A low-threshold test ban is feasible     

Feiveson HA  Paine CE  VON Hippel F 《Science (New York, N.Y.)》1987,238(4826):455-459

At present, nuclear explosions are limited by treaty to underground testing with yields of no more than 150 kilotons, and recently there have been renewed calls for further test restrictions. As part of these discussions, the U.S. Congress is considering bills that would legislate new limits to testing,whereas the Reagan Administration opposes such constraints. The editors of Science have asked two groups of participants in the debate to present their arguments for or against new limits to testing. Feiveson, Paine, and von Hippel argue for a treaty of indefinite duration between the United States and the Soviet Union, which includes the following provisions: (i) a ban on all testing outside a desiqnated site having known seismic properties; (ii)verification by means of on-site inspection and in-country seismic monitoring; (iii) unlimited testing below 1 kiloton at the special site; and (iv) an average of one test per year with a yield of up to 15 kilotons for ensuring reliability of the nuclear stockpile. MiUer, Brown, and Nordyke argue that a lowering of the present 150-kiloton threshold would be undesirable, and that new test bans would divert attention from a comprehensive approach to negotiated reductions in the nuclear and conventional arsenals of the United States and the Soviet Union.  相似文献   

Chloramphenicol 3. Clinical pharmacology of systemic use in the horse     

SW PAGE 《Australian veterinary journal》1991,68(1):5-8

The use of chloramphenicol in the horse is now prohibited as horses are classified as food-producing animals. However, chloramphenicol has until recently been widely available for oral, intramuscular or intravenous administration. A critical appraisal of the published literature on the use of chloramphenicol in the horse clearly demonstrates that there are sound pharmacokinetic and microbiological reasons for concluding that chloramphenicol is not an appropriate antibiotic for systemic use. The short half-life of chloramphenicol in the horse, together with the broad range of minimum inhibitory concentrations of target pathogens, preclude the use of practical dosage regimens. It can be concluded that the withdrawal of chloramphenicol will have no adverse effects on chemotherapy in the horse.  相似文献   

Technical information     

Paine TO 《Science (New York, N.Y.)》1972,176(4033):353

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Trophic control of production in a rocky intertidal community     

Paine RT 《Science (New York, N.Y.)》2002,296(5568):736-739

In the low intertidal zone at Tatoosh Island, Washington, United States, minimal estimates of primary production can vary from 0 to an average of 86 kilograms of wet mass per square meter per year when the grazing assemblage is manipulated. Highly productive annual kelps (Laminariales) replace less productive perennial species when macroscopic grazers are reduced or absent, resulting in monodominant assemblages of Alaria marginata. Experiments were repeated in seven consecutive years. Increased species richness makes no significant additional contribution to annual production. Rather, a competitively superior species is favored when its enemies are reduced, suggesting that terrestrial perspectives on the role of biodiversity that are developed without considering consumers may not be general.  相似文献   

The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses     

Stuart W. Paine  Jane Bright  James P. Scarth  Pamela R. Hincks  Clive M. Pearce  Colette Hannan  Marc Machnik  Lynn Hillyer 《Journal of veterinary pharmacology and therapeutics》2020,43(2):162-170

In equine and racing practice, detomidine and butorphanol are commonly used in combination for their sedative properties. The aim of the study was to produce detection times to better inform European veterinary surgeons, so that both drugs can be used appropriately under regulatory rules. Three independent groups of 7, 8 and 6 horses, respectively, were given either a single intravenous administration of butorphanol (100 µg/kg), a single intravenous administration of detomidine (10 µg/kg) or a combination of both at 25 (butorphanol) and 10 (detomidine) µg/kg. Plasma and urine concentrations of butorphanol, detomidine and 3-hydroxydetomidine at predetermined time points were measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). The intravenous pharmacokinetics of butorphanol dosed individually compared with co-administration with detomidine had approximately a twofold larger clearance (646 ± 137 vs. 380 ± 86 ml hr⁻¹ kg⁻¹) but similar terminal half-life (5.21 ± 1.56 vs. 5.43 ± 0.44 hr). Pseudo-steady-state urine to plasma butorphanol concentration ratios were 730 and 560, respectively. The intravenous pharmacokinetics of detomidine dosed as a single administration compared with co-administration with butorphanol had similar clearance (3,278 ± 1,412 vs. 2,519 ± 630 ml hr⁻¹ kg⁻¹) but a slightly shorter terminal half-life (0.57 ± 0.06 vs. 0.70 ± 0.11 hr). Pseudo-steady-state urine to plasma detomidine concentration ratios are 4 and 8, respectively. The 3-hydroxy metabolite of detomidine was detected for at least 35 hr in urine from both the single and co-administrations. Detection times of 72 and 48 hr are recommended for the control of butorphanol and detomidine, respectively, in horseracing and equestrian competitions.  相似文献   

Susceptibility of African buffaloes and Asiatic water buffaloes to foot-and-mouth disease     

G D Paine 《Australian veterinary journal》1990,67(2):N24-N25

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Influence of ozone and nitrogen deposition on bark beetle activity under drought conditions   总被引：3，自引：0，他引：3  

Michele Eatough Jones  Timothy D. Paine  Mark E. Fenn  Mark A. Poth 《Forest Ecology and Management》2004,200(1-3):67-76

Four years of severe drought from 1999 through 2003 led to unprecedented bark beetle activity in ponderosa and Jeffrey pine in the San Bernardino and San Jacinto Mountains of southern California. Pines in the San Bernardino Mountains also were heavily impacted by ozone and nitrogenous pollutants originating from urban and agricultural areas in the Los Angeles basin. We studied bark beetle activity and bark beetle associated tree mortality in pines at two drought-impacted sites in the San Bernardino Mountains, one receiving high levels of atmospheric pollutants, and one with more moderate atmospheric input. We also investigated the effects of nitrogen addition treatments of 0, 50 and 150 kg N ha⁻¹ year⁻¹ at each site. Tree mortality and beetle activity were significantly higher at the high pollution site. Differences in beetle activity between sites were significantly associated with ozone injury to pines, while differences in tree mortality between sites were significantly associated with both ozone injury and fertilization level. Tree mortality was 9% higher and beetle activity 50% higher for unfertilized trees at the high pollution site compared to the low pollution site. Tree mortality increased 8% and beetle activity increased 20% under the highest rates of nitrogen additions at the low pollution site. The strong response in beetle activity to nitrogen additions at the low pollution site suggests that atmospheric nitrogen deposition increased tree susceptibility to beetle attack at the high deposition site. While drought conditions throughout the region were a major factor in decreased tree resistance, it appears that both ozone exposure and atmospheric nitrogen deposition further increased pine susceptibility to beetle attack.  相似文献   

Abnormal Pressures in Deep Wells of Southwestern Louisiana: High fluid pressures are associated with slump-type faults and shed light on processes of compaction     

Dickey PA  Shriram CR  Paine WR 《Science (New York, N.Y.)》1968,160(3828):609-615

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Effect of an immunomodulatory feed additive on markers of immunity in pasture‐fed dairy cows     

MC Playford  K Dawson  SE Playford  AN Smith  SW Page  K Collins  N Forsberg 《Australian veterinary journal》2014,92(12):479-481

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Traditions and reforms: the schooling of china     

Paine L 《Science (New York, N.Y.)》1986,232(4753):1011-1012

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