Mucopolysaccharidosis in a domestic short-haired cat--a disease distinct from that seen in the Siamese cat.     

M E Haskins  P F Jezyk  R J Desnick  S K McDonough  D F Patterson 《Journal of the American Veterinary Medical Association》1979,175(4):384-387

A 10-month-old male domestic short-haired cat was examined because of progressive lameness, a broad face with depressed nasal bridge, small ears, corneal clouding, and multiple bone dysplasia. The cat excreted excessive amounts of glycosaminoglycan (a component of connective tissue) in its urine and had evidence of lysosomal storage of glycosaminoglycans in fibroblasts and neurons. Activity of alpha-L-iduronidase, a lysosomal enzyme involved in glycosaminoglycan degradation, was deficient in cultured fibroblasts and leukocytes. The mucopolysaccharidosis was distinct from that seen in Siamese cats in terms of the pathologic changes and the specific enzyme deficiency.  相似文献   

Carcinogen in rock fern (Chielanthes sieberi) from New Zealand and Australia     

BL SMITH  PP EMBLING  DR LAUREN  MP AGNEW  AD ROSS  PL GREENTREE 《Australian veterinary journal》1989,66(7):230-231

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Ganglioradiculitis (sensory neuronopathy) in a dog: clinical,morphologic, and immunohistochemical findings     

Porter B  Schatzberg S  McDonough S  Mertens D  de Lahunta A 《Veterinary pathology》2002,39(5):598-602

A 9-year-old Labrador Retriever was diagnosed with ganglioradiculitis (sensory neuronopathy). This idiopathic disease of mature dogs is characterized by a profound loss of sensory nerve function due to mononuclear inflammatory infiltration of peripheral ganglia and spinal nerve roots, with destruction of sensory neurons. Immunohistochemistry demonstrates that the infiltrating cells are primarily T lymphocytes and that immunoglobulins are not present on the cell membranes of affected neurons. The pathogenesis of ganglioradiculitis remains unclear, but the evidence points to a cell-mediated immune mechanism.  相似文献   

Polysaccharide storage myopathy in Morgan, Arabian, and Standardbred related horses and Welsh-cross ponies     

Valentine BA  McDonough SP  Chang YF  Vonderchek AJ 《Veterinary pathology》2000,37(2):193-196

Polysaccharide storage myopathy is an equine neuromuscular disorder characterized by accumulation of glycogen-related polysaccharide inclusions within skeletal muscle fibers. The pathologic criteria for diagnosis of this disorder are somewhat controversial; however, periodic acid-Schiff-positive, amylase-resistant inclusions are considered pathognomonic. Although these inclusions are most often found in affected horses related to the Quarter Horse, draft horse, and Warmblood breeds, this report describes these characteristic inclusions in muscle of five horses from nonrelated breeds (two Morgans, one Arabian, one Arabian x Thoroughbred, and one Standardbred) and two Welsh cross ponies. Affected horses had histories of recurrent exertional rhabdomyolysis, and one developed progressive weakness leading to increased recumbency. The affected ponies were part of an unrelated research project and had no apparent clinical signs.  相似文献   

Reduction and recovery of N-acetylglucosamine-1-phosphate transferase activity in the liver of sheep and rats after a single subcutaneous dose of tunicamycin     

PL STEWART  C MAY CSIRO  MV JAGO 《Australian veterinary journal》1998,76(4):287-288

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Equine hyperimmune serum protects mice against Clostridium difficile spore challenge     

Weiwei Yan  Kang-Soon Shin  Shih-Jon Wang  Hua Xiang  Thomas Divers  Sean McDonough  James Bowman  Anne Rowlands  Bruce Akey  Hussni Mohamed  Yung-Fu Chang 《Journal of veterinary science (Suw?n-si, Korea)》2014,15(2):249-258

Clostridium (C.) difficile is a common cause of nosocomial diarrhea in horses. Vancomycin and metronidazole have been used as standard treatments but are only moderately effective, which highlights the need for a novel alternative therapy. In the current study, we prepared antiserum of equine origin against both C. difficile toxins A and B as well as whole-cell bacteria. The toxin-neutralizing activities of the antibodies were evaluated in vitro and the prophylactic effects of in vivo passive immunotherapy were demonstrated using a conventional mouse model. The data demonstrated that immunized horses generated antibodies against both toxins A and B that possessed toxin-neutralizing activity. Additionally, mice treated with the antiserum lost less weight without any sign of illness and regained weight back to a normal range more rapidly compared to the control group when challenged orally with 10⁷ C. difficile spores 1 day after serum injection. These results indicate that intravenous delivery of hyperimmune serum can protect animals from C. difficile challenge in a dose-dependent manner. Hence, immunotherapy may be a promising prophylactic strategy for preventing C. difficile infection in horses.  相似文献   

BSE: lessons for Australia     

PL YOUNG 《Australian veterinary journal》1996,74(2):126-127

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In vivo rat assay for true protein digestibility: collaborative study     

F E McDonough  F H Steinke  G Sarwar  B O Eggum  R Bressani  P J Huth  W E Barbeau  G V Mitchell  J G Phillips 《Journal of the Association of Official Analytical Chemists》1990,73(5):801-805

Eight laboratories participated in a collaborative study to estimate precision of a standardized rat assay for determining true protein digestibility in selected animal, fish, and cereal products. Each of 7 test protein sources (casein, tuna fish, macaroni/cheese, pea protein concentrate, rolled oats, pinto beans, and nonfat dried milk) was fed as the sole source of protein at a 10% protein level in mixed diets. Each diet was fed to 2 replicate groups of 4 rats each for a 4-day acclimation period and a 5-day balance period. Mean digestibilities ranged from 98.6% for casein to 72.6% for pinto beans. Repeatability standard deviations ranged from 0.5 to 2.0%; the mean relative standard deviation for repeatability was 0.9% (range 0.5-2.8%). Reproducibility standard deviations ranged from 1.2 to 3.2%, and the mean relative standard deviation for reproducibility was 2.4% (range 1.3-4.4%). The method has been approved interim official first action for determining true protein digestibility in foods and ingredients.  相似文献   

Rutile-bearing refractory eclogites: missing link between continents and depleted mantle   总被引：9，自引：0，他引：9  

Rudnick RL  Barth M  Horn I  McDonough WF 《Science (New York, N.Y.)》2000,287(5451):278-281

A mass imbalance exists in Earth for Nb, Ta, and possibly Ti: continental crust and depleted mantle both have subchondritic Nb/Ta, Nb/La, and Ti/Zr, which requires the existence of an additional reservoir with superchondritic ratios, such as refractory eclogite produced by slab melting. Trace element compositions of minerals in xenolithic eclogites derived from cratonic lithospheric mantle show that rutile dominates the budget of Nb and Ta in the eclogites and imparts a superchondritic Nb/Ta, Nb/La, and Ti/Zr to the whole rocks. About 1 to 6 percent by weight of eclogite is required to solve the mass imbalance in the silicate Earth, and this reservoir must have an Nb concentration >/= 2 parts per million, Nb/La >/= 1.2, and Nb/Ta between 19 and 37-values that overlap those of the xenolithic eclogites. As the mass of eclogite in the continental lithosphere is significantly lower than this, much of this material may reside in the lower mantle, perhaps as deep as the core-mantle boundary.  相似文献   

Post-mortem findings in 54 cases of anesthetic associated death in cats from two spay-neuter programs in New York State     

Gerdin JA  Slater MR  Makolinski KV  Looney AL  Appel LD  Martin NM  McDonough SP 《Journal of Feline Medicine and Surgery》2011,13(12):959-966

Anesthetic-associated death (AAD) in cats is infrequent, but occurs far more frequently than in people. Post-mortem investigations of AAD in cats are uncommon, and results only sporadically published. Here we report the findings in 54 cases of AAD in cats. Significant gross and/or microscopic pre-existing disease, including pulmonary, cardiac, and systemic disease, was detected in 33% of cases. Pulmonary disease was most frequently diagnosed (24% of cases), and included cases of Aelurostrongylus abstrusus infection (9% of cases). Heart disease, including two cases of hypertrophic cardiomyopathy, was less frequent (11% of cases). Four percent died from surgical complications. No?significant gross or microscopic disease was detected in 63% of cases. Additional studies are needed to determine if these findings are representative of AAD in cats in other geographic areas or with access to veterinary care. This study demonstrates that post-mortem investigation of AADs is an important and worthwhile endeavor.  相似文献