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Distribution of oxytetracycline to tissue cages and granuloma pouches in calves and effect of acute inflammation on distribution to tissue cages 总被引：1，自引：0，他引：1
B. BENGTSSON J. LUTHMAN S. O. JACOBSSON S. EKMAN 《Journal of veterinary pharmacology and therapeutics》1991,14(4):385-394
The effect of acute inflammation on oxytetracycline (OTC) distribution was studied in a tissue cage model in calves. An acute inflammatory reaction was induced in tissue cages by injecting lipopolysaccharide (LPS) from Salmonella typhimurium. The distribution of OTC to tissue cage fluid (TCF) was also compared with distribution to fluid from granuloma pouches (GPF). Tissue from LPS-injected cages showed histological changes indicating an acute inflammatory reaction. Concentrations of OTC were higher in LPS cages than in controls; at 1, 2, 4 and 10 h the difference was statistically significant (P less than 0.05). Numerically the overall elimination rate constant (kel) was larger, elimination half-life (t1/2) shorter, peak concentration (Cmax) higher, and time of peak concentration (Tmax) shorter in LPS cages than in controls. The area under the curve (AUC) of OTC was greater and the ratio AUCTCF/AUCserum was higher in LPS cages than in controls. Although statistically significant differences were not found for all the pharmacokinetic parameters, it was concluded that distribution to and elimination from LPS cages were both faster than in controls. Concentration-time profiles of OTC were similar in TCF and GPF in that concentrations were lower and elimination was more prolonged than in serum. Levels were higher in GPF than in TCF up to 3 h after injection; thereafter the relationship was reversed. Distribution to and elimination processes from GPF appeared to be faster than from TCF as numerically kel was higher, t1/2 shorter and Tmax shorter in GPF than in TCF. It was concluded that the granuloma pouch model and the tissue cage model have similarities in distribution and elimination patterns and that differences are most probably due to differences in the ratio of the surface area to the volume. 相似文献
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FREDRIK E. HOPPE DVM PHD DAVE A. HAGER DVM PAUL W. POULOS JR. DVM PHD STINA EKMAN DVM P. G. LINDGREN MD PHD 《Veterinary radiology & ultrasound》1986,27(4):99-101
A manual, ultrasound-guided biopsy technique was compared to a new automatic method using a new biopsy device. The liver and the left kidney of 10 dogs were biopsied using the two methods. The specimens from the biopsies were compared for size and quality. Results demonstrate that larger and higher quality samples were obtained with the new automatic method. 相似文献
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LARS EKMAN KERSTIN ORSTADIUS CARL BERTIL THORELL 《The Journal of small animal practice》1968,9(5):225-230
Abstract— Erythrocyte uptake in vitro of 131I-labelled triiodothyronine (EU test) was studied in dogs. A simultaneous estimation of blood cholesterol was made. The results indicate that hypothyreotic dogs can be detected by determination of EU and possibly of cholesterol. Dogs exhibiting alopecia and/or adiposity were shown to have significant lower EU and higher cholesterol values than clinical healthy dogs and those affected by acanthosis nigricans or dermatosis caused by infections or parasites. Résumé— L'auteur a étudié, chez le chien, l'absorption in vitro par les erythrocytes de la tri-iodothyronine I131 (test AE), cet examen étant accompagné du calcul estimatif du cholestérol sanguin. Les résultats obtenus portent à conclure que la détermination de 1'AE et, éventuellement, du cholestérol permet de déceler l'hypothyroïdie chez le chien. II a été constaté que chez les chiens atteints d'alopécie et/ou d'adiposité, les valeurs AE sont sensiblement plus faibles et les valeurs de cholestérol plus élevées que chez les sujets cliniquement normaux et chez ceux qui sont atteints soit d'acanthosis nigricans, soit de dermatoses dues aux infections ou aux parasites. Zusammenfassung— Erytrocytupptag in vitro av 131I-märkt trijodtyronin (EU-test) under-söktes samtidigt med blodkolesterolbestämning på hundar. Resultaten tyder på att hypothyros hos hund kan upptäckas genom denna bestämning av EU, eventuellt kombinerad medkolesterolbestämning. Hundar med alopcia och/eller adipositas visade sig ha signifikant lägre EU och högre kolesterolhalt än kliniskt friska djur och sadana som hade acanthosis nigricans eller dermatoser av infektiöst eller parasitärt ursprung. 相似文献
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K. OLSTAD B. YTREHUS S. EKMAN C. S. CARLSON N. I. DOLVIK 《Equine veterinary journal》2009,41(9):865-871
Reasons for performing study: It is presently unknown whether cartilage ischaemia plays any part in the pathogenesis of osteochondral fragmentation within the equine metatarsophalangeal joint, as no detailed studies on microcirculation in the area have been reported. Objective: To describe the developmental pattern of the blood supply to the epiphyseal growth cartilage in the metatarso‐phalangeal joint of foals. Methods: Eight Standardbred foals were sacrificed between birth and age 7 weeks to undergo a barium perfusion procedure to demonstrate vessels within growth cartilage canals of one hindlimb. The metatarso‐phalangeal joint was cleared in methyl salicylate and perfused vessels studied in the intact bones. The bones were sawed into 5 mm thick slabs, decalcified and radiographed. Selected slabs were cleared in methyl salicylate for a second time and examined at low magnification. The dorsal half of the sagittal ridge of the distal third metatarsal bone and the plantar half of the proximal phalanx were examined histologically. Results: Regions of the epiphysis with thick cartilage contained a greater number of perfused vessels than regions with thin cartilage. The cartilage canal vessels were oriented either parallel or perpendicular to the underlying ossification front. Cartilage canal vessels were incorporated into the ossification front during growth and became reliant on a subchondral arterial source. Macroscopically visible lesions were not detected in the current group of foals. On histological examination, pathological changes consisting of an area of chondronecrosis surrounded by fibrovascular granulation tissue were found in sections from the lateral proximo‐plantar eminence of the proximal phalanx in the 7‐week‐old foal. Conclusion: The same anatomical feature (traversing the ossification front to enter cartilage canals) reported to render vessels vulnerable to failure in the tarsus was also present in the metatarso‐phalangeal joint of foals. Potential relevance: Osteochondrosis may occur by the same pathogenetic mechanism in the metatarso‐phalangeal joint as in the tarsus of foals. 相似文献
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