Determination of red blood cell potassium content in horses with diarrhoea: A practical approach for therapy     

E. MUYLLE  J. NUYTTEN  C. VAN DEN HENDE  P. DEPREZ  K. VLAMINCK  W. OYAERT 《Equine veterinary journal》1984,16(5):450-452

The concentration of potassium in the red blood cells in 15 horses with severe diarrhoea was determined. The red blood cell potassium content (RBCK⁺) was low compared with levels obtained in normal horses. The decrease in the RBCK⁺ was used to evaluate the total body potassium deficit. This calculated amount was administered orally, following each RBCK⁺ determination. In those horses which recovered, RBCK⁺ content returned to normal levels. During treatment, refilling of the red blood cells with potassium occurred only gradually as long as the diarrhoea persisted. In each case, oral loading with the calculated dose resulted in an improvement of the general condition and no side effects were observed. The importance of using RBCK⁺ levels as a diagnostic and therapeutic parameter is discussed.  相似文献   

A Case of Bovine Linear Keratosis     

P. DEPREZ  H. DE COCK†  B. SUSTRONCK  E. MUYLLE  R. DUCATELLE† 《Veterinary dermatology》1995,6(1):45-49

Résumé— Cet article décrit un cas de nevus épidermique linéaire unilatéral chez un veau de six mois. Histologiquement, les lésions consistaient en une alternance de zones d'hiper et de parakératose avec une inflammation dermique distincte. Le diagnostic de nevus linéaire inflammatoire a été posé sur la base des lésions macro et microscopiques. [Deprez, P., De Coole, H., Sustronk, B., Muille, E., Ducatelle, R. A case of bovine linear keratosis (A propos d'un cas de kératose linéaire chez un bovin).
Resumen— En este artículo se describe un caso de nevos epidérmicos lineares unilaterales en un bo vino de seis meses de edad. Las lesiones histológicas consistian zonas donde se alternaba hiper i paraqueratosis, mientras que la dermis presentaba una marcada inflamación. Se diagnosticó un nevo epidérmico verrucoso linear e inflamatorio a partir de las lesiones clinicas e histopatológicas [A case of bovine linear keratosis (Un caso de queratosis linear bovina).
Abstract— This report describes a case of unilateral linear epidermal nevi in a 6-month-old bovine. Histologicalli, the lesions consisted of alternating areas of hiper- and parakeratosis with a distinct dermal inflammation. A diagnosis of inflammatori linear verrucous epidermal nevus was made based on the clinical and histopathological lesions.  相似文献   

TRANSRECTAL ULTRASONOGRAPHY OF THE LEFT ADRENAL GLAND IN HEALTHY HORSES     

INGE DURIE  GUNTHER VAN LOON  SIMON VERMEIRE  DOMINIQUE DE CLERCQ  KATLEEN VANSCHANDEVIJL  PIET DEPREZ 《Veterinary radiology & ultrasound》2010,51(5):540-544

Little information is available on medical imaging of the adrenal glands in horses. We investigated the feasibility of transrectal ultrasonography to characterize the normal equine adrenal gland. Transrectal ultrasonography was performed in 25 healthy horses using a 7.5 MHz linear array probe at a displayed depth of 8 cm. Transrectal ultrasonography of the right adrenal gland was not feasible. For the left adrenal gland, the left kidney, the abdominal aorta, the left renal artery, the left renal vein, and the cranial mesenteric artery were used as landmarks. The size of the left adrenal gland was variable, but it generally appeared as a long, flat structure with a hyperechoic medulla surrounded by a hypoechoic cortex. The most cranial part of the gland could not be delineated appropriately in 11 horses (44%). The mean (±SD) thickness of the gland and medulla was 0.66±0.15 cm (n=25) and 0.28±0.09 cm (n=25) near the caudal pole, 0.87±0.25 cm (n=14) and 0.40±0.18 cm (n=12) near the cranial pole, and 0.89±0.18 cm (n=25) and 0.36±0.13 cm (n=25) in the middle of the gland, respectively. The mean (±SD) length of the entire adrenal gland and of the medulla was 6.22±0.77 cm (n=14) and 5.45±0.71 cm (n=6), respectively. Transrectal ultrasonography allowed adequate visualization of the left adrenal gland in horses.  相似文献   

Effect of drug formulation and feeding on the pharmacokinetics of orally administered quinidine in the horse     

S. BOUCKAERT  J. VOORSPOELS  G. VANDENBOSSCHE  P. DEPREZ  J. P. REMON 《Journal of veterinary pharmacology and therapeutics》1994,17(4):275-278

Quinidine is the drug of choice for the treatment of cardiac arrhythmias in horses. The plasma concentrations vs. time profiles following oral administration of two formulations of quinidine sulphate, an oral solution and an oral suspension paste, were evaluated in nine horses. They received multiple administrations of the oral solution under fed and non-fed conditions and of the paste under non-fed conditions. A loading dose of 20 mg.kg_-1 and a maintenance dose of 10 mg.kg^-1 quinidine with dosing interval of 6 h were used. The relative bioavailability of the oral solution under fed conditions in comparison to the solution under non-fed conditions was 75.0 ± 10.2% for the loading dose and 97.18 ± 31.66% after the fourth dose. For the paste formulation the relative bioavailability values are not reported, as steady-state levels were not reached. There was a large variation in plasma quinidine levels when the paste formulation was administered. Feeding conditions had a significant influence on the C_max, values after administration of the loading dose. The T ^max values were not affected by food intake. It was concluded that an oral solution has to be preferred because of the variable drug bioavailability from the paste formulation and the poor acceptability of the paste by the horse.  相似文献   

Potassium concentration in equine red blood cells: Normal values and correlation with potassium levels in plasma     

E. MUYLLE  C. VAN DEN HENDE  J. NUYTTEN  P. DEPREZ  K. VLAMINCK  W. OYAERT 《Equine veterinary journal》1984,16(5):447-449

The concentration of potassium in plasma and in red blood cells was determined in 948 horses. The coefficient of correlation between the two parameters was low. In 436 of these horses, which were clinically healthy, the red blood cell potassium (RBCK⁺) levels did not fit within a normal distribution curve, but a bimodal distribution was observed with a section point at 90 mmol/litre. In 90 per cent of these normal horses, mean RBCK⁺ content was 97.5 mmol/litre. In the remaining 10 per cent, mean RBCK⁺ concentration was 93.8 mmol/litre. A subdivision into a ‘low potassium group’ and a ‘high potassium group’ was made. In 10 out of 15 horses in the ‘low potassium group’, bimonthly sampling over a period of one year showed that RBCK⁺ content remained low. In the remaining five horses an increase was observed.  相似文献   

Transaction Costs,Agglomeration Economies,and Industrial Location: A Comment     

PIET DE VRIES  GERT‐JAN HOSPERS 《Growth and change》2006,37(2):307-314

ABSTRACT This article comments on a recent contribution by Wood and Parr to Growth and Change. Wood and Parr apply the institutional–economic approach to agglomeration issues. After a sketch of the conceptual background, the present article discusses some concepts introduced by Wood and Parr, such as “transaction space” and the alleged relationship between space homogeneity and transaction cost. This is followed by critical remarks from the very same institutional–economic point of view. In the article, the conclusion is drawn that some limitations should be taken into account when applying the institutional perspective to agglomeration economics.  相似文献   

Multiple oral dosing of valacyclovir in horses and ponies     

B. GARRÉ  K. BAERT  H. NAUWYNCK  P. DEPREZ  P. DE BACKER  & S. CROUBELS 《Journal of veterinary pharmacology and therapeutics》2009,32(3):207-212

The aim of the current study was to investigate whether multiple oral dosing of valacyclovir could result in plasma concentrations exceeding the EC₅₀-value of acyclovir against equine herpesvirus 1 (EHV1) during the majority of the treatment period. Additionally, we wanted to determine the concentration of acyclovir in nasal mucus and cerebrospinal fluid (CSF). Valacyclovir was administered to four horses and two ponies, three times daily, at a dosage of 40 mg/kg, for four consecutive days. Blood was collected prior to each administration and 1 h after dosing. Nasal mucus samples and CSF were collected once during treatment; 1 h after the last administration. This dosage regimen resulted in plasma concentrations that were higher than the EC₅₀-value of 1.7 μg/mL, i.e. EC₅₀ of an isolate highly susceptible to acyclovir, for 80% of the treatment period; and higher than the EC₅₀-value of 3.0 μg/mL, i.e. EC₅₀ of an isolate less susceptible to acyclovir, for 60% of the treatment period. Concentration in nasal mucus samples and CSF was 0.36–1.17 μg/mL and 0.11–0.23 μg/mL, respectively. This study illustrates that multiple dosing of valacyclovir may result in a therapeutic benefit as plasma concentrations could be maintained above the EC₅₀-value of acyclovir against EHV1 for more than 50% of the treatment period. Acyclovir could be detected in both nasal mucus samples and CSF. However, these concentrations were lower than the EC₅₀.  相似文献   

POWER DOPPLER ASSESSMENT OF THE NEOVASCULARIZATION DURING UNCOMPLICATED FRACTURE HEALING OF LONG BONES IN DOGS AND CATS     

MARIJE RISSELADA  MARTIN KRAMER  JIMMY H. SAUNDERS  PIET VERLEYEN  HENRI VAN BREE 《Veterinary radiology & ultrasound》2006,47(3):301-306

The aims of this prospective study were to test the feasibility of assessing neovascularization with power Doppler ultrasonography and to investigate its usefulness to follow fracture healing of long bones in dogs and cats. A total of 51 patients (44 dogs and seven cats) were followed. Fracture types differed from simple to comminuted. Therapy ranged from external coaptation to plate osteosynthesis. Patients were followed with radiography, B-mode real time and power Doppler ultrasonography every 2-4 weeks until the fracture was healed. All fractures healed uneventfully. A semi-quantitative numerical score based on signal intensity, vessel area, and number of Doppler signals was assigned and the mean value was used to compare patients and examinations. Time postoperatively was divided into periods of 10 days. No Doppler signal was present during the first 10 days. The mean of the scores was highest between 11 and 20 days postoperatively and the median of the scores peaked between 21 and 30 days. A gradual decrease was seen thereafter. The mean of the scores was zero at 71-80 days and the median at 51-0 days postoperatively for the grouped results. In all positive power Doppler examinations, signals were present in and close to the callus. In seven patients (five dogs and two cats) signals were also present in the peripheral soft tissues in one of the follow up examinations. The normal healing process of fractured bones can be visualized using power Doppler ultrasonography and follows a distinctive time-dependent pattern.  相似文献