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Epstein-Barr virus: inhibition of replication by three new drugs 总被引：11，自引：0，他引：11
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and is associated with three human malignancies. Acyclovir [9-(2-hydroxyethoxymethyl)guanine], the first clinically useful drug effective against replication of EBV, is without effect against latent or persistent EBV infection. Three nucleoside analogs, E-5-(2-bromovinyl)-2'-deoxyuridine, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine, and 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil are potent inhibitors of EBV replication in vitro. Moreover, in contrast to the reversibility of viral inhibition by Acyclovir, these three drugs have prolonged effects in suppressing viral replication even after the drugs are removed from persistently infected cell cultures. 相似文献
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J. Chiarenzelli R. Scrudato K. Jensen T. Maloney M. Wunderlich J. Pagano J. Schneider 《Water, air, and soil pollution》1998,104(1-2):113-124
PCB mixtures in surface deposits composed of core sand and ash from an aluminum foundry are enriched (3.6–9.4%) in chlorine percentage relative to deeper horizons. The deeper materials closely match (R2 = 0.902–0.962) Aroclor 1248, the aroclor used on-site and recovered from the floor inside the foundry (R2 = 0.998). This similarity suggests the more deeply buried PCBs have been stable and immobile for a 20–40 yr period. Chlorine enrichment upward is interpreted as the result of volatilization of lower and orthochlorinated congeners from surficial materials during repeated water evaporation. These results suggest surficial deposits contaminated by PCBs may be a significant source of lower ortho-chlorinated PCB congeners to the atmosphere and that buried PCBs can remain unchanged for decades. Comparison with sediments contaminated with Aroclor 1248 and known to have undergone anaerobic microbial dechlorination, indicates that Aroclor 1248 can be transformed to PCB mixtures enriched or depleted in chlorine by environmental processes. 相似文献
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Effect of organic and mineral fertilizers on soil respiration and enzyme activities of two Mediterranean horticultural soils 总被引：1，自引：0，他引：1
The effects of municipal food waste compost addition and mineral fertilization on selected soil microbiological activities
were investigated during 3 years of reiterated treatments on two Mediterranean agricultural soils with different organic carbon
content. Compost at 15, 30 and 45 t ha−1 (dry matter), mineral (NPK) fertilizers and combined fertilizers with 15 t ha−1 of compost plus two reduced doses of mineral N were applied to both soils. At both sites, organic amendment increased soil
respiration, fluorescein diacetate hydrolysis, phosphatase and arylsulphatase activities. The differences in soil microbial
activities among treatments, found after 3 years of repeated treatments, were attributable to the variations of soil organic
C content and to the impact of soil tillage. Our results show that, in Mediterranean intensively cultivated agroecosystems,
annual organic amendments improve the microbial activity of soil and produce cumulative effects, suggesting the usefulness
of repeated high-rate compost applications. 相似文献
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Daniela Gargano Nunzia Scotti Alessandro Vezzi Alessandra Bilardi Giorgio Valle Stefania Grillo Salvatore Cozzolino Teodoro Cardi 《Genetic Resources and Crop Evolution》2012,59(3):419-430
The plastome sequence of the European cultivated potato, Solanum tuberosum subsp. tuberosum (tbr, GenBank accession no. DQ386163), was compared with that of S. bulbocastanum, a wild potato relative (blb, GenBank accession no. DQ347958), in order to characterize the degree and type of variability
in different genomic regions, and develop molecular markers relevant to genetics, breeding and biotechnology of potato. One
hundred forty-two and 251 PICs (Potentially Informative Characters) were found in coding and non-coding sequences (NCSs),
respectively. Further, while variation in coding regions was almost exclusively due to nucleotide substitutions, 25% of PICs
in NCSs of tbr and blb were due to indels, most of them mononucleotide or longer tandem repeats (micro and minisatellites).
Four intergenic regions were selected for further analyses in other 16 tuber-bearing Solanum species. The rps16-trnQ
UUG
gene spacer was found to be the most variable, forty-six PICs in this region distinguishing 18 haplotypes. Analysis of haplotype
relationships, based on variability in the four intergenic regions, confirmed that the most primitive species from Central
America were the most distant to S. tuberosum. Finally, polymorphic sites in the same regions were used to develop a set of CAPS (Cleaved Amplified Polymorphic Sequences)
markers for species/cytoplasm identification in Solanum spp. 相似文献
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Dual inoculation of a woody legume (Centrolobium tomentosum) with rhizobia and mycorrhizal fungi in south-eastern Brazil 总被引：1，自引：0，他引：1
The integration of N2 fixing trees into stable agroforestry systems in the tropics is being tested due to their ability to produce high biomass
N and P yields, when symbiotically associated with rhizobia and mycorrhizal fungi. The growth of Centrolobium tomentosum Guill. ex Benth, a native leguminous tree from the Brazilian Atlantic Forest, was assessed with dual inoculation of Rhizobium spp and mycorrhizal fungi under field conditions. Complete fertilization was compared to treatments of inoculation with selected
rhizobia strains BHICB-Ab1 or BHICB-Ab3, associated or not to arbuscular mycorrhizal (AM) fungi. The dual inoculation increased
the height and growth in relation to the plants treated with rhizobia alone. Plants inoculated with strain BHICB-Ab1 and arbuscular
mycorrhizal fungi (AMF) exhibited an increase of 56% dry matter over uninoculated control and nitrogen accumulation was greater
than with BHICB-Ab3 inoculated plants. Strain BHICB-Ab1 presented a synergetic relationship with mycorrhizal fungi since the
combined inoculation with BHICB-Ab1 enhanced plant height and dry weight more than single inoculation while the growth of
BHICB-Ab3 plants was not modified by AMF inoculation. Arbuscular mycorrhizal fungi enhanced plants survival and seemed to
favour the nodule occupation by rhizobia strains as compared to the non-mycorrhizal plants. Inoculation with selected rhizobia
and AMF improved the growth of C. tomentosum under field conditions.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
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Bone marrow aspiration smears from 15 dogs naturally infected with leishmania were evaluated. Three of the dogs showed no clinical signs, six had up to three clinical signs and six had more than three. The most common pathological features of the bone marrow were megakaryocytic dysplasia in 10 of the dogs, erythrophagocytosis in eight, erythroid dysplasia in two and emperipolesis in two. The megakaryocytic and erythroid dysplasia were probably related to an increased number of marrow macrophages producing high levels of tumour necrosis factor alpha and interferon gamma. Six of the dogs with clinical signs showed bone marrow dysplastic features and erythrophagocytosis, suggesting that leishmaniosis could be the unique cause of both conditions. 相似文献
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