Gonadotrophin-releasing hormone treatment in cattle: a meta-analysis of the effects on conception at the time of insemination   总被引：1，自引：0，他引：1  

WF MORGAN  IJ LEAN 《Australian veterinary journal》1993,70(6):205-209

SUMMARY Data from 40 trials described in 27 published papers were analysed by meta-analysis (pooling of data from numerous trials into a single analysis) to evaluate the effects of injecting gonadotrophin-releasing hormone (GnRH) In cattle at the time of Insemination on the risk of pregnancy. A total of 19 019 cows were involved In these studies. Analyses were stratified by trial and by the effects of dose of GnRH, type of GnRH and Insemination number (first, second or third and greater). Mantel-Haenszel analysis revealed that use of GnRH at Insemination significantly Increased the overall risk of pregnancy by 12.5% In treated cows (P < 0.05). However, Increases In risk of pregnancy were greatest (22.5%) when repeat breeders were treated. Results for use of GnRH or analogue at first service were similar, with Increased risks of pregnancy in treated cows of 5.2 and 8.0%, respectively. The risk of pregnancy tended to be higher (11.1%) when the dose of GnRH was 250 μg and when used at second Insemination (9.9%). The analyses demonstrated that while treatment at Insemination with GnRH and GnRH analogues Increased conception rates In dairy cattle, some variation In study results was attributable to the number of Inseminations after calving at which GnRH Is administered. Further efforts should be made to determine characteristics of populations of cows that have good fertility responses to GnRH and to determine the mode of action of GnRH in Increasing fertility. Meta-analysis proved to be a useful technique for evaluating the apparently conflicting results from trials and in evaluating the effect of factors such as Insemination number, dose and type of GnRH on responses to treatment.  相似文献   

Veterinary aspects of public health as part of a segmented curriculum--a progress report     

C R Dorn  D C Blenden  L A Selby  W F McCulloch 《Journal of the American Veterinary Medical Association》1972,161(11):1502-1507

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The university and the city   总被引：1，自引：0，他引：1  

W F McCulloch  C R Dorn  D C Blenden 《Journal of the American Veterinary Medical Association》1970,157(11):1771-1776

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Feline immunodeficiency virus     

WF ROBINSON  SE SHAW  R ALEXANDER  I ROBERTSON 《Australian veterinary journal》1990,67(8):278-280

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Evidence for substantial variations of atmospheric hydroxyl radicals in the past two decades     

Prinn RG  Huang J  Weiss RF  Cunnold DM  Fraser PJ  Simmonds PG  McCulloch A  Harth C  Salameh P  O'Doherty S  Wang RH  Porter L  Miller BR 《Science (New York, N.Y.)》2001,292(5523):1882-1888

The hydroxyl radical (OH) is the dominant oxidizing chemical in the atmosphere. It destroys most air pollutants and many gases involved in ozone depletion and the greenhouse effect. Global measurements of 1,1,1-trichloroethane (CH3CCl3, methyl chloroform) provide an accurate method for determining the global and hemispheric behavior of OH. Measurements show that CH3CCl3 levels rose steadily from 1978 to reach a maximum in 1992 and then decreased rapidly to levels in 2000 that were lower than the levels when measurements began in 1978. Analysis of these observations shows that global OH levels were growing between 1978 and 1988, but the growth rate was decreasing at a rate of 0.23 +/- 0.18% year(-2), so that OH levels began declining after 1988. Overall, the global average OH trend between 1978 and 2000 was -0.64 +/- 0.60% year(-1). These variations imply important and unexpected gaps in current understanding of the capability of the atmosphere to cleanse itself.  相似文献   

Preindustrial to modern interdecadal variability in coral reef pH   总被引：1，自引：0，他引：1  

Pelejero C  Calvo E  McCulloch MT  Marshall JF  Gagan MK  Lough JM  Opdyke BN 《Science (New York, N.Y.)》2005,309(5744):2204-2207

The oceans are becoming more acidic due to absorption of anthropogenic carbon dioxide from the atmosphere. The impact of ocean acidification on marine ecosystems is unclear, but it will likely depend on species adaptability and the rate of change of seawater pH relative to its natural variability. To constrain the natural variability in reef-water pH, we measured boron isotopic compositions in a approximately 300-year-old massive Porites coral from the southwestern Pacific. Large variations in pH are found over approximately 50-year cycles that covary with the Interdecadal Pacific Oscillation of ocean-atmosphere anomalies, suggesting that natural pH cycles can modulate the impact of ocean acidification on coral reef ecosystems.  相似文献   

Error assessment in decision-tree models applied to vegetation analysis     

Henry Lynn  Charles L. Mohler  Stephen D. DeGloria  Charles E. McCulloch 《Landscape Ecology》1995,10(6):323-335

Methods were developed to evaluate the performance of a decision-tree model used to predict landscape-level patterns of potential forest vegetation in central New York State. The model integrated environmental databases and knowledge on distribution of vegetation. Soil and terrain decision-tree variables were derived by processing state-wide soil geographic databases and digital terrain data. Variables used as model inputs were soil parent material, soil drainage, soil acidity, slope position, slope gradient, and slope azimuth. Landscapescale maps of potential vegetation were derived through sequential map overlay operations using a geographic information system (GIS). A verification sample of 276 field plots was analyzed to determine: (1) agreement between GIS-derived estimates of decision-tree variables and direct field measurements, (2) agreement between vegetation distributions predicted using GIS-derived estimates and using field observations, (3) effect of misclassification costs on prediction agreement, (4) influence of particular environmental variables on model predictions, and (5) misclassification rates of the decision-tree model. Results indicate that the prediction model was most sensitive to drainage and slope gradient, and that the imprecision of the input data led to a high frequency of incorrect predictions of vegetation. However, in many cases of misclassification the predicted vegetation was similar to that of the field plots so that the cost of errors was less than expected from the misclassification rate alone. Moreover, since common vegetation types were more accurately predicted than rare types, the model appears to be reasonably good at predicting vegetation for a randomly selected plot in the landscape. The error assessment methodology developed for this study provides a useful approach for determining the accuracy and sensitivity of landscape-scale environmental models, and indicates the need to develop appropriate field sampling procedures for verifying the predictions of such models.  相似文献   

Practice-based health assurance.     

G J Gunn  J S Simpson  I McCulloch  A G Masson  G F Swanson  A G Rafferty 《The Veterinary record》2001,149(14):430-431

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Human infections associated with waterborne Leptospires, and survival studies on serotype pomona   总被引：4，自引：0，他引：4  

R P Crawford  J M Heinemann  W F McCulloch  S L Diesch 《Journal of the American Veterinary Medical Association》1971,159(11):1477-1484

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Congenital hypothyroidism in Scottish Deerhound puppies     

WF ROBINSON  SE SHAW  B. STANLEY  RS WYBURN 《Australian veterinary journal》1988,65(12):386-389

Two Scottish Deerhound puppies had clinical and pathological features consistent with the diagnosis of congenital non-goitrous hypothyroidism. They were from separate litters, but were the progeny of the same sire and dam. The puppies were smaller, had shorter limbs and shorter, broader heads than their littermates. They also had histories of weakness, difficulty in walking and somnolence. A characteristic radiographic feature was the absence of epiphyseal growth centres. Both had depressed serum thyroxine (T4) levels and one did not respond to exogenous thyroid stimulating hormone. On necropsy, the thyroid glands were small, the follicles varied in size and contained little or no colloid. The adenohypophysis contained many cells with markedly vacuolated cytoplasm. It is suggested that the clinicopathological pattern is the result of a primary thyroid abnormality. Possible mechanisms include either primary thyroid hypoplasia or an unresponsiveness to thyroid stimulating hormone.  相似文献