An evaluation of an oral formulation of moxidectin against selected anthelmintic-resistant and -susceptible strains of nematodes in lambs     

Bisset SA  Vlassoff A  McMurtry LW  Elliott DC  Cobb RM  Kieran PJ  Wood IB 《New Zealand veterinary journal》1992,40(3):97-100

The efficacy of an oral formulation of the newly developed parasiticide, moxidectin, was tested against benzimidazole-resistant Haemonchus contortus, Trichostrongylus colubriformis, and Nematodirus spathiger, levamisole-resistant Ostertagia circumcincta, and susceptible Cooperia curticei infections in weaned lambs. Thirty-two lambs were experimentally infected with mixed doses of the above strains of nematodes. They were allocated into four treatment groups by stratified randomisation using liveweights and faecal egg counts 28 days later. One group received moxidectin at 0.2 mg/kg liveweight, one group oxfendazole at 4.5 mg/kg liveweight, one group levamisole at 7.5 mg/kg liveweight and the last group remained untreated as the control. Worm burdens in the lambs at slaughter 10 days after oral treatment confirmed the resistance status of the nematode strains used, and showed that moxidectin had a greater than 99.9% efficacy (p<0.01) against all of them. No adverse effects due to treatment with moxidectin were observed in any of the animals.  相似文献   

Public involvement in scientific decision-making     

Cobb JC 《Science (New York, N.Y.)》1976,194(4266):674

  相似文献   

Intestinal immunomodulation by vitamin A deficiency and lactobacillus-based probiotic in Eimeria acervulina-infected broiler chickens     

Dalloul RA  Lillehoj HS  Shellem TA  Doerr JA 《Avian diseases》2003,47(4):1313-1320

In a 2 X 2 factorial study, a broiler starter ration was amended for vitamin A (control, C; deficient, A) and probiotic status (-, P) to investigate their modulatory effects onthe host immune system. Birds were inoculated orally with Eimeria acervulina (EA) oocysts, and disease susceptibility was evaluated by assessment of fecal oocyst shedding. Humoral and local cellular mediated immunity were assessed by evaluation of antibody and cytokine (interferon-gamma [IFN-gamma] and interleukin-2 [IL-2]) levels in sera and intestinal secretions on a 3-day interval after inoculation. Fecal oocyst shedding was highest (P < 0.05) in A- birds, followed by AP, C-, and CP birds. Feeding the probiotic reduced shed oocysts by 20% in A fed birds and by 26% in C fed birds. Intestinal IFN-gamma was relatively constant in all treatment groups except for A-, where it declined steadily and was lower (P < 0.05) from day 6 on. Serum IFN-gamma levels fluctuated within each treatment and over time were not revealing. Intestinal IL-2 was highest in CP birds at 3 and 9 days postinfection (DPI) and lowest in A- birds at 3, 9, and 12 DPI (P < 0.05); no difference between treatments was found at 6 DPI (P > 0.05). Eimeria-specific intestinal antibody (Ab) level was constant (P > 0.05) in C- birds but increased with time (P < 0.05) in A-, AP, and CP birds. Serum Ab levels were also constant in A- and CP birds but increased (P < 0.05) in C- and AP birds after 6 DPI. The data demonstrate for the first time a probiotic-enhanced immunity in vitamin A deficient birds. This study is also the first to demonstrate the probiotic effect on local cell-mediated immunity of chickens, best manifested by apparent lower intestinal invasion and development by EA, on the basis of higher IL-2 secretion and lower EA oocyst production.  相似文献   

Emamectin,a novel insecticide for controlling field crop pests     

Ishaaya I  Kontsedalov S  Horowitz AR 《Pest management science》2002,58(11):1091-1095

Emamectin is a macrocyclic lactone insecticide with low toxicity to non-target organisms and the environment, and is considered an important component in pest-management programmes for controlling field crop pests. It is a powerful compound for controlling the cotton bollworm Helicoverpa armigera (Hübner). A spray concentration of 25 mg AI litre-1 in a cotton field resulted in over 90% suppression of H armigera larvae up to day 28 after treatment, while similar mortality of the Egyptian cotton leafworm Spodoptera littoralis Boisduval, under the same conditions, was maintained for 3 days only. Emamectin is a potent compound for controlling the western flower thrips Frankliniella occidentalis (Pergande) under both laboratory and field conditions and its activity on adults was over 10-fold greater than that of abamectin. Spray concentrations of 10 and 50 mg AI litre-1 in Ageratum houstonianum Mill flowers resulted in total suppression of adults up to day 11 and of larvae up to day 20 after treatment. Under standard laboratory conditions, emamectin exhibits a considerable activity on the whitefly Bemisia tabaci (Gennadius) and the leafminer Liriomyza huidobrensis (Blanchard). Further studies are required to evaluate its potential activity on the latter pests under field conditions.  相似文献   

A cranial neuropathy associated with multicentric lymphosarcoma in a dog     

S L Hobbs  M A Cobb 《The Veterinary record》1990,127(21):525-526

  相似文献   

ON THE SIGNIFICANCE OF AN EXPERIMENTAL DIFFERENCE,WITH A PROBABILITY TABLE FOR LARGE DEVIATIONS     

Cobb PW 《Science (New York, N.Y.)》1921,54(1392):200-202

  相似文献   

Use of a programmable, activity-sensing, rate-regulating Sacemaker in dog     

M. A. Cobb  J. Nolan  S. E. Brownlie  R. H. Abercromby  A. L. Fussell 《The Journal of small animal practice》1990,31(8):398-400

A multi-programmable, single chamber pulse generator with automatic, activity-sensing rate regulation was successfully implanted into an eight-year-old crossbred dog with symptomatic third-degree atrioventricular heart block. Postoperative Holter monitoring confirmed appropriate activity-related changes in the ventricular rate.  相似文献   

SEGMENTATION IN NEMATODES: OBSERVATIONS BEARING ON THE UNSETTLED QUESTION OF THE RELATIONSHIP OF NEMATODES TO OTHER BRANCHES OF THE ANIMAL KINGDOM     

Cobb NA 《Science (New York, N.Y.)》1917,45(1171):593

  相似文献   

RFLP mapping of QTLs for photoperiod response in tropical sorghum     

J. Chantereau  G. Trouche  J.F. Rami  M. Deu  C. Barro  L. Grivet 《Euphytica》2001,120(2):183-194

Genetic control of flowering time in sorghum was investigated using a recombinant inbred lines population derived from a cross between IS 2807, a slightly photoperiod sensitive tropical caudatum landrace, and IS 7680,a highly photoperiod sensitive tropical guinea landrace. Progenies were sown with their parents at six different dates between 1995 and 1997 in Burkina Faso. Direct field measures and synthetic measures derived from the implementation of a model were used to characterize the photoperiod response. Emphasis was put to identify the most relevant traits to account for Basic Vegetative Phase (BVP) and photoperiod sensitivity sensus stricto. One QTL was detected on Linkage Group (LG) F for the traits related to BVP. Two QTLs were detected on LGs C and H for the traits related to the photoperiod sensitivity sensus stricto. This gives credit to at least partially independent genetic determinisms for those two components of photoperiod response. Evidences for possible orthology of the QTLs detected here with other QTLs and major genes involved in flowering time of sorghum and rice are discussed. This revised version was published online in July 2006 with corrections to the Cover Date.  相似文献   

Effect of ice storage upon the free amino acid contents of tails of white shrimp (Penaeus setiferus)     

B F Cobb  C Vanderzant  K Hyder 《Journal of agricultural and food chemistry》1974,22(6):1052-1055

  相似文献