Toxic peripheral neuropathy with demyelination in Sprague-Dawley rats given CGS 21595--a 5-lipoxygenase inhibitor.     

D E Gunson  P S Sahota  W O Iverson  R Y Chau  G M McCormick  V M Traina 《Veterinary pathology》1992,29(2):145-151

Male and female Sprague-Dawley rats were given CGS 21595, a pro-drug that is almost immediately metabolized to CGS 19213, a naphthoquinone that acts as a 5-lipoxygenase inhibitor. The compound was administered by gavage to five groups of Sprague-Dawley rats (group Nos. 1, 5, n = 30; group Nos. 2-4, n = 20) at daily doses of 0, 50, 150, 500, or 1,000 mg/kg for 13 weeks. Rats in the higher dose groups had a reduced weight gain, but significant neurologic signs were not observed. A peripheral neuropathy consisting predominantly of myelin destruction in the spinal nerve roots and sciatic nerves in male rats treated with greater than or equal to 150 mg/kg CGS 21595 and in female rats treated with greater than or equal to 50 mg/kg CGS 21595 for 13 weeks. This lesion was not fully reversible after a recovery period of 4 weeks. Lesions consisted of ballooning of myelin sheaths, infiltration by macrophages, demyelination, and occasional areas of remyelination. Axons were generally preserved, and the brain and spinal cord were not affected. Male and female rats in all treatment groups had cytoplasmic hyaline droplets in the proximal renal tubules. This change was reversible after 4 weeks and was not associated with any other adverse effects on the kidney.  相似文献   

Ovine hereditary chondrodysplasia (spider syndrome) in Suffolk lambs   总被引：1，自引：0，他引：1  

PH PHILLIPS  CM BUNN  CE ANDERSON 《Australian veterinary journal》1993,70(2):73-74

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Strongyloides ransomi: detecting drug action on larvae in porcine tissue     

T B Stewart  W M Stone  O G Marti  W C McCormick 《American journal of veterinary research》1973,34(2):191-193

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Risk factors and prevalence of injuries in horses during various types of steeplechase races     

Stephen JO  White NA  McCormick WH  Cowles RR  Corley KT 《Journal of the American Veterinary Medical Association》2003,223(12):1788-1790

OBJECTIVE: To identify the types of injuries sustained by horses that competed in steeplechase races and determine the prevalence of and risk factors for those injuries. DESIGN: Prospective study. ANIMALS: 2,680 horses that competed in various types of steeplechase races from 1996 through 2000. PROCEDURE: Data regarding races; environment; equipment problems; the number of horses that entered, started, and finished races; the number of riders that fell; and the number of horses that were slowed or stopped by the rider, ran off the course, fell, and sustained injuries or physical abnormalities during races were collected on a standard form by the official veterinarian who attended each meet. Data from all meets were not recorded; however, in recorded meets, data from every race were reported. RESULTS: Data for 197 hurdle, 65 timber, 76 flat, and 8 mixed races were recorded. Nine (3.4/1,000 horses that started in races) horses died or were euthanatized, and 7 of those were associated with catastrophic musculoskeletal injury. Seven fractures were recorded. Four fractures involved forelimbs, 1 involved a hind limb, and 2 involved the cervical portion of the vertebral column. All horses with fractures were euthanatized. Deep or hard course conditions were associated with an increased risk of breakdown injuries. CONCLUSIONS AND CLINICAL RELEVANCE: Successful development and implementation of strategies to prevent injuries and death in horses in steeplechase races depend on a clear understanding of the types and prevalence of injuries involved and risk factors associated with those injuries.  相似文献   

Ability of induced corpora lutea to maintain pregnancy in beef cows   总被引：1，自引：0，他引：1  

Bridges PJ  Wright DJ  Buford WI  Ahmad N  Hernandez-Fonseca H  McCormick ML  Schrick FN  Dailey RA  Lewis PE  Inskeep EK 《Journal of animal science》2000,78(11):2942-2949

Experiments were conducted in beef cows without a primary CL, in which pregnancy had been maintained with exogenous progestogen. In preliminary trials, replacement CL induced ipsilateral to the embryo and after, rather than before, d 36 of pregnancy, maintained more pregnancies after withdrawal of exogenous progestogen (13/13 vs 2/6; P < 0.05). In Exp. 1, in cows with replacement CL induced by treatment with hCG on d 28 of pregnancy, treatment with flunixin meglumine on d 31 through 37 did not increase maintenance of pregnancy. Experiment 2 was conducted to evaluate directly the effects of concentrations of PGF2alpha and estradiol-17beta during d 31 through 35 of pregnancy on maintenance of pregnancy by replacement CL induced between d 28 and 31. In cows that maintained pregnancy while progestogen was provided, maintenance of pregnancy after withdrawal of exogenous progestogen tended to be greater with high (5/5) than with low (2/6; P < 0.10) concentrations of PGF2alpha and greater with low (6/7) than with high (2/6; P = 0.10) concentrations of estradiol-17beta. Secretion of progesterone by replacement CL was greater (P < 0.05) in cows with high than in those with low concentrations of PGF2, during d 31 through 35. Prostaglandin F2alpha may facilitate attachment of the bovine embryo (d 30 to 40) in a manner similar to that reported for implantation in other species. Cows that did not form CL in response to hCG on d 28 to 31 responded well when retreated after d 36. Again, maintenance of pregnancy was greater when replacement CL were induced after (9/9) rather than before d 36 (8/16; P < 0.05).  相似文献   

Contemporary issues of veterinary practice valuation and sale transactions.     

Larry F McCormick  Thomas McFerson  Lorraine Monheiser List 《Veterinary Clinics of North America: Small Animal Practice》2006,36(2):297-327, v-vi

This article comprises discussions on practices with little or no salable value, the determination and measurement of the value of a veterinary practice, the evolution of the small animal practice marketplace, the costs of selling a portion of a practice, lack of marketability discount, and C corporation issues.  相似文献   

The incidence and significance of excess acupuncture channel imbalance in the equine sport horse purchase examination, 1999–2004     

William H. McCormick VMD   《Journal of Equine Veterinary Science》2006,26(7):322-325

Prepurchase examinations are commonly used in the evaluation of sport horses. No data have been published concerning the use of traditional Chinese veterinary medical (TCVM) channel palpation with respect to the musculoskeletal status of sport horses for sale. The objective of the study is to summarize the results of channel evaluation when integrated with a Western examination in a series of prepurchase examinations. The prepurchase examination records of 235 sport horses were reviewed. The examined horses were presented as serviceable for the intended use. The examinations were performed by a single observer. The TCVM palpation examination and Western examinations, which often included radiography, infrared thermometry, diagnostic ultrasound, fiberoptic endoscopy, and diagnostic blood screens, were used to further evaluate the musculoskeletal system. The data were used to define the relationship between soundness, lameness, channel imbalance, and sale outcome. Over 6 years, 235 horses were examined. One hundred fifty-six (66%) were sound at their working gaits, and 79 (34%) had observable lameness. Two thirds of lame horses had palpable channel imbalance. Only a quarter of sound horses presented with palpable channel imbalance. Sound horses with no channel imbalance, that is, level channels, were most frequently sold, and lame horses with channel imbalance most frequently were not sold. Significantly more sound horses with level channels were sold as compared with sale outcome of sound horses with unbalanced channels. In conclusion, the TCVM channel examination is a useful component in the integrated prepurchase examination of sport horses.  相似文献   

Successful medical treatment of splenic abscesses in a horse     

CM STEEL  RA LONSDALE  JR BOLTON 《Australian veterinary journal》1998,76(8):541-542

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T-shaped malformation of the ventral colon in a Thoroughbred filly with colic     

GD Trope  CM Steel 《Australian veterinary journal》2010,88(8):322-325

A 4-month-old Thoroughbred filly presented for abdominal pain was diagnosed with a T-shaped malformation of the ventral colon at exploratory laparotomy. Following resection and anastomosis of the large colon, no further episodes of abdominal pain occurred during a 12-month follow-up. Acute dehiscence of the linea alba occurred as a complication of the initial laparotomy, but was successfully managed following additional surgical repair. T-shaped malformation of the ventral colon has not previously been reported and is considered a congenital malformation of mesocolon formation.  相似文献   

Comparative performance of straightbred and crossbred (F1) sires     

W E Neville  P R Utley  W C McCormick 《Journal of animal science》1985,60(3):632-643

The first phase of this study was the production of contemporary straightbred (SB) and reciprocal crossbred (F1) bulls by mating Angus (A) bulls to A and Santa Gertrudis (SG) cows and SG bulls to SG and A cows. Of the bulls produced during the 4-yr period, those used for breeding included 15 A, 15 SG, 8 A X SG and 8 SG X A. For 205-d weight and weight/day of age (W/DA) postweaning, A X SG had higher (P less than .05) performance than SG X A bulls and SG had higher (P less than .05) performance than A bulls. There was no difference (P greater than .05) between SG and A X SG for 205-d weight, postweaning average daily gain (ADG) or postweaning W/DA. Heterosis estimates were 5.2 (P less than .10), 9.9 (P less than .01) and 5.8% (P less than .01) for 205-d weight, postweaning ADG and W/DA, respectively. The second phase of this study was the comparison of SB and F1 bulls for reproductive and progeny performance by exposing them as yearlings to 25 Polled Hereford cows each. There were no differences (P greater than .05) among the four sire groups for proportion of cows exposed that had a calf, had a live calf or weaned a calf. Reproductive performance of sires also was evaluated in terms of number of days (NOD) from the beginning of the breeding period until calves were born. The NOD for calves by SG was greater (P less than .05) than for calves by A or F1 sires. Compared with calves from SB sires, the NOD for calves from A X SG and SG X A sires were 5.0 and 10.6 d (P less than .05) lower. Differences among sires within year and breeding of sire were significant for all preweaning traits and for W/DA postweaning of their progeny. The SG-sired calves were heavier (P less than .05) for birth and 205-d weight and had higher (P less than .05) postweaning ADG than A-sired calves. Mean performance of calves by reciprocal F1 sires did not deviate (P greater than .05) from the mean performance of those by SB sires. Calves by A X SG sires had higher (P less than .05) 205-d weight, postweaning ADG and W/DA than calves by SG X A sires. Results indicated that the primary genetic effects responsible for differences in performance of calves sired by F1 vs SB bulls were mean transmitted and mean heterotic effects.(ABSTRACT TRUNCATED AT 400 WORDS)  相似文献