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This study was aimed to provide anatomical atlas of the ovine metacarpo/metatarsophalangeal joints using computed tomography (CT) scan and magnetic resonance imaging (MRI), as well as to investigate bone mineral density (BMD) and morphometric features of this joint. The limbs of twenty adult Sanjabi sheep were examined. Imaging was performed using a 16-slice multi-detector CT scanner and a 1.5 Tesla MRI scanner. The obtained images were correlated with corresponding anatomical sections. BMD was measured by Dual Energy X-ray Absorptiometry (DEXA) method. Also morphometric features included distance between metacarpal and metatarsal heads, width of metacarpal and metatarsal head, length, width and the height of the proximal sesamoid bones were measured. In MRI images, compact bones, ligaments and tendons showed less signal intensity (hypointense). The fatty tissue and bone marrow had more signal intensity (hyperintense), but articular cartilage and synovial fluid showed moderate signal intensity. BMD in the left hind limb was significantly higher than other three limbs (p ≤ 0.05). The length of proximal sesamoid bones in left forelimb was higher than right forelimb (p ≤ 0.05). The thickness of proximal sesamoid bones in left limbs was higher than those in their counterparts (p ≤ 0.05). The width of the medial head in the forelimbs was significantly greater than the hind limbs (p ≤ 0.05). The present results might be useful in managing the clinical techniques on this joint. Larger volume of the proximal sesamoid bones and wider medial head in the forelimbs compared to the hindlimbs impel this speculation that the centre of gravity is closer to the forelimbs. 相似文献
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Fariba Ghaderi Bahram Sharifnabi Mohammad Javan-Nikkhah Patrick C. Brunner Bruce A. McDonald 《Plant pathology》2020,69(8):1482-1491
The centre of origin of the globally distributed wheat pathogen Parastagonospora nodorum has remained uncertain because only a small number of isolates from the Fertile Crescent were included in earlier population genetic and phylogeographic studies. We isolated and genetically analysed 193 P. nodorum strains from three naturally infected wheat fields distributed across Iran using 11 neutral microsatellite loci. Compared to previous studies that included populations from North America, Europe, Africa, Australia, and China, the populations from Iran had the highest genetic diversity globally and also exhibited greater population structure over smaller spatial scales, patterns typically associated with the centre of origin of a species. Genes encoding the necrotrophic effectors SnToxA, SnTox1, and SnTox3 were found at a high frequency in the Iranian population. By sequencing 96 randomly chosen Iranian strains, we detected new alleles for all three effector genes. Analysis of allele diversity showed that all three effector genes had higher diversity in Iran than in any population included in previous studies, with Iran acting as a hub for the effector diversity that was found in other global populations. Taken together, these findings support the hypothesis that P. nodorum originated either within or nearby the Fertile Crescent with a genome that already encoded all three necrotrophic effectors during its emergence as a pathogen on wheat. Our findings also suggest that P. nodorum was the original source of the ToxA genes discovered in the wheat pathogens Phaeosphaeria avenaria f. sp. tritici 1, Pyrenophora tritici-repentis, and Bipolaris sorokiniana. 相似文献
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Jamali A Roostaee MH Soleimanjahi H Ghaderi Pakdel F Bamdad T 《Comparative immunology, microbiology and infectious diseases》2007,30(2):71-80
The use of morphine has been demonstrated to increase susceptibility to infections. Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen among immunocompromised individuals. In the present study, due to the importance of HSV vaccination in morphine abusers, the effects of chronic morphine exposure on the host response to a HSV-1 gB DNA-based vaccine have been investigated. The study is addressing an important aspect of vaccine development among the susceptible (immunocompromised) hosts. BALB/c mice were exposed to morphine over 11 days. They were then vaccinated with DNA vaccine or KOS strain as a live vaccine. The findings showed that the morphine-treated animals failed to respond to DNA vaccination evaluated by the anti-HSV gB antibody titer, delayed type hypersensitivity (DTH) and lethal HSV-1 challenge. Under the same conditions, the KOS vaccine showed a reduced Ab titer and DTH response in morphine-treated mice, but could protect mice against the lethal challenge and was safe for vaccination of morphine-treated animals. 相似文献
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S. H. R. Sadeghi B. Ghaderi Vangah N. A. Safaeeian 《Land Degradation \u0026amp; Development》2007,18(6):608-620
The effects of grazing and cultivation management on infiltration, runoff and sediment yield on storm basis were quantified for summer rangeland in the Matash mountains (Talesh Region), northern Iran. The infiltration experiments were made using double cylinder infiltrometer with five replicates within each study treatment. The runoff generation and sediment yield were measured using standard plots (1·83 m × 22·18 m) in three replications. The peak and the terminal instantaneous infiltration, and runoff and sediment rates were compared using independent and paired sample t‐test in two aforesaid treatments, respectively. The terminal and the peak instantaneous infiltration rates of 39·6 and 342·9 mm/h showed a respective significant increase (p < 0·001) of 32 and 39 per cent in cultivated areas compared to those in open grazing treatments. The results of runoff analysis also showed that there was a significant difference (p < 0·001) in runoff generation in two above‐mentioned areas. The runoff water was also found to be 5·63‐folds more in case of open grazing treatment in comparison with that generated by cultivated plots. A significant difference (p < 0·001) in sediment yield between two study treatments was also proved by the results obtained through sediment yield study. The soil loss in open grazing treatment was found to be 26·6 times more than of that occurred in cultivated plots. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
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The purpose of this research was to identify the pathogens causing root and crown rot in major pomegranate-growing areas of Iran. Infected tissue samples were collected from trees with symptoms from 49 pomegranate orchards in four provinces of Iran: Fars, Markazi, Isfahan, and Kohgiluyeh va Boyer-Ahmad. In total, 23 Phytophthora spp. isolates were obtained, which were identified as P. cryptogea species complex (12 isolates) and P. cinnamomi (11 isolates) based on morphological characters. Molecular confirmation of identification was performed by inference of phylogeny of ITS-rDNA regions, β-tubulin gene, and the mitochondrial gene cytochrome c oxidase subunit 1. The results of our phylogenetic analysis confirmed the morphological identification of P. cinnamomi isolates and placed them in Clade 7c of Phytophthora. In addition, the P. cryptogea species complex isolates, despite morphological similarities, were in fact four distinct species including P. cryptogea sensu stricto (two isolates), P. pseudocryptogea (one isolate), P. sp. kelmania (one isolate), and P. erythroseptica (six isolates). This is the first report of pomegranate root and crown rot caused by P. cinnamomi and P. cryptogea species complex. 相似文献
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This experiment was conducted to evaluate the effects of three nutrient recipes containing different concentrations of macronutrients in the vegetative stage [Vegetative Nutrient Solution: (VNS-I, VNS-II, and VNS-III)] and two nutrient recipes in reproductive stage [Reproductive Nutrient Solution: (RNS-I and RNS-II)], on physiological and biochemical parameters of strawberry ‘Paros’ in a soilless system. The results indicated the significant effects of nutrient solution on the photosynthetic capacity, yield, minerals uptake and titratable acidity of strawberry fruits. In the other hand fruit total soluble solids affected by vegetative nutrient solution. The highest yield was obtained under application of lowest level of minerals. Vegetative growth including leaf number and leaf area, as well as total chlorophyll were the highest as potassium (K+), calcium (Ca2+), and nitrogen (N) concentrations were increased. The highest content of N and Ca2+ uptake were in VNS-III × RNS-I formulation. Additionally, the highest vitamin C was in VNS-I formulation. Moreover, the most firmed fruits and the highest post-harvest shelf life of fruits were produced in VNS-III × RNS-I formulation. 相似文献
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Summary Parents and F2 progenies of an 8×8 diallel cross were grown under non-compacted and compacted soil conditions. Soil compaction reduced yield, pods per plant, and seeds per pod; however, an increase in seed wieght and no effect for pod length were observed. With the exception of pods per plant, the remaining traits had larger genetic variances under non-compacted soil conditions. Phenotypic correlations involving yield and related traits were similar under the two conditions. Tolerance to soil compaction and mean performance over the two soil conditions were defined. Genetic correlations in terms of: (1) the ratio of genetic variances under the stress and non-stress conditions, and (2) the correlation between performance under the two conditions, were calculated and discussed.Journal Article No. 10900 of the Michigan Agricultural Experiment Station. 相似文献
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Rainak Ghaderi Keyvan Tadayon Sargis Avagyan Pejvak Khaki Soheila Moradi Bidhendi Ken James Forbes Nader Mosavari Mohammad Reza Toroghi Farhad Moosakhani Reza Banihashemi Mohamad Sekhavati Nasim Karimnasab 《Tropical animal health and production》2013,45(4):889-894
Salmonella enterica Enteritidis is the most frequent etiological agent of salmonellosis in humans and poultry. To understand the genetic diversity of S. Enteritidis in Iran, we examined 69 chicken isolates from 18 broiler farms and six non-epidemic human isolates from six geographically distant provinces by multi-locus variable-number tandem repeat analysis (MLVA). Among SE2, SE3, SE5, SE7, SE8, SENTR4, and SENTR7, only SE5 with four and SENTR7 with two alleles, respectively, proved variable giving estimates of locus genetic diversity of 0.58 and 0. In all, six closely related MLVA profiles were identified among which three were commonly represented by human and chicken isolates. This population homogeneity contrasts with the high diversity at these loci reported elsewhere and is likely a consequence of a single clone of S. Enteritidis distributed across Iran. 相似文献
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Mehdi Ghahartars Shabnam Abtahi Zahra Zeinali Mohammad Javad Fattahi Abbas Ghaderi 《Iranian Biomedical Journal》2021,25(2):88
Background:TNF-α and IL-6 are both pleiotropic cytokines playing major roles in cancer-associated cytokine networks. They have previously been investigated for their function in skin malignancies, mostly melanomas, and studies on NMSC patients are relatively rare. In this study, we aimed to assess the associations of serum levels of IL-6 and TNF-α with NMSCs and its clinicopathological features. Methods:This cases-control study was carried out to investigate the serum levels of TNF-α and IL-6 in 70 NMSC patients, in comparison with 30 healthy individuals, by means of flow cytometric bead-based immuneoassay. Results:Serum levels of both TNF-α and IL-6 were significantly higher in NMSC patients (6.470 vs. 4.355 pg/ml; p = 0.0468, respectively), compared to healthy individuals (3.205 vs. 0.000 pg/ml; p = 0.0126, respectively). In the subgroup analysis, SCC patients had higher serum levels of IL-6 compared to healthy individuals (3.445 vs. 0.000 pg/ml; p = 0.0432). No other significant differences were observed in the serum levels of these two cytokines among different clinicopathological subgroups of the patients. Conclusion:The increased levels of TNF-α and IL-6 in NMSC patients can be introduced as an epiphenomenon of a complex cancer-induced cytokine cascade. Key Words: Biomarkers, Cytokines, Interleukin-6, Tumor Necrosis Factor-alpha 相似文献
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Sima Balouchi-Anaraki Simin Ahmadvand Akbar Safaei Abbas Ghaderi 《Iranian Biomedical Journal》2021,25(5):310
Background:PACC is a rare type of pancreatic exocrine neoplasm that is frequently diagnosed at late stages with a high rate of metastasis. Identification of new biomarkers for PACC can improve our knowledge of its biology, early detection, or targeted therapy. In this study, hybridoma technology was used to generate mAbs against Faraz-ICR, a pancreatic acinar cell carcinoma cell line. Methods: Cell ELISA and flow cytometry were used for screening, and the 4H12 hybridoma clone was selected for further analysis. The 4H12 mAb was specific for MYH9 as determined by Immunoprecipitation, Western blot, and mass spectrometry. Results:This antibody reacted variably with other cancer cells, in comparison to Faraz-ICR cell. Besides, by immunohistochemical staining, the acinar cell tumor, which was the source of Faraz-ICR, showed high MYH9 expression. Among 21 PDAC cases, nine (42.8%) expressed MYH9 with low intensity, while 10 (47.8%) and 2 (9.5%) cases expressed MYH9 with moderate to strong intensities, respectively. The 4H12 mAb inhibited the proliferation of Faraz-ICR cells in a dose-dependent manner from 0.75 to 12.5 μg/ml concentrations (p < 0.0001 and p < 0.002). IC50 values were achieved at 12.09 ± 4.19 µg/ml and 7.74 ± 4.28 µg/ml after 24- and 48-h treatment, respectively. Conclusion:Our data suggest that the 4H12 mAb can serve as a tool for investigating the role of MYH9 pancreatic cancer biology and prognosis. Key Words: Acinar cell carcinoma, Biomarkers, Monoclonal antibody, Pancreas 相似文献
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