Sonographic Evaluation of Liver Hemodynamic Indices in Overweight and Obese Dogs          下载免费PDF全文

A.F. Belotta  C.R. Teixeira  C.R. Padovani  S.C. Rahal  M.N. Mayer  M.J. Mamprim 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):181-187

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Revisiting the Roles of the University in Regional Economic Development: A Triangulation of Data          下载免费PDF全文

Heike Mayer 《Growth and change》2017,48(4):787-804

There is a general understanding that university plays a crucial role in regional development under the current age of knowledge economy. At the same time, we have observed a fair number of counter‐evidentiary studies, demonstrating several regions that do not thrive despite strong research universities or other patterns of development in the absence of research universities. However, they are based on case studies of individual universities or regions, and the findings currently cannot be generalized. Another set of studies that have challenged the effect of universities at the nationwide scale and demonstrated its disproportionately small impact of universities, but their scope is limited to spin‐offs, patents, and license activities. In this article, we propose to investigate this subject more systematically by triangulating three methods: 1) national‐scale regression models with Business Dynamics Statistics and National Establishment Time Series data, 2) a regional survey of IT and life science firms in four so‐called “second tier regions,” and 3) a microeconomic firm‐level analysis based on interviews with founders of technology intensive firms. Furthermore, we test the roles of university beyond those explicit, direct measures of spin‐offs and patents by analyzing the firm formation rate and firm growth rate at the regional level, as well as the sources of growth at the company level. All results point in the same direction: The research function of the university has been overstated, and the teaching function of the university has been underappreciated. These findings provide profound implications for the policy of regional development.  相似文献   

Endothelin‐1 Immunoreactivity and its Association with Intramedullary Hemorrhage and Myelomalacia in Naturally Occurring Disk Extrusion in Dogs          下载免费PDF全文

D. Mayer  A. Oevermann  T. Seuberlich  M. Vandevelde  A. Casanova‐Nakayama  S. Selimovic‐Hamza  F. Forterre  D. Henke 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(4):1099-1111

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Diagnostic ophthalmology. Bilateral preganglionic Horner's syndrome     

Grahn BH  Mayer M  Sandmeyer LS 《The Canadian veterinary journal. La revue veterinaire canadienne》2007,48(5):537-538

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Radiation therapy for pituitary tumors in the dog and cat          下载免费PDF全文

Mayer MN  Treuil PL 《The Canadian veterinary journal. La revue veterinaire canadienne》2007,48(3):316-318

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Retrospective evaluation of factors associated with emergency frequency and survival in equids presenting for emergency care (2019–2020): 3071 cases     

Jessica Bouton DVM  Langdon Fielding DVM  DACVECC  DACVSMR  Dustin Major DVM  DACVS  Emma Deane DVM  DACVECC  Jennifer Mayer VMD  DACVECC  Diane Rhodes DVM  DACVIM 《Journal of Veterinary Emergency and Critical Care》2023,33(5):598-605

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Studies on a fluorescent insect growth regulator metabolite complex with house-fly microsomal cytochrome P-450     

Richard T. Mayer  C.W. Fisher  J. Cocke  A.C. Bridges  J.K. Olson 《Pesticide biochemistry and physiology》1982,17(1):24-34

The fluorescent insect growth regulator 5[[[5-(dimethylamino)-1-naphthalenyl]amino]-1,3-benzodioxole (DNSAB) forms a metabolite complex with house-fly microsomal cytochrome P-450. Formation of the metabolite complex is dependent on the presence of NADPH and O₂; NADH supports the reaction at a reduced rate. The presence of antibodies to house-fly cytochrome c (P-450) reductase in reaction mixtures inhibits the complex formation, indicating that the reductase is necessary for transfer of electrons from NADPH to cytochrome P-450 to complete the reaction. In the oxidized form, the metabolite complex has a single absorbance maximum at 431 nm, whereas the reduced form has two absorbance maxima at 426 (major) and 455 nm (minor). The pH of the media affects the extinction of the 426- and 455-nm Soret bands; increased pH decreases the extinction of the 426-nm band and increases the extinction of 455-nm band. Formation of the DNSAB metabolite-cytochrome P-450 complex decreases the amount of CO-reactive cytochrome P-450 by 24%. The metabolite complex is not dissociable by treatment with ferricyanide or by using centrifugation techniques. Dissociation is accomplished by addition of DNSAB to the oxidized metabolite complex. Kinetic analysis of the complex formation gives apparent K_m and V_max values at 2.55 ± 1.0 μM and 1.1 ± 0.4 × 10^?2 ΔA min^?1 nmol^?1 cytochrome P-450, respectively. Addition of juvenile hormone [(E,E)-cis-methyl-10,11-epoxy-7-ethyl-3,11-dimethyl-2,6-tridecadienoate; JH] to the reaction medium competitively inhibits the formation of the metabolite complex giving an inhibition constant of 16 μM. DNSAB synergized the lethal effects of JH against Aedes aegypti larvae threefold; however, JH did not synergize DNSAB. These data suggest that DNSAB may acquire its hormonal qualities by complexing a species of cytochrome P-450 that metabolizes JH, thereby prolonging the in vivo lifetime of this hormone.  相似文献   

Pacemaker implantation in a ferret (Mustela putorius furo) with third-degree atrioventricular block.     

David Sanchez-Migallon Guzman  Joerg Mayer  Raffaele Melidone  Robert J McCarthy  Emily McCobb  Anoop Kavirayani  John E Rush 《Veterinary Clinics of North America: Exotic Animal Practice》2006,9(3):677-687

A 7.5-year-old castrated male ferret (Mustela putorius furo) was diagnosed with third-degree atrioventricular (AV) block. A monopolar epicardial pacemaker system was implanted, resulting in a regular, paced cardiac rhythm with third-degree AV block at 140 beats per minute. Over the next 2 months, the ferret developed anorexia, interstitial pneumonia, intermittent diarrhea, and hind-limb weakness and had a slow and progressive recovery. The ferret developed clinical signs of congestive heart failure 4 months after the surgery, resulting in its death 3 weeks later. Necropsy results attributed the death to cardiac failure due to extensive myocardial mineralization. To the authors' knowledge this is the first published report of surgical report of surgical pacemaker implantation in a ferret.  相似文献   

Agreement among surgical pathologists evaluating routine histologic sections of digits amputated from cats and dogs.     

Bruce K Wobeser  Beverly A Kidney  Barbara E Powers  Stephen J Withrow  Monique N Mayer  Maria T Spinato  Andrew L Allen 《Journal of veterinary diagnostic investigation》2007,19(4):439-443

Agreement among pathologists interpreting histologic specimens is an area of interest within human pathology, but little work in this area has been reported in the veterinary literature. Agreement among pathologists evaluating routine histologic sections of amputated digits from cats and dogs submitted to multiple diagnostic centers was examined. Histologic sections from surgical specimens were reviewed in a blinded fashion by two pathologists, and a comparison to the original diagnosis, as stated in the diagnostic report, was recorded. A total of 513 cases were reviewed, and complete agreement was reached in 409 (79.7%). Of the 104 instances of disagreement, 77 (74.0%) were considered to be of clinical significance. The diagnosis of keratoacanthoma was disagreed with in 19 of 21 diagnoses (90.4%). No other individual diagnosis was similarly disputed. The overall level of disagreement is large and is similar to that reported in human pathology and suggests that further study of this issue would be useful in veterinary pathology.  相似文献   

The combined effects of temperature and GnRHa treatment on the final stages of sexual maturation in Atlantic salmon (Salmo salar L.) females     

Vikingstad E  Andersson E  Norberg B  Mayer I  Klenke U  Zohar Y  Stefansson SO  Taranger GL 《Fish physiology and biochemistry》2008,34(3):289-298

Atlantic salmon (Salmo salar L.) females (2 SW), maturing for the first time, were reared under one of three temperature regimes (high: 14.3 ± 0.5°C; natural: 10.6 ± 1.0°C; and cold: 6.9 ± 1.0°C) in combination with one of two experimental treatments; an injection of GnRH analogue (GnRHa) contained in biodegradable microspheres, or a sham injection (microspheres only). The six experimental groups were then reared under simulated natural photoperiod for 4 weeks. Blood samples were drawn for analysis of plasma steroid levels and the fish were inspected for ovulation weekly. Batches of stripped eggs were incubated in triplicate incubators in raceways until the eyed stage. Treatment with GnRHa resulted in a substantial advancement and synchronization of ovulation at all temperatures, while exposure to cold water also appeared to advance ovulation slightly. While 75% (warm and cold) to 90% (natural) of GnRHa fish ovulated during the 4-week trial, only 30% of sham-treated females exposed to cold water, and none of the sham-treated fish held at higher temperatures, ovulated during this period. Survival rates of embryos to the eyed-stage were significantly higher for broodstock exposed to cold water. Plasma levels of testosterone (T), 17β-oestradiol (E₂), and 17α,20β-dihydroxy-4-pregnen-3-one (17,20βP) were all significantly affected by treatment with GnRHa and, to a lesser extent, temperature. The efficiency of GnRHa in counteracting the negative effects of high temperature on ovulation and the associated changes in circulating sex steroids suggest that temperature inhibition operates at least in part at the brain or pituitary.  相似文献