Molecular epidemiology of feline bordetellosis in two animal shelters in California,USA     

Foley JE  Rand C  Bannasch MJ  Norris CR  Milan J 《Preventive veterinary medicine》2002,54(2):141-156

"Kennel cough" in dogs in animal shelters is readily transmissible, reduces adoption rates, and commonly leads to the euthanasia of affected dogs. In cats, tracheobronchitis, conjunctivitis, and pneumonia have been associated with Bordetella bronchiseptica infection-but most cases of upper-respiratory infection (URI) probably are caused by herpesvirus and calicivirus, and many B. bronchiseptica culture-positive cats are clinically normal. Our prospective observational study was undertaken to document the contribution of B. bronchiseptica to disease in cats and dogs from two animal shelters undergoing outbreaks of canine kennel cough, to evaluate whether cross-species transmission might have occurred, and to determine if the presence of infected cats represented a risk to dogs. Clinically defined cases of kennel cough in dogs and URI in cats were investigated in two shelters by calculating clinical-disease incidence, alveolar-lavage cytological examination, bacterial and viral cultures, antibiotic-susceptibility testing, and molecular fingerprinting by pulsed-field gel electrophoresis.In a 40-cat and 40-dog "no-kill" shelter, the prevalences of culture positivity were 47% for B. bronchiseptica and 36% for calicivirus at the same time as two resident dogs demonstrated clinical cough. When no dogs had kennel cough 3 months later, 10% of cats were B. bronchiseptica-culture-positive and 63% calicivirus positive. In a large traditional shelter, the incidence of kennel cough in dogs increased over 12 weeks to a maximum of 19 cases/week/120 dogs, during which time the culture prevalence was 23% for B. bronchiseptica in dogs and 47% in cats. Three to 6 months before the kennel-cough epidemic, no dogs or cats were B. bronchiseptica positive. Very little genetic variability was detected in isolates from these shelters; all isolates except one corresponded to a single strain type which was identical to the pattern in a vaccine used in these shelters. Isolates from other cats, a horse, a llama, and a sea otter were genetically distinct from the shelter isolates. There was widespread resistance to cephalosporins and ampicillin, but low or no resistance to amoxicillin/clavulanate, trimethoprim-sulfamethoxazole, tetracycline, and enrofloxacin. Greater percent resistance was observed in the traditional shelter than in the no-kill shelter and feline isolates were more likely to be resistant than canine isolates.  相似文献   

Concentrations of substance P and prostaglandin E2 in synovial fluid of normal and abnormal joints of horses     

Kirker-Head CA  Chandna VK  Agarwal RK  Morris EA  Tidwell A  O'Callaghan MW  Rand W  Kumar MS 《American journal of veterinary research》2000,61(6):714-718

OBJECTIVE: To correlate substance P content of synovial fluid with prostaglandin E2 content, radiographic evidence of joint abnormality, and anatomic location of the joint for normal and osteoarthritic joints of horses. SAMPLE POPULATION: Synovial fluid from 46 normal joints in 21 horses and 16 osteoarthritic joints in 10 horses. PROCEDURE: Normal and osteoarthritic joints were identified by clinical and radiographic examination, by response to nerve blocks, during scintigraphy or surgery, or by clinicopathologic evaluation. Substance P and prostaglandin E2 contents of synovial fluid were determined by radioimmunoassay. Radio-graphs of joints were assigned a numeric score reflecting severity of lesions. Joints were assigned a numeric score reflecting anatomic location. RESULTS: Median concentrations of substance P and prostaglandin E2 were significantly increased in osteoarthritic joints, compared with normal joints. A significant correlation was found between concentrations of substance P and prostaglandin E2 in synovial fluid, but a correlation was not detected between substance P concentration in synovial fluid and anatomic location of the joint or between radiographic scores of osteoarthritic joints and concentrations of substance P or prostaglandin E2. CONCLUSIONS AND CLINICAL RELEVANCE: A correlation existed between concentrations of substance P and prostaglandin E2 in synovial fluid obtained from normal and osteoarthritic joints. However, content of substance P in synovial fluid cannot be predicted by the radiographic appearance of the joint or its anatomic location. Substance P and prostaglandin E2 may share an important and related role in the etiopathogenesis of osteoarthritis, lending credence to the importance of neurogenic inflammation in horses.  相似文献   

Prognostic significance of serum alkaline phosphatase activity in canine appendicular osteosarcoma   总被引：3，自引：0，他引：3  

Garzotto CK  Berg J  Hoffmann WE  Rand WM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2000,14(6):587-592

Sixty-one dogs with appendicular osteosarcoma were treated with amputation and chemotherapy of cisplatin and doxorubicin. Serum samples were obtained before and after treatment for determination of total alkaline phosphatase (TALP) activity as well as the activities of the constituent bone (BALP), liver (LALP), and corticosteroid-induced (CALP) isoenzymes. The relationship between alkaline phosphatase activities and survival was examined by Cox proportional hazards regression analysis and Kaplan-Meier log rank analysis. Mean activity of TALP, BALP, and LALP decreased significantly after treatment (P < .001). TALP and LALP activities before treatment were significantly correlated with survival (P = .006 and .001, respectively). The correlation between BALP activity before treatment and survival approached significance (P = .054). CALP activity and TALP, BALP, and LALP activities after treatment were not significantly correlated with survival. Dogs with normal pretreatment TALP and BALP activities survived significantly longer than dogs with increased pretreatment activities (P = .001 and .003, respectively). Median survival times for dogs with normal or increased TALP activities before treatment were 12.5 and 5.5 months, respectively; and median survival times for dogs with normal or increased BALP activities before treatment were 16.6 and 9.5 months, respectively. In the design of future clinical trials involving dogs with osteosarcoma, consideration should be given to stratifying the randomization according to alkaline phosphatase activity. In addition, alkaline phosphatase activity should be a factor considered by clinicians attempting to tailor the aggressiveness of adjuvant chemotherapy to the needs of individual patients or owners.  相似文献   

A Combination Chemotherapy Protocol (VELCAP-L) for Dogs with Lymphoma   总被引：3，自引：1，他引：2  

Barbara I. Zemann  Antony S. Moore  William M. Rand  Gail Mason  David M. Ruslander  Angela E. Frimberger  Carrie A. Wood  Deborah A. L'Heureux  John Gliatto  Susan M. Cotter 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1998,12(6):465-470

Ninety-eight dogs with lymphoma treated with a 5-drug combination chemotherapy regimen (vincristine, L-asparaginase. cyclophosphamide, doxorubicin, prednisone [VELCAP-L]) were evaluated for pretreatment characteristics predictive for response and remission duration. The complete remission rate was 69%, with a median remission duration of 55 weeks. Dogs with advanced stage of disease, constitutional signs, dogs that were older, and dogs that were dyspneic were less likely to achieve remission. Once in remission, small dogs and dogs without pretreatment thrombocytopenia were likely to have longer remission duration. Toxicoses were frequent, but rarely fatal, and no predictitive factors were found for a dog developing toxicoses. VELCAP-L is an effective treatment for dogs in stage I-III lymphoma, particularly in young, small animals.  相似文献   

The effect of heavy metals and other pollutants on the sediments of Onondaga Lake     

S. W. Effler  M. C. Rand  T. A. Tamayo 《Water, air, and soil pollution》1979,12(2):117-134

Physical and chemical characterization of the recent sediments of Onondaga Lake indicate significant pollution based alterations to the system.²¹⁰Pb data depict an extremely high sedimentation rate within the consolidated layers (5 to 9 cm yr^?1), that has resulted largely from the loading of the Lake with industrially derived Ca. A further alteration of the sedimentary system is the very extensive flocculent layer (up to 2.5 m deep) between the overlaying water and the consolidated sediments. The chemistry of the sediments, though not unusual in dominant component makeup for a hardwater lake, is characterized by very severe heavy metal and Fe contamination that has resulted from culturally derived loadings. Heavy metals and P are concentrated within the upper flocculent strata. Indirect evidence is presented for the upward vertical migration of heavy metals within the sedimentary system.  相似文献   

Pre-drift continental nuclei   总被引：3，自引：0，他引：3  

Hurley PM  Rand JR 《Science (New York, N.Y.)》1969,164(3885):1229-1242

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Entrainment of the body temperature rhythm in rats: effect of color and intensity of environmental light   总被引：2，自引：0，他引：2  

R A McGuire  W M Rand  R J Wurtman 《Science (New York, N.Y.)》1973,181(103):956-957

The daily rhythm in body temperature in rats was continuously monitored during exposure to low-intensity environmental illumination of various colors in the visible and near-ultraviolet spectrum. The ability of phase shifts in the lighting schedule to induce concomitant changes in the rhythm was used to determine the spectral sensitivity of the retinal photoreceptor systems mediating rhythm entrainment. Green light (lambda = 530 +/- 45 nanometers) was most potent, and red (lambda = 660 +/- 19 nanometers) and ultraviolet (lambda = 360 +/- 34 nanometers) were least potent in entraining the temperature rhythm.  相似文献   

Test of Continental Drift by Comparison of Radiometric Ages: A pre-drift reconstruction shows matching geologic age provinces in West Africa and Northern Brazil     

Hurley PM  Rand JR  Pinson WH  Fairbairn HW  de Almeida FF  Melcher GC  Cordani UG  Kawashita K  Vandoros P 《Science (New York, N.Y.)》1967,157(3788):495-500

1) The distribution of age values obtained by potassium-argon determinations and whole-rock rubidium-strontium determinations appears to be almost identical for West African rocks of the pervasive Eburnean Orogenic Cycle and basement rocks at opposite locations in South America. 2) There is also a close correlation, with respect to potassium-argon age determinations on micas, rubidium-strontium determinations on total-rock samples, and the extent to which these two sets of values differ, between rocks of the Pan-African Orogenic Cycle and rocks of the Caririan Orogenic Cycle in Brazil, where these two groups of rocks lie opposite each other in the two continents. 3) When Africa and South America are "fitted together," the sharply defined boundary between the Eburnean and the Pan-African age provinces in West Africa strikes directly toward the corresponding age boundary in northeast Brazil. 4) The transition from the 550-million-year Pan-African age province to the 2000-million-year age province in the Congo Craton in Cameroun-Gabon is matched in the rocks near the corresponding part of the east coast of Brazil. However the geological and age data are insufficient to do more than suggest the possibility of another age-boundary correlation here. 5) The evidence reported here supports the hypothesis of continental drift.  相似文献   

Plasma Corticosteroids: Changes in Concentration after Stimulation of Hippocampus and Amygdala     

Mandell AJ  Chapman LF  Rand RW  Walter RD 《Science (New York, N.Y.)》1963,139(3560):1212

Plasma 17-OH corticosteroid levels were determined before stimulation and at various intervals after stimulation in these limbic sites in patients in whom implanted electrodes had been placed during evaluation for surgical treatment of psychomotor epilepsy. Stimulation of the amygdala was followed by an elevation of plasma 17-hydroxycorticosteroids. Hippocampal stimulation resulted in a decreased corticosteroid level, followed in two instances by a secondary elevation.  相似文献   

SECTION F--ZOOLOGICAL SCIENCES AND ASSOCIATED SOCIETIES     

Rand HW 《Science (New York, N.Y.)》1922,55(1430):572-573

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