排序方式： 共有33条查询结果，搜索用时 15 毫秒
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Marilia Barreca Virginia Span Alessandra Montalbano Mercedes Cueto Ana R. Díaz Marrero Irem Deniz Ayegül Erdoan Lada Luki&#x; Bilela Corentin Moulin Elisabeth Taffin-de-Givenchy Filippo Spriano Giuseppe Perale Mohamed Mehiri Ana Rotter Olivier P. Thomas Paola Barraja Susana P. Gaudêncio Francesco Bertoni 《Marine drugs》2020,18(12)
The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use. 相似文献
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M. Khakbazan R.M. Mohr D.A. Derksen M.A. Monreal C.A. Grant R.P. Zentner A.P. Moulin D.L. McLaren R.B. Irvine C.N. Nagy 《Soil & Tillage Research》2009,104(1):30-38
In recent years alternative farming practices have received considerable attention from Canadian producers as a means to improve their net return from grain and oilseed production. Enhancing the efficiency of nitrogen fertilizer use, including a pulse crop in the rotation, reducing tillage and pesticide use are seen as viable options to reduce reliance on fossil fuel, lower input costs and decrease the risk of soil, air and water degradation. The objective of this study was to determine the effects of 16 alternative management practices for a 2-year spring wheat (Triticum aestivum L.)–field pea (Pisum sativum L.) rotation on economic returns, non-renewable energy use efficiency, and greenhouse gas emissions. The alternative management methods for wheat consisted of a factorial combination of high vs. low soil disturbance one pass seeding, four nitrogen (N) fertilizer rates (20 kg N ha?1, 40 kg N ha?1, 60 kg N ha?1 and 80 kg N ha?1), and recommended vs. reduced rates of in-crop herbicide application. Alternative management practices for field pea were high vs. low soil disturbance one pass seeding. The resulting 16 cropping systems were evaluated at the whole farm level based on 4 years (two rotation cycles) of data from field experiments conducted on two Orthic Black Chernozem soils (clay loam and loam textures) in Manitoba, Canada. The highest net returns on the clay loam soil were for the high disturbance system with 60 kg N ha?1 applied to wheat and the recommended rates of in-crop herbicides. The lowest application rate of N, together with low disturbance seeding, provided the highest economic returns on the loam soil. Energy use efficiency was highest for the lowest rate of N application for both tillage systems. The highest rate of N fertilizer and recommended rates of in-crop herbicide produced little additional yield response, lower net returns, and higher GHG emissions. An increase in N fertilizer application from 20 kg ha?1 to 80 kg ha?1 increased whole farm energy requirements by about 40%, while reducing herbicide rates had negligible effects on grain yields and total energy input. Overall, as N fertilizer rate increased, the associated GHG emissions were not offset by an increase in carbon retained in the above-ground crop biomass. Moderate to high soil test NO3-N levels at experimental sites reduced the potential for positive yield responses to N fertilizer in this study, thus minimizing the economic benefits derived from N fertilizer application. 相似文献
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Ba A Lesnoff M Poccard-Chapuis R Moulin CH 《Tropical animal health and production》2011,43(6):1101-1109
The herds of 95 families were monitored for 1 year in eight villages in the cotton-growing region of southern Mali. In 2006–2007,
reproduction performances were average, with 0.54 calvings/year per cow, and mortality was low. Herd numerical productivity
is not very high, less than 0.13/year, because of the high proportion of males kept for animal draught. Depending on the herd
size, the behaviour of the families differs, in terms of off-take and in-take of animals. Families that only have one or two
draught animals seek to increase their animal draught capacity, with a negative net off-take (−0.13/year). Families with two
to three cows have a very low net off-take (0.02/year), with culling of adult animals compensated by purchase. They therefore
capitalised this year, with an annual herd growth of 8%. Families with a very large herd (20 to 50 cows) take off more of
their stock, with a net off-take of 0.08/year (very few animal purchases) and make a stock growth of 5%. And finally, families
with an average-sized herd (6 to 19 cows) take off the whole of the year’s production, with a net off-take of 0.11/year and
a nil stock growth rate. The use of a demographic model made it possible to measure the sensitivity of the productivity rate
to the different demographic parameters. 相似文献
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Meret Elisabeth Ricklin Gutzwiller Hervé Rapha?l Moulin Andreas Zurbriggen Petra Roosje Artur Summerfield 《Veterinary research》2010,41(4)
Dendritic cells (DC) represent a heterogeneous cell family of major importance for innate immune responses against pathogens and antigen presentation during infection, cancer, allergy and autoimmunity. The aim of the present study was to characterize canine DC generated in vitro with respect to their phenotype, responsiveness to toll-like receptor (TLR) ligands and T-cell stimulatory capacity. DC were derived from monocytes (MoDC) and from bone marrow hematopoietic cells cultured with either Flt3-ligand (FL-BMDC) or with GM-CSF (GM-BMDC). All three methods generated cells with typical DC morphology that expressed CD1c, CD11c and CD14, similar to macrophages. However, CD40 was only found on DC, CD206 on MΦ and BMDC, but not on monocytes and MoDC. CD1c was not found on monocytes but on all in vitro differentiated cells. FL-BMDC and GM-BMDC were partially positive for CD4 and CD8. CD45RA was expressed on a subset of FL-BMDC but not on MoDC and GM-BMDC. MoDC and FL-DC responded well to TLR ligands including poly-IC (TLR2), Pam3Cys (TLR3), LPS (TLR4) and imiquimod (TLR7) by up-regulating MHC II and CD86. The generated DC and MΦ showed a stimulatory capacity for lymphocytes, which increased upon maturation with LPS. Taken together, our results are the basis for further characterization of canine DC subsets with respect to their role in inflammation and immune responses. 相似文献
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Investigation of the effect of Equivac® HeV Hendra virus vaccination on Thoroughbred racing performance 
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下载免费PDF全文 K Schemann EJ Annand PA Reid MF Lenz PC Thomson NK Dhand 《Australian veterinary journal》2018,96(4):132-141
Objective
To evaluate the effect of Equivac® HeV Hendra virus vaccine on Thoroughbred racing performance.Design
Retrospective pre‐post intervention study.Methods
Thoroughbreds with at least one start at one of six major south‐eastern Queensland race tracks between 1 July 2012 and 31 December 2016 and with starts in the 3‐month periods before and after Hendra virus vaccinations were identified. Piecewise linear mixed models compared the trends in ‘Timeform rating’ and ‘margin to winner’ before and after initial Hendra virus vaccination. Generalised linear mixed models similarly compared the odds of ‘winning’, ‘placing’ (1st–3rd) and ‘winning any prize money’. Timeform rating trends were also compared before and after the second and subsequent vaccinations.Results
Analysis of data from 4208 race starts by 755 horses revealed no significant difference in performance in the 3 months before versus 3 months after initial Hendra vaccination for Timeform rating (P = 0.32), ‘Margin to winner’ (P = 0.45), prize money won (P = 0.25), wins (P = 0.64) or placings (P = 0.77). Further analysis for Timeform rating for 7844 race starts by 928 horses failed to identify any significant change in Timeform rating trends before versus after the second and subsequent vaccinations (P = 0.16) or any evidence of a cumulative effect for the number of vaccines received (P = 0.22).Conclusion
No evidence of an effect of Hendra virus vaccination on racing performance was found. The findings allow owners, trainers, industry regulators and animal health authorities to make informed decisions about vaccination. 相似文献8.
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Giraud E Moulin L Vallenet D Barbe V Cytryn E Avarre JC Jaubert M Simon D Cartieaux F Prin Y Bena G Hannibal L Fardoux J Kojadinovic M Vuillet L Lajus A Cruveiller S Rouy Z Mangenot S Segurens B Dossat C Franck WL Chang WS Saunders E Bruce D Richardson P Normand P Dreyfus B Pignol D Stacey G Emerich D Verméglio A Médigue C Sadowsky M 《Science (New York, N.Y.)》2007,316(5829):1307-1312
Leguminous plants (such as peas and soybeans) and rhizobial soil bacteria are symbiotic partners that communicate through molecular signaling pathways, resulting in the formation of nodules on legume roots and occasionally stems that house nitrogen-fixing bacteria. Nodule formation has been assumed to be exclusively initiated by the binding of bacterial, host-specific lipochito-oligosaccharidic Nod factors, encoded by the nodABC genes, to kinase-like receptors of the plant. Here we show by complete genome sequencing of two symbiotic, photosynthetic, Bradyrhizobium strains, BTAi1 and ORS278, that canonical nodABC genes and typical lipochito-oligosaccharidic Nod factors are not required for symbiosis in some legumes. Mutational analyses indicated that these unique rhizobia use an alternative pathway to initiate symbioses, where a purine derivative may play a key role in triggering nodule formation. 相似文献