi UNE Hideaki HAYASHI Sanggun ROH Masakatsu NOHARA Eiji UCHIDA Hajime NAGAHATA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(2):220
This study reports findings from the pathological examination of the forestomach of an 11-month-old Japanese Black steer with severely retarded growth (41% of expected weight) and chronic ruminal tympany. The ruminal papillae were weakly formed (0.3–0.5 cm long) and unevenly distributed. The cellulae and cristae reticuli were underdeveloped; the cristae were 0.4–0.7 cm in height and milky white. The keratinized layer in the stratified squamous epithelium was thickened. Ruminal pH was 5.25, and ruminal volatile fatty acid concentration was 11.7 mM. The steer’s severely retarded growth was considered to be caused by malnutrition due to developmental and functional failure of the forestomach. 相似文献
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Sugiura Yoshimasa Matsuura Yuta Katsuzaki Hirotaka Kakinuma Makoto Amano Hideomi Usui Masakatsu Tanaka Ryusuke Matsushita Teruo Miyata Masaaki 《Plant foods for human nutrition (Dordrecht, Netherlands)》2022,77(2):307-316
Plant Foods for Human Nutrition - The immunomodulating effect of phlorotannin was investigated in mice stimulated by ovalbumin. When analyzing the main components of phlorotannin concentrate (PTC)... 相似文献