Valvular pulmonic stenosis in bullmastiffs     

R. Malik  D. B. Church  G. B. Hunt 《The Journal of small animal practice》1993,34(6):288-292

Six bullmastiffs with congenital heart disease were evaluated over a three-year period. In all the cases the problem was shown to be dysplasia of the pulmonary valve. Five cases were male, one was female. All dogs available to follow-up developed signs of cardiac decompensation. Bullmastiffs must be added to the list of breeds in which valvular pulmonic stenosis is encountered frequently.  相似文献   

Effects of heartworm and intestinal parasitic infections on hematology and peripheral lymph node cytology in louisiana dogs     

Gossett KA  Root CR  Cleghorn B  Church GE  Turk JR  Turk MA 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1987,16(4):97-101

Hookworm infected dogs had higher blood basophil counts than hookworm negative dogs. Dogs with occult heartworm infection (i.e., without microfilaremia) had higher blood neutrophil counts than heartworm negative dogs. The percentage of eosinophils in peripheral lymph nodes was higher in heartworm infected, microfilaremic dogs than in both occult infected dogs and heartworm negative dogs. Heartworm or intestinal parasitic infection had no other significant effects on hematologic parameters or peripheral lymph node cytology.  相似文献   

黄瓜全雌性基因连锁的AFLP和SCAR分子标记   总被引：32，自引：5，他引：32  

娄群峰  陈劲枫  Molly Jahn  陈龙正  耿红  罗向东 《园艺学报》2005,32(2):256-259

 本研究以全雌品种‘戴多星’自交系和弱雌品种‘北京截头’自交系为双亲杂交获得F₁ ,然后得到F₂ 性型分离群体, 利用分离群体分组分析法(Bulked Segregant Analysis, BSA) 构建全雌和弱雌两个基因池, 筛选了64对AFLP选择性引物EcoR I-NN +Mse I-NNN组合, 发现EcoR I-TG +Mse I-CAC引物组合在全雌基因池中扩增出一条分子量为234 bp的特异带。经F₂ 代单株验证, 该特异条带能在全雌单株中稳定出现。以MAP MAKER (Version 310) 软件分析, 该标记与全雌性位点的连锁距离在617 cM。命名该连锁标记为TG/CAC₂₃₄。将该特异条带回收、克隆、测序, 设计特异SCAR引物, 再对F₂ 代单株基因组DNA进行扩增, 仅在全雌单株中扩增出1条分子量为166 bp 的特异带, 表明已成功地将与黄瓜全雌性连锁的AFLP标记转化为操作简便、表现稳定的SCAR标记, 该标记命名为SA₁₆₆。  相似文献   

Evaluation of an HMGA2 variant for pleiotropic effects on height and metabolic traits in ponies     

Elaine M. Norton  Felipe Avila  Nichol E. Schultz  James R. Mickelson  Ray J. Geor  Molly E. McCue 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):942-952

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Keratoconjunctivitis sicca in dogs under primary veterinary care in the UK: an epidemiological study     

D. G. O'Neill  D. C. Brodbelt  A. Keddy  D. B. Church  R. F. Sanchez 《The Journal of small animal practice》2021,62(8):636-645

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The utility of a novel formulation of alfaxalone in a remote delivery system     

Molly Patterson  Nigel Caulkett  Peter Neuhaus  Kirby Pasloske  Kathreen Ruckstuhl 《Veterinary anaesthesia and analgesia》2021,48(4):537-540

ObjectiveTo quantify induction time, reliability, physiological effects, recovery quality and dart volume of a novel formulation of alfaxalone (40 mg mL^?1) used in combination with medetomidine and azaperone for the capture and handling of wild bighorn sheep.Study designProspective clinical study.AnimalsA total of 23 wild bighorn sheep (Ovis canadensis) in Sheep River Provincial Park, AB, Canada.MethodsFree-ranging bighorn sheep were immobilized using medetomidine, azaperone and alfaxalone delivered with a remote delivery system. Arterial blood was collected for measurement of blood gases, physiologic variables (temperature, heart and respiratory rates) were recorded and induction and recovery length and quality were scored.ResultsData from 20 animals were included. Administered dose rates were alfaxalone (0.99 ± 0.20 mg kg^?1; 40 mg mL^?1), azaperone (0.2 ± 0.04 mg kg^?1; 10 mg mL^?1) and medetomidine (0.16 ± 0.03 mg kg^?1; 30 mg mL^?1). The mean drug volume injected was 1.51 mL. The median (range) induction time was 7.7 (5.8–9.7) minutes, and recovery was qualitatively smooth.Conclusions and clinical relevanceAn increased concentration formulation of alfaxalone was administered in combination with medetomidine and azaperone, and resulted in appropriate anesthesia for the capture and handling of bighorn sheep. The dart volume was small, with potential for reducing capture-related morbidity.  相似文献   

Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study—A Randomized Clinical Trial          下载免费PDF全文

A. Boswood  J. Häggström  S.G. Gordon  G. Wess  R.L. Stepien  M.A. Oyama  B.W. Keene  J. Bonagura  K.A. MacDonald  M. Patteson  S. Smith  P.R. Fox  K. Sanderson  R. Woolley  V. Szatmári  P. Menaut  W.M. Church  M. L. O'Sullivan  J.‐P. Jaudon  J.‐G. Kresken  J. Rush  K.A. Barrett  S.L. Rosenthal  A.B. Saunders  I. Ljungvall  M. Deinert  E. Bomassi  A.H. Estrada  M.J. Fernandez Del Palacio  N.S. Moise  J.A. Abbott  Y. Fujii  A. Spier  M.W. Luethy  R.A. Santilli  M. Uechi  A. Tidholm  P. Watson 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(6):1765-1779

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Identification and validation of cold responsive microRNAs of <Emphasis Type="Italic">Hevea brasiliensis</Emphasis> using high throughput sequencing     

Linu Kuruvilla  MB Mohamed Sathik  Molly Thomas  Lisha.P Luke  Sumesh KV 《Journal of Crop Science and Biotechnology》2017,20(5):369-377

Cold stress is one of the major abiotic factors that influence the productivity and geographical distribution of many agriculturally important crops like Hevea brasiliensis. Cultivation of H. brasiliensis in India is being extended to northeastern regions, where low temperature during winter adversely affects its survival, growth, and productivity. Developing cold-tolerant genotypes is a primary requisite to maximize the productivity under such challenging environmental conditions. However, lack of methods for early evaluation of cold tolerance in the newly developed clones and the extensive time required for assessing their tolerance in the field are major constraints for clonal selection. The present study was initiated with an objective to identify and characterize cold stress responsive miRNAs from H. brasiliensis that show stronger association with cold tolerance. Next generation sequencing using Illumina HiSeq method revealed the expression of 21 and 29 conserved miRNA (from clone RRIM 600) families in cold-stressed and control samples, respectively. Forty-two novel miRNAs were identified from this study. Upon differential expression analysis, eight conserved miRNAs were found commonly expressed in both the samples. When expression analyses were performed subsequently with six selected miRNAs in two Hevea clones (viz. RRII 105 and RRIM 600), miR169 showed a strong association with cold tolerance. miRNAs such as miR482 and miR159 also exhibited association with cold tolerance. This study suggests the possibility of employing these miRNAs as markers for cold tolerance after validation in more number of genotypes with varying levels of cold tolerance.  相似文献   

Observed flow compensation associated with the MOC at 26.5 degrees N in the Atlantic   总被引：3，自引：0，他引：3  

Kanzow T  Cunningham SA  Rayner D  Hirschi JJ  Johns WE  Baringer MO  Bryden HL  Beal LM  Meinen CS  Marotzke J 《Science (New York, N.Y.)》2007,317(5840):938-941

The Atlantic meridional overturning circulation (MOC), which provides one-quarter of the global meridional heat transport, is composed of a number of separate flow components. How changes in the strength of each of those components may affect that of the others has been unclear because of a lack of adequate data. We continuously observed the MOC at 26.5 degrees N for 1 year using end-point measurements of density, bottom pressure, and ocean currents; cable measurements across the Straits of Florida; and wind stress. The different transport components largely compensate for each other, thus confirming the validity of our monitoring approach. The MOC varied over the period of observation by +/-5.7 x 10(6) cubic meters per second, with density-inferred and wind-driven transports contributing equally to it. We find evidence for depth-independent compensation for the wind-driven surface flow.  相似文献   

C. Clare Hinrichs and Thomas A. Lyson (eds.): Remaking the North American Food System: Strategies for Sustainability     

Molly D. Anderson 《Agriculture and Human Values》2009,26(3):251-252

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