Carcinogen in rock fern (Chielanthes sieberi) from New Zealand and Australia     

BL SMITH  PP EMBLING  DR LAUREN  MP AGNEW  AD ROSS  PL GREENTREE 《Australian veterinary journal》1989,66(7):230-231

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Reduction and recovery of N-acetylglucosamine-1-phosphate transferase activity in the liver of sheep and rats after a single subcutaneous dose of tunicamycin     

PL STEWART  C MAY CSIRO  MV JAGO 《Australian veterinary journal》1998,76(4):287-288

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THE SOCIETY OF AMERICAN BACTERIOLOGISTS. III     

Hitchens AP 《Science (New York, N.Y.)》1913,38(978):451-454

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Caudal lumbar vertebral fractures in California Quarter Horse and Thoroughbred racehorses          下载免费PDF全文

E. M. Collar  R. Zavodovskaya  M. Spriet  P. L. Hitchens  T. Wisner  F. A. Uzal  S. M. Stover 《Equine veterinary journal》2015,47(5):573-579

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BSE: lessons for Australia     

PL YOUNG 《Australian veterinary journal》1996,74(2):126-127

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BIOLOGICAL ABSTRACTS     

Osborn H  Hitchens AP  Hooker DR  Kofoid CA  Lewis IF  Ball ED  McClung CE  Schramm JR  Woods AF  Greenman MJ 《Science (New York, N.Y.)》1924,60(1561):485-489

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THE SOCIETY OF AMERICAN BACTERIOLOGISTS. II     

Hitchens AP 《Science (New York, N.Y.)》1913,38(977):409-416

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Pharmacokinetic and pharmacodynamic modelling of intravenous,intramuscular and subcutaneous buprenorphine in conscious cats     

Paulo VM Steagall  Ludovic Pelligand  Tatiana Giordano  Christophe Auberger  John W Sear  Stelio PL Luna  Polly M Taylor 《Veterinary anaesthesia and analgesia》2013,40(1):83-95

ObjectiveTo describe simultaneous pharmacokinetics (PK) and thermal antinociception after intravenous (IV), intramuscular (IM) and subcutaneous (SC) buprenorphine in cats.Study designRandomized, prospective, blinded, three period crossover experiment.AnimalsSix healthy adult cats weighing 4.1 ± 0.5 kg.MethodsBuprenorphine (0.02 mg kg^?1) was administered IV, IM or SC. Thermal threshold (TT) testing and blood collection were conducted simultaneously at baseline and at predetermined time points up to 24 hours after administration. Buprenorphine plasma concentrations were determined by liquid chromatography tandem mass spectrometry. TT was analyzed using anova (p < 0.05). A pharmacokinetic-pharmacodynamic (PK-PD) model of the IV data was described using a model combining biophase equilibration and receptor association-dissociation kinetics.ResultsTT increased above baseline from 15 to 480 minutes and at 30 and 60 minutes after IV and IM administration, respectively (p < 0.05). Maximum increase in TT (mean ± SD) was 9.3 ± 4.9 °C at 60 minutes (IV), 4.6 ± 2.8 °C at 45 minutes (IM) and 1.9 ± 1.9 °C at 60 minutes (SC). TT was significantly higher at 15, 60, 120 and 180 minutes, and at 15, 30, 45, 60 and 120 minutes after IV administration compared to IM and SC, respectively. IV and IM buprenorphine concentration-time data decreased curvilinearly. SC PK could not be modeled due to erratic absorption and disposition. IV buprenorphine disposition was similar to published data. The PK-PD model showed an onset delay mainly attributable to slow biophase equilibration (t_1/2k_e0 = 47.4 minutes) and receptor binding (k_on = 0.011 mL ng^?1 minute^?1). Persistence of thermal antinociception was due to slow receptor dissociation (t_1/2k_off = 18.2 minutes).Conclusions and clinical relevanceIV and IM data followed classical disposition and elimination in most cats. Plasma concentrations after IV administration were associated with antinociceptive effect in a PK-PD model including negative hysteresis. At the doses administered, the IV route should be preferred over the IM and SC routes when buprenorphine is administered to cats.  相似文献   

Prevalence,radiographic resolution and outcomes of slab fractures of the third and central tarsal bones in juvenile Thoroughbred horses     

CM Steel  VL Collins  SR Hance  AR Adkins  PL Hitchens 《Australian veterinary journal》2019,97(4):108-115

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Micromechanical "Trampoline" magnetometers for use in large pulsed magnetic fields     

V Aksyuk  FF Balakirev  GS Boebinger  PL Gammel  RC Haddon  DJ Bishop 《Science (New York, N.Y.)》1998,280(5364):720-722

A silicon micromechanical magnetometer was constructed and successfully used in 60-tesla pulsed magnetic fields of less than 100-millisecond duration. The device is small, inexpensive to fabricate, and easy to use. It features a fast mechanical response (up to 50,000 hertz) and extremely high sensitivity yet is relatively robust against electrical and mechanical noise. Quantum oscillations in the magnetization of a 1-microgram sample of an organic superconductor, kappa-[bis(ethylenedithio)tetrathiafulvalene]2Cu(NCS)2, have been observed with this device.  相似文献