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Hitoshi Fujimoto Gye-Hyeong Woo Reiko Morita Megu Itahashi Hirotoshi Akane Akiyoshi Nishikawa Makoto Shibutani 《Journal of toxicologic pathology》2013,26(2):119-129
Abstract: To determine effects of developmental exposure to brominated flame
retardants (BFRs), weak thyroid hormone disruptors, on white matter development, white
matter-specific global gene expression analysis was performed using microdissection
techniques and microarrays in male rats exposed maternally to decabromodiphenyl ether
(DBDE), one of the representative BFRs, at 10, 100 or 1000 ppm. Based on previous gene
expression profiles of developmental hypothyroidism and DBDE-exposed cases,
vimentin+ immature astrocytes and ret proto-oncogene (Ret)+
oligodendrocytes were immunohistochemically examined after developmental exposure to
representative BFRs, i.e., DBDE, 1,2,5,6,9,10-hexabromocyclododecane (HBCD; 100, 1000 or
10,000 ppm) and tetrabromobisphenol A (TBBPA; 100, 1000 or 10,000 ppm).
Vimentin+ and Ret+ cell populations increased at ≥ 100 ppm and ≥
10 ppm DBDE, respectively. Vimentin+ and Ret+ cells increased at ≥
1000 ppm HBCD, with no effect of TBBPA. The highest dose of DBDE and HBCD revealed subtle
fluctuations in serum thyroid-related hormone concentrations. Thus, DBDE and HBCD may
exert direct effects on glial cell development at ≥ middle doses. At high doses,
hypothyroidism may additionally be an inducing mechanism, although its contribution is
rather minor. 相似文献
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