Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS‐stimulated mouse macrophages     

Masami Tsukagoshi  Merisa Sirisopapong  Fu Namai  Minori Ishida  Supattra Okrathok  Suguru Shigemori  Tasuku Ogita  Takashi Sato  Sutisa Khempaka  Takeshi Shimosato 《Animal Science Journal》2020,91(1)

Probiotics are growing alternatives to antibiotics, and can contribute to the prevention and treatment of diseases and enhance livestock production. Lactobacillus (L.) ingluviei is a novel probiotic species with growth‐enhancement effects; however, this species remains poorly understood, and there have been (to our knowledge) no studies focusing on its immunological effects. Here, we isolated L. ingluviei C37 (LIC37) from chicken and evaluated the bacterium's immunomodulatory properties to explore its probiotic potential. Real‐time quantitative PCR and ELISA showed that in vitro exposure of inflammation‐stimulated mouse peritoneal macrophages to heat‐killed LIC37 led to decreases in tumor necrosis factor‐α and interleukin (IL)‐6 levels and an increase in IL‐10. These findings suggested that LIC37 exerts anti‐inflammatory effects by modulating cytokine profiles. This species may be an attractive probiotic bacterial strain for use in animal production.  相似文献