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Isabelle Ferreira Sheila C. Rahal Noeme S. Rocha Ana H. Gouveia† Thais P. Corrêa Yuri K. Carvalho Vanderlei S. Bagnato† 《Veterinary dermatology》2009,20(3):174-178
Photodynamic therapy (PDT) using a haematoporphyrin derivative (Photogem®, General Physics Institute and clustes Ltda) as photosensitizer and light emitting diodes (LEDs) as the light source was evaluated in 12 cats with cutaneous squamous cell carcinoma. Lesions were illuminated with LEDs, (300 J/cm for 30 min) 24 h after the administration of the photosensitizer. Clinical responses were classified as complete disappearance of the tumour with total re-epithelialization; partial response (a reduction greater than 50%); and no response (less than 50% reduction). Tumours localized to the pinna treated with one ( n = 3) or two ( n = 4) applications of PDT yielded no response. Highly invasive tumours of the nose and nasal planum also showed no response, after two treatments ( n = 2). A combination of PDT and surgery was performed in three cases. Two cats showed partial response and one complete response with one application of therapy 30 days after nasal surgery. Small and noninfiltrative lesions ( n = 3) of the nasal planum showed a PR with one application ( n = 2) and a CR with two applications ( n = 1). This study shows that PDT using Photogem® and LEDs can provide local control of low-grade feline squamous cell carcinoma. The addition of PDT to surgery in more invasive cases may help prevent recurrence. 相似文献
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Henrique de Souza Luche José Antonio Gonzalez da Silva Rafael Nornberg Emilio Ghisleni Arenhardt Vanderlei da Rosa Caetano Luciano Carlos da Maia Antonio Costa de Oliveira 《Journal of Crop Science and Biotechnology》2017,20(2):73-80
In wheat, the increase of yield and stability associated traits can be achieved by combining parents containing the stay-green trait and favorable alleles for grain yield. The aim of this work was to analyze the genetic dissimilarity between wheat lines from stay-green and synchronized maturation groups and elite cultivars. Moreover, to propose promising combinations seeking the selection of high-grain yield and high bread-making quality genotypes containing stay-green trait. The experiment was conducted in a randomized block design with three replications in 2003, 2004, and 2005, using sister-lines with the presence and absence of stay-green trait and elite cultivars. Genetic variability exists among wheat strains from the synchronized stay-green maturation group and elite cultivars. Genotypes of maturation group stay-green obtained an average performance superior to the synchronized group. Crosses between stay-green lines and the CEP 29 and BRS 177 cultivars are promising in the selection of genotypes carrying the stay-green trait with high yield and bread-making quality. 相似文献
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Raquel Yvonne Arantes Baccarin Marco Antonio Pereira Neimar Vanderlei Roncati Rafael Ramalho Corso Bergamaschi Stefano Carlo Filippo Hagen 《The Canadian veterinary journal. La revue veterinaire canadienne》2012,53(10):1079-1084
This study aimed to detect, by radiographic examination, the evolution of osteochondral lesions in the tarsocrural and femoropatellar joints of Lusitano foals. Within 1 month of age, 76.08% of foals had radiographic signs of osteochondrosis, but only 16.20% had lesions at 18 months. The radiographic signs resolved by 5 mo of age in most foals, but some cases that involved either joint, were not resolved until 12 mo of age. It is thought that the “age of no return” is 5 mo for the tarsocrural and 8 mo for the femoropatellar joint but this study demonstrated regression of osteochondral lesions in both joints of Lusitano foals up to 12 months of age. 相似文献
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Regulation of lysine metabolism and endosperm protein synthesis by the opaque-5 and opaque-7 maize mutations 总被引：3，自引：0，他引：3
Azevedo RA Lea PJ Damerval C Landry J Bellato CM Meinhardt LW Le Guilloux M Delhaye S Varisi VA Gaziola SA Gratão PL Toro AA 《Journal of agricultural and food chemistry》2004,52(15):4865-4871
Two high lysine maize endosperm mutations, opaque-5 (o5) and opaque-7 (o7), were biochemically characterized for endosperm protein synthesis and lysine metabolism in immature seeds. Albumins, globulins, and glutelins, which have a high content of lysine, were shown to be increased in the mutants, whereas zeins, which contain trace concentrations of lysine, were reduced in relation to the wild-type lines B77xB79+ and B37+. These alterations in the storage protein fraction distribution possibly explain the increased concentration of lysine in the two mutants. Using two-dimensional polyacrylamide gel electrophoresis of proteins of mature grains, variable amounts of zein polypeptides were detected and considerable differences were noted between the four lines studied. The analysis of the enzymes involved in lysine metabolism indicated that both mutants have reduced lysine catabolism when compared to their respective wild types, thus allowing more lysine to be available for storage protein synthesis. 相似文献
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Eder?Jorge?de?OliveiraEmail author Marcos?Deon?Vilela?de?Resende Vanderlei?da?Silva Santos Cláudia?Fortes?Ferreira Gilmara?Alvarenga?Fachardo?Oliveira Maiane?Suzarte?da?Silva Luciana?Alves?de?Oliveira Carlos?Ivan?Aguilar-Vildoso 《Euphytica》2012,187(2):263-276
The main objective of this study was to estimate the selection accuracy and to predict the genetic gain in cassava breeding using genomic selection methodologies. We evaluated 358 cassava genotypes for the following traits: shoot weight (SW), fresh root yield (FRY), starch fraction amylose content (AC), dry matter content (DMC), and starch yield (S-Y). Genotyping was performed using 390 single nucleotide polymorphisms (SNPs), which were used as covariates in the random regression-best linear unbiased prediction model for genomic selection. The heritability values detected by markers for the SW, FRY, AC, DMC, and S-Y traits were 0.25, 0.25, 0.03, 0.20, and 0.26, respectively. Because the low heritability detected for AC, this trait was eliminated from further analysis. Using only the most informative SNPs (118, 92, 56, and 97 SNPs for SW, FRY, DMC, and S-Y, respectively) we observed higher selection accuracy which were 0.83, 0.76, 0.67, and 0.77, respectively to SW, FRY, DMC, and S-Y. With these levels of accuracy and considering a selection cycle reduced by half the time, the theoretical gains with genomic selection compared to phenotypic selection for DMC, FRY, and SW would be 39.42 %, 56.90 %, and 73.96 %, respectively. These results indicate that in the cassava, genomic selection can substantially speed up selection cycles, thereby increasing gains per unit time. Although there are high expectations for incorporating this strategy into breeding programs, we still need to validate the model for other traits and evaluate whether the selection accuracy can be improved using more SNPs. 相似文献
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Fábio Gelape Faleiro Vagner Tibaldi Queiroz Uilson Vanderlei Lopes Cláudia Teixeira Guimarães José Luis Pires Milton Macoto Yamada Ioná Santos Araújo Messias Gonzaga Pereira Raymond Schnell Gonçalo Apolinário de Souza Filho Cláudia Fortes Ferreira Everaldo Gonçalves Barros Maurílio Alves Moreira 《Euphytica》2006,149(1-2):227-235
Molecular markers (RAPD, AFLP and microsatellites) were used to generate a linkage map and to identify QTLs associated to witches' broom (Crinipellis perniciosa) resistance in cacao (Theobroma cacao), using 82 individuals of an F2 population derived from the clones ICS-1 (susceptible) and Scavina-6 (resistant). Fifteen evaluations of the number of brooms have been carried out in six years (1997–2002). In order to increase the precision and accuracy in the measures of resistance, each F2 plant was cloned in three replications in a randomized block design with single-tree plots and evaluated over 2 years. Three hundred and forty-two markers were obtained, being 33 microsatellites, 77 AFLPs and 232 RAPDs. The distribution of the number of brooms in the F2 population was skewed to resistance, suggesting the involvement of major genes controlling resistance and the repeatability estimated for resistance was 44%. A strong putative QTL was detected as being related to witches' broom resistance. Associated to this QTL, the microsatellite mTcCIR35 explained 35.5% of the phenotypic variation in resistance. This marker is being used for marker-assisted selection in Scavina-6 progenies, including those selected in private plantations, as an auxiliary tool to the phenotypic selection. 相似文献
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Smoke invigoration versus inhibition of clouds over the Amazon 总被引：3，自引：0，他引：3
The effect of anthropogenic aerosols on clouds is one of the most important and least understood aspects of human-induced climate change. Small changes in the amount of cloud coverage can produce a climate forcing equivalent in magnitude and opposite in sign to that caused by anthropogenic greenhouse gases, and changes in cloud height can shift the effect of clouds from cooling to warming. Focusing on the Amazon, we show a smooth transition between two opposing effects of aerosols on clouds: the microphysical and the radiative. We show how a feedback between the optical properties of aerosols and the cloud fraction can modify the aerosol forcing, changing the total radiative energy and redistributing it over the atmospheric column. 相似文献