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The purpose of this paper is to provide empirical evidence on the neighboring effects of Internet adoption as measured by the percentage of firms with their own website in the European regions. This is the first study that explicitly analyzes the role played by spatial effects to explain website adoption for the European case. A set of instruments and techniques commonly used in the spatial econometrics framework is employed to test the hypothesis that proximity matters when explaining Internet adoption by firms. Results show that firms in physically adjacent regions register a similar degree of Internet adoption, confirming the presence in this context of positive spatial dependence. Nevertheless, the spatial effects detected are mainly constrained by national borders. Gross domestic product (GDP) per capita, population density, sectoral composition, and education are positively related to geographic distribution of Internet adoption in the enlarged European Union. In addition, regional disparities in Internet adoption were found to be less important than territorial inequalities in GDP per capita.  相似文献   
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Objective— To evaluate the fatigue life of partially stacked and fully stacked (1.5/2.0 and 2.0/2.7 mm) veterinary cuttable plates (VCP) in a fracture gap model of the distal aspect of the radius. Study Design— In vitro biomechanical study. Methods— Constructs (n=4/group) were assembled for each of 8 groups using 8‐hole plates (1.5/2.0 and 2.0/2.7 mm VCP) in the following configurations: unstacked; 2‐hole stacked centered over the gap (COG); 4‐hole stacked COG; and fully stacked. Plate(s) were secured to 2 separate polyvinylchloride pipe lengths, mounted to a mechanical testing system with a custom jig, and were loaded in axial compression for 106 cycles at 10 Hz or until failure at 6–60 N for the 1.5/2.0 mm VCP and 10–100 N for the 2.0/2.7 mm VCP. Differences in number of cycles, stiffness, and failure mode were recorded. Results— All construct failures occurred through a screw hole adjacent to the gap. Fully stacked and 4‐hole stacked 1.5/2.0 and 2.0/2.7 mm VCP withstood 106 cycles. Fatigue life and stiffness of the 1.5/2.0 or 2.0/2.7 mm unstacked constructs were significantly less than the other constructs. Differences were identified in stiffness among the 1.5/2.0 mm stacked constructs and in fatigue life among the 2.0/2.7 mm VCP stacked constructs. Conclusion— Four‐hole partially stacked VCP (either 1.5/2.0 or 2.0/2.7 mm) have comparable mechanical properties to fully stacked VCP. Clinical Relevance— Partial stacking of 2 holes of VCP on both sides of the fracture gap may provide sufficient strength for healing, but this premise must be tested in vivo.  相似文献   
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ABSTRACT The spatial distribution of manufacturing in the regions of the European Union over the period 1977–1999 is examined in this article, using a series of nonparametric instruments proposed within the framework of the economic growth literature. These enable us to overcome some of the methodological limitations of the studies of this issue that have appeared to date. The results obtained reveal an increase in geographic concentration in most industrial activities during the whole of the period considered, the relevance of which has been especially important coinciding with the progress made in the economic integration process currently underway in Europe. Indeed, the empirical evidence presented in this respect suggests that this trend will continue in the future. Additionally, the observed degree of intrasectoral mobility is relatively low. Nevertheless, these findings reveal that the probability of further growth or decline in a given sector within a particular region is greater in those areas with an intermediate presence of the sector in question.  相似文献   
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We characterized the pattern of ultrasonographic contrast enhancement of the small intestinal wall using a commercial contrast medium (Sonovue®) in 10 healthy awake cats. Subjectively, a rapid intense enhancement of the serosal and submucosal layers was followed by gradual enhancement of the entire wall section during the early phase. At peak enhancement, there was a subjective loss of demarcation between intestinal wall layers. In the late phase, there was a gradual wash out of signal from the intestinal wall. Submucosal wash out occurred last. Time‐intensity curves were generated for selected regions in the intestinal wall and multiple perfusion parameters were calculated for each cat. Perfusion parameters included arrival time (7.64 ± 2.23 s), baseline intensity (1.04 ± 0.04 a.u.), time to peak from injection (10.74 ± 2.08 s), time to peak from initial rise (3.1 ± 1.15), peak intensity (8.92 ± 3.72 a.u.), wash‐in rate (2.06 ± 0.70 a.u./s) and wash‐out rate (?1.07 ± 0.91 a.u./s). The perfusion pattern of normal feline small bowel may be useful for characterizing feline gastrointestinal disorders that involve the intestinal wall.  相似文献   
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Pulmonary hypertension has been associated with mitral insufficiency caused by chronic degenerative valve disease in dogs. Our aim was to search for associations between left atrial to aortic root ratio, end‐systolic and end‐diastolic volume indices, and changes in the right ventricular to right atrial pressure gradient as estimated by the peak velocity of tricuspid regurgitation in dogs with chronic degenerative valve disease and different classes of heart failure. Dogs, for which follow‐up was available were evaluated for changes in the right ventricular to right atrial systolic pressure gradient over time. Three hundred and forty‐four dogs were studied; 51 in the International Small Animal Cardiac Health Council class 1a, 75 in class 1b, 113 in class 2, 97 in class 3a, and 8 in class 3b. The mean values for right ventricular to right atrial systolic pressure gradient, end‐systolic volume index, end‐diastolic volume index, and left atrial to aortic ratio were 49.2 ± 17.1 mmHg, 149.12 ± 60.8 and 37.7 ± 21.6 ml/m2, and 1.9 ± 0.5, respectively. A weak positive correlation was found between the right ventricular to right atrial systolic pressure gradient and the left atrial to aorta ratio (r=0.242, P<0.0001), end‐diastolic volume index (r=0.242, P<0.0001), and end‐systolic volume index (r=0.129, P<0.001). Follow up was available for 49 dogs. Of these, 18 had an increased, 12 a decreased, and 19 a stable right ventricular to right atrial systolic pressure gradient despite therapy. The equivalence point between the sensitivity and specificity curves of about 80% in the coincident point corresponded to a right ventricular to right atrial systolic pressure gradient of 48 mmHg. Our results suggest an association between the progressive nature of chronic degenerative mitral valve disease and pulmonary hypertension. It is of clinical interest that, with a right ventricular to right atrial systolic pressure gradient pressure gradient at or above 48 mmHg, pulmonary hypertension does not appear to improve despite therapy targeted at lowering the left atrial load.  相似文献   
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The springtime spatial pattern of demersal fish assemblages in the northern Argentine coastal ecosystem (34°–41°S) and their relationships with environmental variables were investigated over 6 years (1981, 1983, 1994, 1995, 1998 and 1999). For each fish assemblage area for each year, we identified the most common species and those species that had the highest ability to discriminate it from adjacent assemblage areas. Within each area, species were considered as resident (common in all years) or facultative (contributing to less than 90% of similarity within any year). The analysis (detrended canonical correspondence analysis), conducted using species abundances (t nm?2) and environmental data, indicated that six fish assemblage areas are consistently distinguishable. The fish assemblage areas correspond to inner, central and middle regions of the Río de la Plata estuary, and inner, central and middle regions of the coastal shelf. Spatial differences in the composition among areas were primarily due to changes in species composition rather than changes in relative abundance, and were primarily related to water mass characteristics. Salinity in the estuary and temperature on the shelf were more relevant to the spatial structuring of the fish community in each environment. The assemblage areas showed a remarkable degree of temporal persistence in species composition and geographical location. The facultative species contributed more to the species composition temporal dynamics than resident species. El Niño (La Niña) condition, associated with increase (decrease) of the Río de la Plata freshwater discharge, produced a movement of the estuarine assemblage areas to the coastal shelf (upriver). Under normal freshwater discharge conditions, the boundaries of the fish assemblages were relatively more stable.  相似文献   
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