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Farzaneh Assadian Gholamreza Nikbakht Siavash Niazi Reza Farahani Khaltabadi Monireh Jahantigh 《Veterinary research communications》2014,38(2):157-163
The eukaryotic expression plasmid of M2e-Hsp70 is a candidate M2e-based DNA vaccine. In order to evaluate the immunization potential of this construct, Specific Pathogen Free chickens were immunized either intramuscularly or orally. Mutant Salmonella typhimurium was used as carrier for oral delivery of the M2e-Hsp70 construct. M2e-specific humoral and cellular responses were tested by ELISA and Lymphocyte Proliferation Assay, respectively. Our results indicate that both humoral and cellular immune responses are conferred against M2e-Hsp70 plasmid in either of the intramuscular or oral routes of administration; however, these responses are significantly higher in intramuscular injection in contrast to oral administration. When it comes to mass vaccination of commercial chicken flocks oral administration is preferred due to the ease of application as well as its capability of eliciting mucosal, humoral and cellular immune responses; so measurements should be taken to improve the immunization potency of our orally delivered DNA vaccine. 相似文献
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Vahedi A Lotfinia I Sad RB Halimi M Baybordi H 《Pakistan journal of biological sciences: PJBS》2011,14(2):118-122
This study aims at assessing the relation between hypoalbuminemia and inhospital mortality in patients with acute stroke. In this cross-sectional study, a total of 112 consecutively admitted patients with first acute stroke in Ahvaz Jundishapur Hospital were enrolled. All patients hospitalized for 7-9 days or expired in this period of time. Admission hypoalbuminemia (serum albumin < 3.5 mg dL(-) as well as other prognostic factors were determined and compared between the two groups. One hundred and twelve patients, 74 males and 38 females with the mean age of 69.2 +/- 12.1 (66-79) years were enrolled. Twenty nine (25.9%) patients expired during the hospitalization. Totally, admission hypoal buminemia was present in 49 (43.8%) patients. 43% of the patients were Hypoalbuminemia. Frequency of patients with admission hypoalbuminemia and is chemic heart disease was significantly higher in the nonsurvivors (75.8-32.5%, p = 0.001; 34.5 vs. 16.9%, p = 0.047, respectively). The mean Glasgow Coma Scale score was significantly lower in the nonsurvivors (8.1 +/- 1.8 vs. 9.4 +/- 0.5, p = 0.003). These three parameters remained significant in multivariate analysis. Sex, age, history of hypertension, diabetes mellitus, hypertriglyceridemia, hypercholesterolemia, anemia, heart failure and smoking habit, admission atrial fibrillation, ethnicity and stroke type were comparable between the two groups. In conclusion, hypoalbuminemia is an independent predictor of inhospital mortality in patients with acute stroke. 相似文献
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Linguatula serrata is a cosmopolitan zoonotic parasite with its adult form occurring in the nasal and respiratory passages of canids as the
definitive hosts, while its immature stages localize in the mesenteric lymph nodes, liver, spleen, lungs, and, rarely, in
other organs, such as the ocular region of herbivorous intermediate hosts. Humans can behave as both intermediate and final
host and are infected by visceral and nasopharyngeal linguatulosis. Consumption of infected, improperly cooked viscera of
the intermediate hosts, including sheep, goats, cattle, camels, or other herbivores containing the larval stages of this parasite
is a potential source of infection of human beings with the nasopharyngeal form of linguatulosis. However, nasopharyngeal
secretions or feces of carnivores containing eggs of Linguatula are the main sources for infecting human beings with the visceral form of this infection. In the present study, the prevalence
of infection by nymphs of L. serrata in 101 camels in Yazd Province, central Iran, was estimated based on histopathological studies of samples from two, apparently
enlarged, mesenteric lymph nodes (MLN), together with one sample from a whitish pinpoint spot on the liver and spleen of each
animal. Thirteen camels (12.9%) were infected with the nymphal stage of L. serrata. Age and sex did not play a significant role in the prevalence of this parasitic infection. The number of parasites in each
MLN ranged from one to six larvae. In view of the consumption of raw or undercooked liver and visceral organs of camel by
humans of this region, the importance of careful inspection at slaughter needs to be emphasized. 相似文献
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Mohammad Hashemi Zahra Zakeri Ebrahim Eskandari-Nasab Mahdi Atabaki Seyed Mohammad Ebrahim Pourhosseini Mehdi Jahantigh Gholamreza Bahari Mohsen Taheri 《Iranian Biomedical Journal》2013,17(4):194-199
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. Methods: This case-control study was carried out on 100 patients with RA and 104 healthy subjects. The polymorphisms were determined using tetra amplification refractory mutation system-polymerase chain reaction assay. Results: The rs763361 (Gly307Ser) polymorphism increased the risk of RA in codominant, dominant and recessive-tested inheritance models (odds ratio [OR] = 3.18, 95% confidence intervals [95% CI] = 1.44-7.02, P = 0.004, CC vs. TT, and OR = 1.98, 95% CI = 1.10-3.57, P = 0.023, CC vs. CT-TT, and OR = 2.61, 95% CI = 1.26-5.37, P = 0.010, CC + CT vs. TT, respectively). In addition, the rs763361 T allele increased the risk of RA (OR = 2.06, 95% CI = 1.38-3.08, P<0.001). However, no significant difference was observed among the groups regarding CD226 rs727088 polymorphism (χ2 = 3.20, P = 0.202). Conclusions: Our finding showed that CD226 rs763361, but not rs727088, gene polymorphism increased the risk of RA in a sample of the Iranian population.Key Words: Rheumatoid arthritis (RA), CD226, Polymorphism 相似文献
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Khodakaram-Tafti A Khordadmehr M Ardiyan M 《Tropical animal health and production》2012,44(1):145-148
Gross and histopathologic lesions of the integumentary system were studied in 103 camels (Camelus dromedarius) slaughtered in Yazd Province of Iran. Dermatophilosis was diagnosed in 14 (13.6%) of the studied camels. Grossly, patchy
thickening of the skin with dark brown scabs or crusts were observed on the rump, flanks, abdomen, shoulders, and neck. A
heavy infestation with brown hard ticks was present on the lesions in almost all of the affected camels. On parasitology examination,
all the ticks were identified as Hyalomma spp. Histopathologic examination of the affected skins revealed prominent superficial thickening of the epidermis as orthokeratotic
and parakeratotic hyperkeratosis, degenerating neutrophils, serous fluid, and bacterial filaments. A lot of keratinaceous
debris associated with an exudate rich in neutrophils were seen as remarkable features of the lesions on the superficial epidermis.
Dermal inflammation was mild with infiltration of mononuclear inflammatory cells, particularly lymphocytes, around superficial
vessels. A Gram-positive filamentous organism which was divided into parallel rows of cocci was observed in the crusts by
Brown and Brenn Gram stain. This is the first report of the occurrence of dermatophilosis in the camels of Iran. With regard
to infestation of the lesions by Hyalomma spp., it seems that this tick may have an important role in the pathogenesis of dermatophilosis in the camels of this region. 相似文献
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In most parts of Iran, water scarcity has been intensifying and posing a threat to the sustainability of agricultural production. Wheat is the dominant crop and the largest irrigation water user in Iran; hence, understanding of the crop yield-water relations in wheat across the country is essential for a sustainable production. Based on a previously calibrated hydrologic model, we modeled irrigated and rainfed wheat yield (Y) and consumptive water use (ET) with uncertainty analysis at a subbasin level in Iran. Simulated Y and ET were used to calculate crop water productivity (CWP). The model was then used to analyze the impact of several stated policies to improve the agricultural system in Iran. These included: increasing the quantity of cereal production through more efficient use of land and water resources, improving activities related to soil moisture conservation and retention, and optimizing fertilizer application. Our analysis of the ratio of water use to internal renewable water resources revealed that 23 out of 30 provinces were using more than 40% of their water resources for agriculture. Twelve provinces reached a ratio of 100% and even greater, indicating severe water scarcity and groundwater resource depletion. An analysis of Y-CWP relationship showed that one unit increase in rainfed wheat yield resulted in a lesser additional water requirement than irrigated wheat, leading to a larger improvement in CWP. The inference is that a better water management in rainfed wheat, where yield is currently small, will lead to a larger marginal return in the consumed water. An assessment of improvement in soil available water capacity (AWC) showed that 18 out of 30 provinces are more certain to save water while increasing AWC through proper soil management practices. As wheat self-sufficiency is a desired national objective, we estimated the water requirement of the year 2020 (keeping all factors except population constant) to fulfill the wheat demand. The results showed that 88% of the additional wheat production would need to be produced in the water scarce provinces. Therefore, a strategic planning in the national agricultural production and food trade to ensure sustainable water use is needed. This study lays the basis for a systematic analysis of the potentials for improving regional and national water use efficiency. The methodology used in this research, could be applied to other water scarce countries for policy impact analysis and the adoption of a sustainable agricultural strategy. 相似文献
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